Nerve growth factor promotes differentiation and protects the oligodendrocyte precursor cells from in vitro hypoxia/ischemia

Autor: Vito Antonio Baldassarro, Maura Cescatti, Maria Luisa Rocco, Luigi Aloe, Luca Lorenzini, Luciana Giardino, Laura Calzà

Publikováno v: Frontiers in Neuroscience, Vol 17 (2023)

IntroductionNerve growth factor (NGF) is a pleiotropic molecule acting on different cell types in physiological and pathological conditions. However, the effect of NGF on the survival, differentiation and maturation of oligodendrocyte precursor cells

Externí odkaz: https://doaj.org/article/71a10ef3f8424586b7c8629e8f6b1636

Targeting the Interaction of GABAB Receptors With CHOP After an Ischemic Insult Restores Receptor Expression and Inhibits Progressive Neuronal Death

Autor: Musadiq A. Bhat, Abolghasem Esmaeili, Elena Neumann, Karthik Balakrishnan, Dietmar Benke

Publikováno v: Frontiers in Pharmacology, Vol 13 (2022)

GABAB receptors control neuronal excitability via slow and prolonged inhibition in the central nervous system. One important function of GABAB receptors under physiological condition is to prevent neurons from shifting into an overexcitation state wh

Externí odkaz: https://doaj.org/article/00894417e80c43efa4fc68ec0fd17575

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Specific rescue by ortho-hydroxy atorvastatin of cortical GABAergic neurons from previous oxygen/glucose deprivation: role of pCREB

Autor: Jovita Ponce, Octavi Martí-Sistac, Teresa Gasull, Antoni Dávalos, Nuria DeGregorio-Rocasolano, Verónica Guirao

Publikováno v: Journal of Neurochemistry
r-IGTP. Repositorio Institucional de Producción Científica del Instituto de Investigación Germans Trias i Pujol
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The statin atorvastatin (ATV) given as a post-treatment has been reported beneficial in stroke, although the mechanisms involved are not well understood so far. Here, we investigated invitro the effect of post-treatment with ATV and its main bioactiv

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd427af1fb1893d614c9a6108fc287e9
https://doi.org/10.1111/jnc.14210