Zobrazeno 1 - 10
of 151
pro vyhledávání: '"oxidoreductase inhibitor"'
Autor:
Yukio Maruyama, Takanori Kumagai, Naoki Sugano, Shigetaka Yoshida, Kimiyoshi Ichida, Shunya Uchida
Publikováno v:
Renal Replacement Therapy, Vol 7, Iss 1, Pp 1-11 (2021)
Abstract Background Whether uric acid (UA)-lowering therapy (ULT) is effective in reducing the progression of renal dysfunction in patients with chronic kidney disease (CKD) remains controversial. Since several advances have been made in therapies fo
Externí odkaz:
https://doaj.org/article/037e06d7105a4f6e8900c9d7ecd61caa
Publikováno v:
Molecular Medicine, Vol 25, Iss 1, Pp 1-13 (2019)
Abstract Background Clinically applied as anti-gout drugs, xanthine oxidoreductase (XOR) inhibitors, especially the potent, selective, non-purine-analog XOR inhibitors febuxostat and topiroxostat, exert organ-protective effects. We tested the hypothe
Externí odkaz:
https://doaj.org/article/f45ce37d13a54e15b566432b41790116
Akademický článek
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Autor:
Kimiyoshi Ichida, Naoki Sugano, Shigetaka Yoshida, Shunya Uchida, Takanori Kumagai, Yukio Maruyama
Publikováno v:
Renal Replacement Therapy, Vol 7, Iss 1, Pp 1-11 (2021)
Background Whether uric acid (UA)-lowering therapy (ULT) is effective in reducing the progression of renal dysfunction in patients with chronic kidney disease (CKD) remains controversial. Since several advances have been made in therapies for hyperur
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::209ff71d61356ea1654f42e7586e4780
https://doaj.org/article/037e06d7105a4f6e8900c9d7ecd61caa
https://doaj.org/article/037e06d7105a4f6e8900c9d7ecd61caa
Autor:
Annika Wagner, Johannes C. B. Dietschreit, Bernd Engels, Ute A. Hellmich, Hermann Schindelin, Christian Ochsenfeld, T. Anh Le, Till Opatz, Philipp Klein
Publikováno v:
Angewandte Chemie (International Ed. in English)
The absence of fluorine from most biomolecules renders it an excellent probe for NMR spectroscopy to monitor inhibitor–protein interactions. However, predicting the binding mode of a fluorinated ligand from a chemical shift (or vice versa) has been
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a12ffbeb4137d89e9aac261aebfde156
http://europepmc.org/articles/PMC7496126
http://europepmc.org/articles/PMC7496126
Autor:
Wen Liu, Amy Gustafson, Firoz Jaipuri, Erica VanderPorten, Leanne Goon, Yamin Zhang, Guosheng Wu, Zuhui Zhang, Antonio G. DiPasquale, Xiaokai Li, Angela J. Oh, Lewis J. Gazzard, Seth F. Harris, Jesse Waldo, Roheeth Kumar Pavana, Yichin Liu, Venkata Velvadapu, Cheng Shao, Yuen Po-Wai, Mario R. Mautino, Zhonghua Pei, Hank La, Hima Potturi, Georgette Castanedo, Benjamin D. Sellers, Kevin DeMent, Sanjeev Kumar, Richard Pastor, Rohan Mendonca, Brendan T. Parr
Publikováno v:
ACS Med Chem Lett
[Image: see text] A class of imidazoisoindole (III) heme-binding indoleamine-2,3-dioxygenase (IDO1) inhibitors were optimized via structure-based drug design into a series of tryptophan-2,3-dioxygenase (TDO)-selective inhibitors. Kynurenine pathway m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::701dd22f186bad66eefde1770830d8d6
https://doi.org/10.1021/acsmedchemlett.0c00004
https://doi.org/10.1021/acsmedchemlett.0c00004
Akademický článek
Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.
K zobrazení výsledku je třeba se přihlásit.
Autor:
Jian Lin, M. Katz, S. Ashwell, A.M. Campbell, K.J. Barr, Mark T. Kershaw, Wei Lu, D. Walker, Zhongguo Wang, Angela V. Toms, L. Yao, A. Clarke, R.B. Diebold, H.R. Josephine, Deepali Gotur, A. Ericsson, Christopher J. Dinsmore, G.R. Gustafson, Caravella Justin Andrew, Jennifer Castro
Publikováno v:
Journal of Medicinal Chemistry. 63:1612-1623
Inhibition of mutant IDH1 is being evaluated clinically as a treatment option for oncology. Here we describe the structure-based design and optimization of quinoline lead compounds to identify FT-2102, a potent, orally bioavailable, brain penetrant,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0965a9edfde187ce8dfcfe433ff8a562
https://doi.org/10.1021/acs.jmedchem.9b01423
https://doi.org/10.1021/acs.jmedchem.9b01423
Autor:
James Adams, Richard P. Metz, Angela J. Oh, Firoz Jaipuri, Mario R. Mautino, Agnieszka Marcinowicz, Clarissa Van Allen, Xiaoxia Zhang, Kesharwani Tanay, Jesse Waldo, Seth F. Harris, Sanjeev Kumar
Publikováno v:
Journal of Medicinal Chemistry. 62:6705-6733
A novel class of 5-substituted 5H-imidazo[5,1-a]isoindoles are described as potent inhibitors of indoleamine 2,3-dioxygenase 1 (IDO1). A structure-based drug design approach was used to elaborate the 5H-imidazo[5,1-a]isoindole core and to improve pot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::56875c7c15f56666fae9647d4e37884f
https://doi.org/10.1021/acs.jmedchem.9b00662
https://doi.org/10.1021/acs.jmedchem.9b00662
Autor:
Lawrence J. Marnett, Surajit Banerjee, Kebreab Ghebreselasie, Ansari M. Aleem, Md. Jashim Uddin, Shu Xu, Brenda C. Crews
Publikováno v:
ACS Med Chem Lett
[Image: see text] We report the design, synthesis, and evaluation of a series of harmaline analogs as selective inhibitors of 2-arachidonylglycerol (2-AG) oxygenation over arachidonic acid (AA) oxygenation by purified cyclooxygenase-2 (COX-2). A fuse
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5804d093769f03f436a17caf3536c71c
https://europepmc.org/articles/PMC7549255/
https://europepmc.org/articles/PMC7549255/
