Zobrazeno 1 - 10
of 4 307
pro vyhledávání: '"organ on a chip"'
Publikováno v:
Jichu yixue yu linchuang, Vol 44, Iss 9, Pp 1202-1207 (2024)
Traditional in vitro models have inevitable limitations and there are significant differences in assessing drug efficacy and side effects as compared to human trials. Organ-on-a-chip technology simulates human organs in a physiological environment an
Externí odkaz:
https://doaj.org/article/d26a11fa3156432597077320f176c215
Autor:
Yuxuan Zhu, Deming Jiang, Yong Qiu, Xin Liu, Yuhan Bian, Shichao Tian, Xiandi Wang, K. Jimmy Hsia, Hao Wan, Liujing Zhuang, Ping Wang
Publikováno v:
Bioactive Materials, Vol 39, Iss , Pp 59-73 (2024)
Spheroids and organoids have attracted significant attention as innovative models for disease modeling and drug screening. By employing diverse types of spheroids or organoids, it is feasible to establish microphysiological systems that enhance the p
Externí odkaz:
https://doaj.org/article/f9bb21f0f42a49f7bb329c4442ff6ad9
Publikováno v:
EMBO Molecular Medicine, Vol 16, Iss 10, Pp 2299-2321 (2024)
Abstract The human mammary gland represents a highly organized and dynamic tissue, uniquely characterized by postnatal developmental cycles. During pregnancy and lactation, it undergoes extensive hormone-stimulated architectural remodeling, culminati
Externí odkaz:
https://doaj.org/article/3bd0e031c6e740ec847743c0897d255b
Autor:
XIAO Yi, WU Ming, YAO Gang
Publikováno v:
Zhongguo aizheng zazhi, Vol 34, Iss 8, Pp 763-776 (2024)
Tumor organoids, derived from tumor tissues, are three-dimensional structures created in vitro to mimic in vivo tumor growth. They possess comparable genetic lineage and pathological characteristics to the original tumor, making them a promising rese
Externí odkaz:
https://doaj.org/article/ae73c4d278ae49509a69b9d61f37475d
Autor:
Yun Liu, Rumaisa Kamran, Xiaoxia Han, Mengxue Wang, Qiang Li, Daoyue Lai, Keiji Naruse, Ken Takahashi
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-14 (2024)
Abstract In recent years, research on organ-on-a-chip technology has been flourishing, particularly for drug screening and disease model development. Fibroblasts and vascular endothelial cells engage in crosstalk through paracrine signaling and direc
Externí odkaz:
https://doaj.org/article/147a8985935f4e3bb57f1ad5eeb85f0e
Autor:
Sakulrat Mankhong, Thittaya Den-Udom, Tanotnon Tanawattanasuntorn, Thunwarat Suriyun, Kenjiro Muta, Chagriya Kitiyakara, Pimonrat Ketsawatsomkron
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-12 (2024)
Abstract Increased protein-bound uremic toxins (PBUTs) in patients with chronic kidney disease (CKD) are associated with cardiovascular diseases (CVDs); however, whether retention of PBUTs causes CVD remains unclear. Previous studies assessing the im
Externí odkaz:
https://doaj.org/article/8bf9274c8db14364962a1926b08c4a8c
Autor:
Zhi-Min Deng, Fang-Fang Dai, Rui-Qi Wang, Hong-Bing Deng, Tai-Lang Yin, Yan-Xiang Cheng, Gan-Tao Chen
Publikováno v:
Journal of Nanobiotechnology, Vol 22, Iss 1, Pp 1-38 (2024)
Abstract The female reproductive system comprises the internal and external genitalia, which communicate through intricate endocrine pathways. Besides secreting hormones that maintain the female secondary sexual characteristics, it also produces foll
Externí odkaz:
https://doaj.org/article/c3e46c2acffb479a86e939177a6eaa18
Publikováno v:
Materials Today Bio, Vol 29, Iss , Pp 101322- (2024)
Organ-on-a-chip, an in vitro biomimetic microsystem that enables precise regulation and real-time observation of the cell microenvironment, has the potential to become a powerful platform for recapitulating the real microenvironment of organs in vitr
Externí odkaz:
https://doaj.org/article/72a508782fdc474eaf57cdca2165201d
Autor:
Miriam Alb, Kristin Reiche, Michael Rade, Katherina Sewald, Peter Loskill, Madalena Cipriano, Tengku Ibrahim Maulana, Andries D. van der Meer, Huub J. Weener, Laure-Alix Clerbaux, Birgit Fogal, Nirav Patel, Karissa Adkins, Emma Lund, Ethan Perkins, Christopher Cooper, Jan van den Brulle, Hannah Morgan, Tina Rubic-Schneider, Hui Ling, Keith DiPetrillo, Jonathan Moggs, Ulrike Köhl, Michael Hudecek
Publikováno v:
Journal of Immunotoxicology, Vol 21, Iss sup1, Pp S13-S28 (2024)
The success of cellular immunotherapies such as chimeric antigen receptor (CAR) T cell therapy has led to their implementation as a revolutionary treatment option for cancer patients. However, the safe translation of such novel immunotherapies, from
Externí odkaz:
https://doaj.org/article/a47eb06e31b042a382f9b941094ae3ec
Publikováno v:
SLAS Technology, Vol 29, Iss 6, Pp 100219- (2024)
The pharmaceutical and cosmetic industries are encountering a challenge in adopting new study models for product development. there has been a growing interest in organ-on-a-chip systems, and particularly for generating skin models. While numerous al
Externí odkaz:
https://doaj.org/article/4686c399e941412d8e71cd0e5f6576f5