Anti-inflammatory and Oto-Protective Effect of the Small Heat Shock Protein Alpha B-Crystallin (HspB5) in Experimental Pneumococcal Meningitis

Autor: Silvia T. Erni, Gabriella Fernandes, Michelle Buri, Michael Perny, Rolf Jan Rutten, Johannes M. van Noort, Pascal Senn, Denis Grandgirard, Marta Roccio, Stephen L. Leib

Publikováno v: Frontiers in Neurology, Vol 10 (2019)

Sensorineural hearing loss is the most common long-term deficit after pneumococcal meningitis (PM), occurring in up to 30% of surviving patients. The infection and the following overshooting inflammatory host response damage the vulnerable sensory ce

Externí odkaz: https://doaj.org/article/2bc8416081e34a35ac71fa5bb7b139d3

Interleukin-10 Attenuates Hypochlorous Acid-Mediated Cytotoxicity to HEI-OC1 Cochlear Cells

Autor: David J. Lim, Martin Mwangi, Sung K. Moon, Hun Yi Park, Raekil Park, Sung Hee Kil, David Phak

Publikováno v: Mwangi, M; Kil, S-H; Phak, D; Park, HY; Lim, DJ; Park, R; et al.(2017). Interleukin-10 Attenuates Hypochlorous Acid-Mediated Cytotoxicity to HEI-OC1 Cochlear Cells. FRONTIERS IN CELLULAR NEUROSCIENCE, 11. doi: 10.3389/fncel.2017.00314. UCLA: Retrieved from: http://www.escholarship.org/uc/item/1j84t9rc
Frontiers in Cellular Neuroscience
Frontiers in Cellular Neuroscience, Vol 11 (2017)

Inflammatory reaction plays a crucial role in the pathophysiology of acquired hearing loss such as ototoxicity and labyrinthitis. In our earlier work, we showed the pivotal role of otic fibrocytes in cochlear inflammation and the critical involvement

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ea822513ae1f3cdfd491146779220a7
https://doi.org/10.3389/fncel.2017.00314

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