Zobrazeno 1 - 10
of 64
pro vyhledávání: '"osteoblast (OB)"'
Publikováno v:
Frontiers in Physiology, Vol 13 (2022)
Amino acids have recently emerged as important regulators of osteoblast differentiation and bone formation. Osteoblasts require a continuous supply of amino acids to sustain biomass production to fuel cell proliferation, osteoblast differentiation an
Externí odkaz:
https://doaj.org/article/aafa3112cbdb4c6dbb81c13774be7717
Autor:
Elliot Ballato, Fnu Deepika, Mia Prado, Vittoria Russo, Virginia Fuenmayor, Siresha Bathina, Dennis T. Villareal, Clifford Qualls, Reina Armamento-Villareal
Publikováno v:
Frontiers in Endocrinology, Vol 13 (2022)
IntroductionType 2 diabetes mellitus (T2DM) is well-known to be associated with normal bone density but, concurrently, low bone turnover and increased risk for fracture. One of the proposed mechanisms is possible derangement in bone precursor cells,
Externí odkaz:
https://doaj.org/article/d437cdb185ca47dbb045bf76489c258f
Autor:
Terry G. Dadzie, Alanna C. Green
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
Multiple myeloma is an incurable haematological cancer. The increase in targeted therapies has improved the number of myeloma patients achieving a complete response and improved progression-free survival following therapy. However, a low level of dis
Externí odkaz:
https://doaj.org/article/5d37acfcd74d475fb707ce16f7d117ce
Publikováno v:
Frontiers in Endocrinology, Vol 13 (2022)
Osteoporosis is a bone metabolic disorder characterized by decreased bone density and deteriorated microstructure, which increases the risk of fractures. The imbalance between bone formation and bone resorption results in the occurrence and progressi
Externí odkaz:
https://doaj.org/article/ec681d798a9d46c7aeef76c47a4a37c1
Autor:
Xenia G. Borggaard, Malene H. Nielsen, Jean-Marie Delaisse, Christina M. Andreasen, Thomas L. Andersen
Publikováno v:
Frontiers in Molecular Biosciences, Vol 9 (2022)
The strictly regulated bone remodeling process ensures that osteoblastic bone formation is coupled to osteoclastic bone resorption. This coupling is regulated by a panel of coupling factors, including clastokines promoting the recruitment, expansion,
Externí odkaz:
https://doaj.org/article/cbb3ebbbab6049a097135149ac2d3c11
Autor:
Gongsheng Yuan, Shuying Yang
Publikováno v:
Frontiers in Endocrinology, Vol 13 (2022)
Regulator of G protein signaling (RGS) proteins are critical negative molecules of G protein-coupled receptor (GPCR) signaling, which mediates a variety of biological processes in bone homeostasis and diseases. The RGS proteins are divided into nine
Externí odkaz:
https://doaj.org/article/a5ac1267f01a42fa911b18305361c8d4
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
Several studies have shown that the G-protein coupled cannabinoid receptor CB2 and its interaction partner p62 are molecularly involved in bone remodeling processes. Pharmacological activation of the CB2 receptor enhanced bone volume in postmenopausa
Externí odkaz:
https://doaj.org/article/dda08752f5ae4acca6f371d922eee330
Autor:
Koh Meng Aw Yong, Eric Horst, Dylan Neale, Sonya Royzenblat, Joerg Lahann, Colin Greineder, Megan Weivoda, Geeta Mehta, Evan T. Keller
Publikováno v:
Frontiers in Bioengineering and Biotechnology, Vol 10 (2022)
The bone is a mechanosensitive organ that is also a common metastatic site for prostate cancer. However, the mechanism by which the tumor interacts with the bone microenvironment to further promote disease progression remains to be fully understood.
Externí odkaz:
https://doaj.org/article/40d117a112a846d7a95c8e528cfd79d6
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2021)
Inflammatory osteolysis is a pathological skeletal disease associated with not only the production of inflammatory cytokines but also local oxidative status. Excessive reactive oxygen species (ROS) promote bone resorption by osteoclasts and induce th
Externí odkaz:
https://doaj.org/article/0aa962eeffde430aa57d3053d516be92
Publikováno v:
Frontiers in Endocrinology, Vol 12 (2021)
Bone tissue is organized at the molecular level to resist fracture with the minimum of bone material. This implies that several modifications of the extracellular matrix, including enzymatic collagen crosslinking, take place. We previously highlighte
Externí odkaz:
https://doaj.org/article/e732acc091b9498c95cfb04b0e84653e