In vitro and in silico characterization of the transport of selected perfluoroalkyl carboxylic acids and perfluoroalkyl sulfonic acids by human organic anion transporter 1 (OAT1), OAT2 and OAT3.

Autor: Louisse J; Wageningen Food Safety Research, Wageningen University and Research, Wageningen, the Netherlands. Electronic address: jochem.louisse@efsa.europa.eu., Pedroni L; Department of Food and Drug, University of Parma, Parma 43124, Italy., van den Heuvel JJMW; Division of Pharmacology and Toxicology, Department of Pharmacy, Radboud University Medical Center, Nijmegen, the Netherlands., Rijkers D; Wageningen Food Safety Research, Wageningen University and Research, Wageningen, the Netherlands., Leenders L; Wageningen Food Safety Research, Wageningen University and Research, Wageningen, the Netherlands., Noorlander A; Wageningen Food Safety Research, Wageningen University and Research, Wageningen, the Netherlands., Punt A; Wageningen Food Safety Research, Wageningen University and Research, Wageningen, the Netherlands., Russel FGM; Division of Pharmacology and Toxicology, Department of Pharmacy, Radboud University Medical Center, Nijmegen, the Netherlands., Koenderink JB; Division of Pharmacology and Toxicology, Department of Pharmacy, Radboud University Medical Center, Nijmegen, the Netherlands., Dellafiora L; Department of Food and Drug, University of Parma, Parma 43124, Italy. Electronic address: luca.dellafiora@unipr.it.

Publikováno v: Toxicology [Toxicology] 2024 Dec; Vol. 509, pp. 153961. Date of Electronic Publication: 2024 Sep 27.

Effect of Organic Anion Transporting Polypeptide 1B1 on Plasma Concentration Dynamics of Clozapine in Patients with Treatment-Resistant Schizophrenia.

Autor: Sato T; Department of Pharmaceutical Sciences, Tohoku University Hospital, Sendai 980-8574, Japan., Kawabata T; Graduate School of Information Sciences, Tohoku University, Sendai 980-8578, Japan., Kumondai M; Department of Pharmaceutical Sciences, Tohoku University Hospital, Sendai 980-8574, Japan., Hayashi N; Faculty of Pharmaceutical Sciences, Tohoku University, Sendai 980-8578, Japan., Komatsu H; Department of Psychiatry, Tohoku University Hospital, Sendai 980-8574, Japan., Kikuchi Y; Department of Psychiatry, Graduate School of Medicine, Tohoku University, Sendai 980-8575, Japan., Onoguchi G; Department of Psychiatry, Tohoku University Hospital, Sendai 980-8574, Japan.; Department of Psychiatry, Graduate School of Medicine, Tohoku University, Sendai 980-8575, Japan., Sato Y; Department of Pharmaceutical Sciences, Tohoku University Hospital, Sendai 980-8574, Japan., Nanatani K; Advanced Research Center for Innovations in Next-Generation Medicine, Tohoku University, Sendai 980-8573, Japan.; Tohoku Medical Megabank Organization, Tohoku University, Sendai 980-8573, Japan., Hiratsuka M; Department of Pharmaceutical Sciences, Tohoku University Hospital, Sendai 980-8574, Japan.; Faculty of Pharmaceutical Sciences, Tohoku University, Sendai 980-8578, Japan.; Advanced Research Center for Innovations in Next-Generation Medicine, Tohoku University, Sendai 980-8573, Japan.; Tohoku Medical Megabank Organization, Tohoku University, Sendai 980-8573, Japan., Maekawa M; Department of Pharmaceutical Sciences, Tohoku University Hospital, Sendai 980-8574, Japan.; Faculty of Pharmaceutical Sciences, Tohoku University, Sendai 980-8578, Japan.; Advanced Research Center for Innovations in Next-Generation Medicine, Tohoku University, Sendai 980-8573, Japan., Yamaguchi H; Department of Pharmacy, Yamagata University Hospital, Yamagata 990-9585, Japan.; Graduate School of Medical Science, Yamagata University, Yamagata 990-9585, Japan., Abe T; Division of Nephrology, Endocrinology, and Vascular Medicine, Graduate School of Medicine, Tohoku University, Sendai 980-8574, Japan.; Division of Medical Science, Graduate School of Biomedical Engineering, Tohoku University, Sendai 980-8579, Japan.; Department of Clinical Biology and Hormonal Regulation, Graduate School of Medicine, Tohoku University, Sendai 980-8575, Japan., Tomita H; Department of Psychiatry, Tohoku University Hospital, Sendai 980-8574, Japan.; Department of Psychiatry, Graduate School of Medicine, Tohoku University, Sendai 980-8575, Japan., Mano N; Department of Pharmaceutical Sciences, Tohoku University Hospital, Sendai 980-8574, Japan.; Faculty of Pharmaceutical Sciences, Tohoku University, Sendai 980-8578, Japan.

