Zobrazeno 1 - 10
of 9 928
pro vyhledávání: '"ovary cells"'
Autor:
Ying Bai, Ivan Domenech Mercadé, Ramy Elgendy, Giulia Lambiase, Sew Peak-Chew, Catarina Franco, Steven W. Wingett, Tim J. Stevens, Luigi Grassi, Noah Hitchcock, Cristina Sayago Ferreira, Diane Hatton, Elizabeth A. Miller, Rajesh K. Mistry
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 27, Iss , Pp 17-31 (2025)
The secretory capacity of Chinese hamster ovary (CHO) cells remains a fundamental bottleneck in the manufacturing of protein-based therapeutics. Unconventional biological drugs with complex structures and processing requirements are particularly prob
Externí odkaz:
https://doaj.org/article/808e407dcb674f72af2e309420f393fc
Autor:
Niels Bauer, Marco Boettger, Styliani Papadaki, Tanja Leitner, Stefan Klostermann, Hubert Kettenberger, Guy Georges, Vincent Larraillet, Dino Gluhacevic von Kruechten, Lars Hillringhaus, Annette Vogt, Simon Ausländer, Oliver Popp
Publikováno v:
Frontiers in Bioengineering and Biotechnology, Vol 12 (2024)
We present a detailed mass spectrometric analysis of three 2 + 1 T-cell bispecific monoclonal antibodies (TCB mAbs), where an unexpected +15.9950 Da mass shift in tryptic peptides was observed. This modification was attributed to the occurrence of 5R
Externí odkaz:
https://doaj.org/article/57438583073e46798b89828262bbeaca
Autor:
Chansik Yoon, Eun‐ji Lee, Dongil Kim, Siyun Joung, Yujin Kim, Heungchae Jung, Yeon‐Gu Kim, Gyun Min Lee
Publikováno v:
Advanced Science, Vol 11, Iss 38, Pp n/a-n/a (2024)
Abstract Rapid and efficient cell line development (CLD) process is essential to expedite therapeutic protein development. However, the performance of widely used glutamine‐based selection systems is limited by low selection efficiency, stringency,
Externí odkaz:
https://doaj.org/article/13334b556d7c4bc09f03606f41401c70
Publikováno v:
Tzu-Chi Medical Journal, Vol 36, Iss 3, Pp 240-250 (2024)
A range of recombinant monoclonal antibodies (rMAbs) have found application in treating diverse diseases, spanning various cancers and immune system disorders. Chinese hamster ovary (CHO) cells have emerged as the predominant choice for producing the
Externí odkaz:
https://doaj.org/article/b145dae6e5ea499ab8c05d4219238be6
Autor:
Bai, Ying a, b, 1, Mercadé, Ivan Domenech a, b, 1, Elgendy, Ramy c, Lambiase, Giulia d, Peak-Chew, Sew a, Franco, Catarina a, Wingett, Steven W. a, Stevens, Tim J. a, Grassi, Luigi b, Hitchcock, Noah b, Ferreira, Cristina Sayago b, Hatton, Diane b, Miller, Elizabeth A. a, ⁎, 2, Mistry, Rajesh K. b, ⁎, 2
Publikováno v:
In Computational and Structural Biotechnology Journal 2025 27:17-31
Autor:
Maryam Jari, Shahriyar Abdoli, Zahra Bazi, Fatemeh Tash Shamsabadi, Farnaz Roshanmehr, Majid Shahbazi
Publikováno v:
AMB Express, Vol 14, Iss 1, Pp 1-11 (2024)
Abstract Chinese Hamster Ovary (CHO) cells are widely employed as host cells for biopharmaceutical production. The manufacturing of biopharmaceuticals poses several challenges, including restricted growth potential and inadequate productivity of the
Externí odkaz:
https://doaj.org/article/64631f6493b44f4d9ac3d82b2570e90f
Autor:
Zhiying Yin, Tingcui Wen, Canya Fu, Junji Li, Quanjun Fang, Xiaoying Gong, Jialing You, Shuangqing Wang, Canjie Zheng
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
IntroductionLimited data were available on the effectivenessfour years after Homo or Hetero prime-boost with 10 μg Hansenulapolymorpha recombinant hepatitis B vaccine (HepB-HP) and 20 μgChinese hamster ovary cell HepB (HepB-CHO).MethodsA crosssecti
Externí odkaz:
https://doaj.org/article/fd8a5145130a4b0a8a1f61b7c01b1bbc
Akademický článek
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Publikováno v:
Frontiers in Bioengineering and Biotechnology, Vol 12 (2024)
Background: Investigating the metabolic behaviour of different cellular phenotypes, i.e., good/bad grower and/or producer, in production culture is important to identify the key metabolite(s)/pathway(s) that regulate cell growth and/or recombinant pr
Externí odkaz:
https://doaj.org/article/877f7057b0d248d7a8fdcfd78b89fe14
Autor:
Erica J. Fratz-Berilla, Casey Kohnhorst, Nicholas Trunfio, Xin Bush, Aron Gyorgypal, Cyrus Agarabi
Publikováno v:
Heliyon, Vol 10, Iss 3, Pp e25512- (2024)
Culture pH is a critical process parameter during CHO cell bioreactor operations that is key for proper cell growth, protein production, and maintaining the critical quality attributes of a monoclonal antibody drug substance. The traditional means of
Externí odkaz:
https://doaj.org/article/acbdf2b755b546b48268b58abee6b86f