Zobrazeno 1 - 10
of 16 522
pro vyhledávání: '"p‐JNK"'
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-10 (2024)
Abstract Oxidative stress causes diverse neurological disorders. Parthanatos is a type of programmed cell death, characterised by strong activation of poly (ADP-ribose) (PAR) polymerase-1 (PARP-1), PAR polymer accumulation, and nuclear translocation
Externí odkaz:
https://doaj.org/article/b79a7022ddbd4a6cb08f9a4037247ba9
Autor:
Wei Xiong, Ya Xie, Dong Wang, Xiaozhi Huang, Xiaohui Hao, Jianming Liu, Xiaohui Liu, Xiaobin Gu, Shaoqian Sun, Yufeng Li, Jingwu Li
Publikováno v:
BMC Cancer, Vol 24, Iss 1, Pp 1-12 (2024)
Abstract Background Aldo-keto reductase family 1 member C3 (AKR1C3) is a radioresistance gene in esophageal cancer. This study aimed to investigate the signaling pathways that mediate the regulatory role of AKR1C3 in the radioresistance of esophageal
Externí odkaz:
https://doaj.org/article/01c4ce5e4a9a4676a8d7187d33aa6ad9
Publikováno v:
Journal of Translational Medicine, Vol 22, Iss 1, Pp 1-15 (2024)
Abstract Background The roles of the transcriptional factor SIX2 have been identified in several tumors. However, its roles in gastric cancer (GC) progression have not yet been revealed. Our objective is to explore the impact and underlying mechanism
Externí odkaz:
https://doaj.org/article/81a0d4eb0d2645d2940193d1b2067b0d
Autor:
Man Zhao, Shuo Li, Fengyang Wu, Zhaohong Tang, Lijun Hou, Junai Guo, Yuchun Xin, Xiang Chen, Baojiang Chen
Publikováno v:
Italian Journal of Animal Science, Vol 23, Iss 1, Pp 138-151 (2024)
This study aimed to investigate the effects of curcumin on the expression of antioxidation-related genes in the liver and jejunum and caecum microorganisms of rabbits. A total of 160 IRA rabbits with similar body weight were randomised assigned to 4
Externí odkaz:
https://doaj.org/article/dc13f4a315b8416fa315faf7cc41cbd0
Autor:
Na Young Kim, Dukanya Dukanya, Gautam Sethi, Swamy S Girimanchanaika, Jirui Yang, Omantheswara Nagaraja, Ananda Swamynayaka, Divakar Vishwanath, Keerthikumara Venkantesha, Shreeja Basappa, Arunachalam Chinnathambi, Sulaiman Ali Alharbi, Mahendra Madegowda, Alexey Sukhorukov, Vijay Pandey, Peter E. Lobie, Basappa Basappa, Kwang Seok Ahn
Publikováno v:
Translational Oncology, Vol 49, Iss , Pp 102101- (2024)
Small molecule-driven JNK activation has been found to induce apoptosis and paraptosis in cancer cells. Herein pharmacological effects of synthetic oxazine (4aS, 7aS)-3-((4-(4‑chloro-2-fluorophenyl)piperazin-1-yl)methyl)-4-phenyl-4, 4a, 5, 6, 7, 7a
Externí odkaz:
https://doaj.org/article/6719bc3a38394d8688d5d7884b2aea4a
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
BackgroundGastrodia elata Blume, also called Tian Ma (TM), has been used to treat stroke for centuries. However, its effects on inflammation in acute cerebral ischemic injury and underlying mechanisms involved in microglial polarization remain unknow
Externí odkaz:
https://doaj.org/article/534554f0a39642849e29df8850841f1e
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 12 (2024)
Intervertebral disc degeneration (IDD) serves as the underlying pathology for various spinal degenerative conditions and is a primary contributor to low back pain (LBP). Recent studies have revealed a strong correlation between IDD and biological pro
Externí odkaz:
https://doaj.org/article/d9216f2ed0c940549e8f531b74e69c16
Publikováno v:
Heliyon, Vol 10, Iss 17, Pp e37344- (2024)
Background: Cholangiocarcinoma (CCA) is the second most common primary malignancy of the liver and is associated with poor prognosis. Despite the emerging role of glycine amidinotransferase (GATM) in cancer development, its function in CCA remains el
Externí odkaz:
https://doaj.org/article/44da14ed1d8e49908a181cf718484e85
Autor:
Eun Sun Park, Yo Sep Hwang, Hyung Won Ryu, Hyang Ran Yoon, Jong-Tae Kim, Jong-Seok Lim, Hee Jun Cho, Hee Gu Lee
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
Paulownin, a natural compound derived from Paulownia tomentosa wood, exhibits various physiological functions, including anti-bacterial and anti-fungal effects. However, the impact of paulownin on natural killer (NK) cell immune activity remains larg
Externí odkaz:
https://doaj.org/article/c0b6e03c8cf1488e91da13a0a661621b
Therapeutic potential of ASK1 activators in cancer treatment: Current insights and future directions
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 178, Iss , Pp 117214- (2024)
Apoptosis signal-regulated kinase 1 (ASK1) is a member of the mitogen-activated protein kinase kinase (MAP3K) family, whose activation and regulation are intricately associated with apoptosis. ASK1 is activated in response to oxidative stress, among
Externí odkaz:
https://doaj.org/article/008d9042ae1647d8b83f1564007d11b2