Publikováno v: International journal of molecular sciences [Int J Mol Sci] 2024 Dec 09; Vol. 25 (23). Date of Electronic Publication: 2024 Dec 09.

Recent Progress and Future Perspectives on Anti-Hyperuricemic Agents.

Autor: Sun Z; Guangdong Provincial Key Laboratory of New Drug Screening, NMPA Key Laboratory for Research and Evaluation of Drug Metabolism, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou 510515, China., Zhang X; Guangdong Provincial Key Laboratory of New Drug Screening, NMPA Key Laboratory for Research and Evaluation of Drug Metabolism, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou 510515, China., Zhao Z; Guangdong Provincial Key Laboratory of New Drug Screening, NMPA Key Laboratory for Research and Evaluation of Drug Metabolism, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou 510515, China., Li X; Chengdu Easton Biopharmaceuticals Co., Ltd., Chengdu 611731, China., Pang J; Guangdong Provincial Key Laboratory of New Drug Screening, NMPA Key Laboratory for Research and Evaluation of Drug Metabolism, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou 510515, China., Chen J; Guangdong Provincial Key Laboratory of New Drug Screening, NMPA Key Laboratory for Research and Evaluation of Drug Metabolism, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou 510515, China.

Publikováno v: Journal of medicinal chemistry [J Med Chem] 2024 Nov 28; Vol. 67 (22), pp. 19966-19987. Date of Electronic Publication: 2024 Nov 08.

Coproporphyrin-I as a Selective OATP1B Biomarker Can Be Used to Delineate the Mechanisms of Complex Drug-Drug Interactions: Cedirogant Case Study.

Autor: Kikuchi R; Quantitative, Translational and ADME Sciences, AbbVie Inc., North Chicago, Illinois, USA., Qian Y; Clinical Pharmacology, AbbVie Inc., North Chicago, Illinois, USA., Badawi M; Clinical Pharmacology, AbbVie Inc., North Chicago, Illinois, USA., Savaryn JP; Quantitative, Translational and ADME Sciences, AbbVie Inc., North Chicago, Illinois, USA., Gannu S; Quantitative, Translational and ADME Sciences, AbbVie Inc., North Chicago, Illinois, USA., Eldred A; Immunology Development, AbbVie Inc., North Chicago, Illinois, USA., Hao S; Discovery and Exploratory Statistics, AbbVie Inc., North Chicago, Illinois, USA., Salem AH; Clinical Pharmacology, AbbVie Inc., North Chicago, Illinois, USA.; Clinical Pharmacy, Ain Shams University, Cairo, Egypt., Liu W; Clinical Pharmacology, AbbVie Inc., North Chicago, Illinois, USA., Klein CE; Clinical Pharmacology, AbbVie Inc., North Chicago, Illinois, USA., Mohamed MF; Clinical Pharmacology, AbbVie Inc., North Chicago, Illinois, USA.

Publikováno v: Clinical pharmacology and therapeutics [Clin Pharmacol Ther] 2024 Nov; Vol. 116 (5), pp. 1334-1342. Date of Electronic Publication: 2024 Aug 05.

Characterization and Prediction of Organic Anion Transporting Polypeptide 1B Activity in Prostate Cancer Patients on Abiraterone Acetate Using Endogenous Biomarker Coproporphyrin I.

