Zobrazeno 1 - 10
of 5 907
pro vyhledávání: '"oxygen–glucose deprivation"'
Publikováno v:
陆军军医大学学报, Vol 46, Iss 15, Pp 1763-1771 (2024)
Objective To investigate the protective effect of oxygen-glucose deprivation preconditioning (OGDPC) on PC12 cells damaged with oxygen-glucose deprivation/reperfusion (OGD/R) and its underlying mechanism. Methods PC12 cells were randomly divided into
Externí odkaz:
https://doaj.org/article/8923fc747cb34f7e93a46e90e9e2eb74
Autor:
Karl Schoknecht, Jens Eilers
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-10 (2024)
Abstract Investigating blood-brain barrier (BBB) dysfunction has become a pre-clinical and clinical research focus as it accompanies many neurological disorders. Nevertheless, knowledge of how diagnostic BBB tracers cross the endothelium from blood-t
Externí odkaz:
https://doaj.org/article/45c7c33324294e3b93b55bc7e426cb3e
Publikováno v:
Fluids and Barriers of the CNS, Vol 21, Iss 1, Pp 1-11 (2024)
Abstract Background Neurovascular deficits and blood-brain barrier (BBB) dysfunction are major hallmarks of brain trauma and neurodegenerative diseases. Oxidative stress is a prominent contributor to neurovascular unit (NVU) dysfunction and can propa
Externí odkaz:
https://doaj.org/article/8d19da83d2eb481bbbae4c4b44e9816e
Publikováno v:
Brain Research Bulletin, Vol 220, Iss , Pp 111152- (2025)
Objective: Spinal cord injury (SCI) is a debilitating condition that often results in paralysis and lifelong medical challenges. Research has shown that epigenetic modifications, particularly histone acetylation, play a role in neuroprotection follow
Externí odkaz:
https://doaj.org/article/78492c1c61af49faa128b96a26b46fd4
Autor:
Jiaxuan He, Siyuan Li, Yunpeng Teng, Hongfei Xiong, Zhuang Wang, Xiaoyao Han, Wei Gong, Ya Gao
Publikováno v:
Autoimmunity, Vol 57, Iss 1 (2024)
Dual-specificity phosphatase 12 (DUSP12) is abnormally expressed under various pathological conditions and plays a crucial role in the pathological progression of disorders. However, the role of DUSP12 in cerebral ischaemia/reperfusion injury has not
Externí odkaz:
https://doaj.org/article/296751f4cf244c938fe9fae03bf73efe
Autor:
Mara Ioana Ionescu, Ioana-Florentina Grigoras, Rosana-Bristena Ionescu, Diana Maria Chitimus, Robert Mihai Haret, Bogdan Ianosi, Mihai Ceanga, Ana-Maria Zagrean
Publikováno v:
Current Issues in Molecular Biology, Vol 46, Iss 6, Pp 6223-6236 (2024)
Perinatal asphyxia (PA) and hypoxic-ischemic encephalopathy can result in severe, long-lasting neurological deficits. In vitro models, such as oxygen–glucose deprivation (OGD), are used experimentally to investigate neuronal response to metabolic s
Externí odkaz:
https://doaj.org/article/84096902ce4843879c40796d44cec439
Publikováno v:
IBRO Neuroscience Reports, Vol 16, Iss , Pp 535-541 (2024)
Background: Ischaemic stroke can lead to many complications, but treatment options are limited. Icariin is a traditional Chinese medicine with reported neuroprotective effects against ischaemic cerebral injury; however, the underlying mechanisms by w
Externí odkaz:
https://doaj.org/article/10952d42ec3840258908148afe329e51
Akademický článek
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Publikováno v:
In Brain Research 1 March 2024 1826
Autor:
Xianglong Li, Kaiguo Xia, Chuanhong Zhong, Xiangzhou Chen, Fubing Yang, Ligang Chen, Jian You
Publikováno v:
Brain Research Bulletin, Vol 216, Iss , Pp 111050- (2024)
Background: G protein-coupled receptor 68 (GPR68), an orphan receptor, has emerged as a promising therapeutic target for mitigating neuronal inflammation and oxidative damage. This study explores the protective mechanisms of GPR68 in cerebral ischemi
Externí odkaz:
https://doaj.org/article/ebb7b104ff1f4ac79bed4c11b9ca70c4