Autor: Wang Z; Department of Pharmacy and Pharmaceutical Sciences (Zite.W., K.H.Y.L., E.J.Y.C., E.C.Y.C.) and Department of Surgery, Yong Loo Lin School of Medicine (S.M.T., R.P., E.C.), National University of Singapore, Singapore; Department of Urology (P.C.T., Ziti.W., Q.H.W., W.C.T., A.K., E.C.) and Department of Pharmacy (P.T.W., F.L.), National University Hospital, National University Health System, Singapore; Department of Haematology-Oncology, National University Cancer Institute, Singapore (A.S.C.W.); and National University Cancer Institute, Singapore (P.T.W.)., Luk KHY; Department of Pharmacy and Pharmaceutical Sciences (Zite.W., K.H.Y.L., E.J.Y.C., E.C.Y.C.) and Department of Surgery, Yong Loo Lin School of Medicine (S.M.T., R.P., E.C.), National University of Singapore, Singapore; Department of Urology (P.C.T., Ziti.W., Q.H.W., W.C.T., A.K., E.C.) and Department of Pharmacy (P.T.W., F.L.), National University Hospital, National University Health System, Singapore; Department of Haematology-Oncology, National University Cancer Institute, Singapore (A.S.C.W.); and National University Cancer Institute, Singapore (P.T.W.)., Cheong EJY; Department of Pharmacy and Pharmaceutical Sciences (Zite.W., K.H.Y.L., E.J.Y.C., E.C.Y.C.) and Department of Surgery, Yong Loo Lin School of Medicine (S.M.T., R.P., E.C.), National University of Singapore, Singapore; Department of Urology (P.C.T., Ziti.W., Q.H.W., W.C.T., A.K., E.C.) and Department of Pharmacy (P.T.W., F.L.), National University Hospital, National University Health System, Singapore; Department of Haematology-Oncology, National University Cancer Institute, Singapore (A.S.C.W.); and National University Cancer Institute, Singapore (P.T.W.)., Tham SM; Department of Pharmacy and Pharmaceutical Sciences (Zite.W., K.H.Y.L., E.J.Y.C., E.C.Y.C.) and Department of Surgery, Yong Loo Lin School of Medicine (S.M.T., R.P., E.C.), National University of Singapore, Singapore; Department of Urology (P.C.T., Ziti.W., Q.H.W., W.C.T., A.K., E.C.) and Department of Pharmacy (P.T.W., F.L.), National University Hospital, National University Health System, Singapore; Department of Haematology-Oncology, National University Cancer Institute, Singapore (A.S.C.W.); and National University Cancer Institute, Singapore (P.T.W.)., Periaswami R; Department of Pharmacy and Pharmaceutical Sciences (Zite.W., K.H.Y.L., E.J.Y.C., E.C.Y.C.) and Department of Surgery, Yong Loo Lin School of Medicine (S.M.T., R.P., E.C.), National University of Singapore, Singapore; Department of Urology (P.C.T., Ziti.W., Q.H.W., W.C.T., A.K., E.C.) and Department of Pharmacy (P.T.W., F.L.), National University Hospital, National University Health System, Singapore; Department of Haematology-Oncology, National University Cancer Institute, Singapore (A.S.C.W.); and National University Cancer Institute, Singapore (P.T.W.)., Toh PC; Department of Pharmacy and Pharmaceutical Sciences (Zite.W., K.H.Y.L., E.J.Y.C., E.C.Y.C.) and Department of Surgery, Yong Loo Lin School of Medicine (S.M.T., R.P., E.C.), National University of Singapore, Singapore; Department of Urology (P.C.T., Ziti.W., Q.H.W., W.C.T., A.K., E.C.) and Department of Pharmacy (P.T.W., F.L.), National University Hospital, National University Health System, Singapore; Department of Haematology-Oncology, National University Cancer Institute, Singapore (A.S.C.W.); and National University Cancer Institute, Singapore (P.T.W.)., Wang Z; Department of Pharmacy and Pharmaceutical Sciences (Zite.W., K.H.Y.L., E.J.Y.C., E.C.Y.C.) and Department of Surgery, Yong Loo Lin School of Medicine (S.M.T., R.P., E.C.), National University of Singapore, Singapore; Department of Urology (P.C.T., Ziti.W., Q.H.W., W.C.T., A.K., E.C.) and Department of Pharmacy (P.T.W., F.L.), National University Hospital, National University Health System, Singapore; Department of Haematology-Oncology, National University Cancer Institute, Singapore (A.S.C.W.); and National University Cancer Institute, Singapore (P.T.W.)., Wu QH; Department of Pharmacy and Pharmaceutical Sciences (Zite.W., K.H.Y.L., E.J.Y.C., E.C.Y.C.) and Department of Surgery, Yong Loo Lin School of Medicine (S.M.T., R.P., E.C.), National University of Singapore, Singapore; Department of Urology (P.C.T., Ziti.W., Q.H.W., W.C.T., A.K., E.C.) and Department of Pharmacy (P.T.W., F.L.), National University Hospital, National University Health System, Singapore; Department of Haematology-Oncology, National University Cancer Institute, Singapore (A.S.C.W.); and National University Cancer Institute, Singapore (P.T.W.)., Tsang WC; Department of Pharmacy and Pharmaceutical Sciences (Zite.W., K.H.Y.L., E.J.Y.C., E.C.Y.C.) and Department of Surgery, Yong Loo Lin School of Medicine (S.M.T., R.P., E.C.), National University of Singapore, Singapore; Department of Urology (P.C.T., Ziti.W., Q.H.W., W.C.T., A.K., E.C.) and Department of Pharmacy (P.T.W., F.L.), National University Hospital, National University Health System, Singapore; Department of Haematology-Oncology, National University Cancer Institute, Singapore (A.S.C.W.); and National University Cancer Institute, Singapore (P.T.W.)., Kesavan A; Department of Pharmacy and Pharmaceutical Sciences (Zite.W., K.H.Y.L., E.J.Y.C., E.C.Y.C.) and Department of Surgery, Yong Loo Lin School of Medicine (S.M.T., R.P., E.C.), National University of Singapore, Singapore; Department of Urology (P.C.T., Ziti.W., Q.H.W., W.C.T., A.K., E.C.) and Department of Pharmacy (P.T.W., F.L.), National University Hospital, National University Health System, Singapore; Department of Haematology-Oncology, National University Cancer Institute, Singapore (A.S.C.W.); and National University Cancer Institute, Singapore (P.T.W.)., Wong ASC; Department of Pharmacy and Pharmaceutical Sciences (Zite.W., K.H.Y.L., E.J.Y.C., E.C.Y.C.) and Department of Surgery, Yong Loo Lin School of Medicine (S.M.T., R.P., E.C.), National University of Singapore, Singapore; Department of Urology (P.C.T., Ziti.W., Q.H.W., W.C.T., A.K., E.C.) and Department of Pharmacy (P.T.W., F.L.), National University Hospital, National University Health System, Singapore; Department of Haematology-Oncology, National University Cancer Institute, Singapore (A.S.C.W.); and National University Cancer Institute, Singapore (P.T.W.)., Wong PT; Department of Pharmacy and Pharmaceutical Sciences (Zite.W., K.H.Y.L., E.J.Y.C., E.C.Y.C.) and Department of Surgery, Yong Loo Lin School of Medicine (S.M.T., R.P., E.C.), National University of Singapore, Singapore; Department of Urology (P.C.T., Ziti.W., Q.H.W., W.C.T., A.K., E.C.) and Department of Pharmacy (P.T.W., F.L.), National University Hospital, National University Health System, Singapore; Department of Haematology-Oncology, National University Cancer Institute, Singapore (A.S.C.W.); and National University Cancer Institute, Singapore (P.T.W.)., Lim F; Department of Pharmacy and Pharmaceutical Sciences (Zite.W., K.H.Y.L., E.J.Y.C., E.C.Y.C.) and Department of Surgery, Yong Loo Lin School of Medicine (S.M.T., R.P., E.C.), National University of Singapore, Singapore; Department of Urology (P.C.T., Ziti.W., Q.H.W., W.C.T., A.K., E.C.) and Department of Pharmacy (P.T.W., F.L.), National University Hospital, National University Health System, Singapore; Department of Haematology-Oncology, National University Cancer Institute, Singapore (A.S.C.W.); and National University Cancer Institute, Singapore (P.T.W.)., Chiong E; Department of Pharmacy and Pharmaceutical Sciences (Zite.W., K.H.Y.L., E.J.Y.C., E.C.Y.C.) and Department of Surgery, Yong Loo Lin School of Medicine (S.M.T., R.P., E.C.), National University of Singapore, Singapore; Department of Urology (P.C.T., Ziti.W., Q.H.W., W.C.T., A.K., E.C.) and Department of Pharmacy (P.T.W., F.L.), National University Hospital, National University Health System, Singapore; Department of Haematology-Oncology, National University Cancer Institute, Singapore (A.S.C.W.); and National University Cancer Institute, Singapore (P.T.W.) surce@nus.edu.sg phaccye@nus.edu.sg., Chan ECY; Department of Pharmacy and Pharmaceutical Sciences (Zite.W., K.H.Y.L., E.J.Y.C., E.C.Y.C.) and Department of Surgery, Yong Loo Lin School of Medicine (S.M.T., R.P., E.C.), National University of Singapore, Singapore; Department of Urology (P.C.T., Ziti.W., Q.H.W., W.C.T., A.K., E.C.) and Department of Pharmacy (P.T.W., F.L.), National University Hospital, National University Health System, Singapore; Department of Haematology-Oncology, National University Cancer Institute, Singapore (A.S.C.W.); and National University Cancer Institute, Singapore (P.T.W.) surce@nus.edu.sg phaccye@nus.edu.sg.

Publikováno v: Drug metabolism and disposition: the biological fate of chemicals [Drug Metab Dispos] 2024 Oct 16; Vol. 52 (11), pp. 1356-1362. Date of Electronic Publication: 2024 Oct 16.