Zobrazeno 1 - 10
of 335
pro vyhledávání: '"organ crosstalk"'
Autor:
André Borges, Luís Bento
Publikováno v:
Annals of Intensive Care, Vol 14, Iss 1, Pp 1-11 (2024)
Abstract Sepsis is a dysregulated immune response to an infection that leads to organ dysfunction. Sepsis-associated organ dysfunction involves multiple inflammatory mechanisms and complex metabolic reprogramming of cellular function. These mechanism
Externí odkaz:
https://doaj.org/article/332826d7482e4df88efe6beac0acc416
Publikováno v:
Resuscitation Plus, Vol 19, Iss , Pp 100719- (2024)
Cardiac arrest and successful resuscitation cause whole-body ischemia and reperfusion, leading to brain injury and extracerebral multiple organ dysfunction. Brain injury is the leading cause of death and long-term disability in resuscitated survivors
Externí odkaz:
https://doaj.org/article/4ae4732cf3124bcb8d69859336fd1ffa
Publikováno v:
BMC Medical Informatics and Decision Making, Vol 24, Iss 1, Pp 1-13 (2024)
Abstract Objective Acute kidney injury (AKI) is a clinical syndrome that occurs as a result of a dramatic decline in kidney function caused by a variety of etiological factors. Its main biomarkers, serum creatinine and urine output, are not effective
Externí odkaz:
https://doaj.org/article/d72a16ca86a149269d88ccb80740d015
Autor:
Taesik Gwag, Sangderk Lee, Zhenyu Li, Alana Newcomb, Josephine Otuagomah, Steven A. Weinman, Ying Liang, Changcheng Zhou, Shuxia Wang
Publikováno v:
JHEP Reports, Vol 6, Iss 4, Pp 101019- (2024)
Background & Aims: Recent studies have implicated platelets, particularly α-granules, in the development of non-alcoholic steatohepatitis (NASH). However, the specific mechanisms involved have yet to be determined. Notably, thrombospondin 1 (TSP1) i
Externí odkaz:
https://doaj.org/article/8012d90658f944b4a8331c2acf09a7f0
Publikováno v:
Frontiers in Endocrinology, Vol 15 (2024)
The intervertebral disc is not isolated from other tissues. Recently, abundant research has linked intervertebral disc homeostasis and degeneration to various systemic diseases, including obesity, metabolic syndrome, and diabetes. Organokines are a g
Externí odkaz:
https://doaj.org/article/6aee13b7427c4208a19de110db9e624e
Publikováno v:
Pharmaceutics, Vol 16, Iss 5, p 592 (2024)
The movement of organic anionic drugs across cell membranes is partly governed by interactions with SLC and ABC transporters in the intestine, liver, kidney, blood–brain barrier, placenta, breast, and other tissues. Major transporters involved incl
Externí odkaz:
https://doaj.org/article/22cfc76d521c43cf8c27e293b99e5443
Publikováno v:
Frontiers in Endocrinology, Vol 14 (2023)
Thermogenic fat, consisting of brown and beige adipocytes, dissipates energy in the form of heat, in contrast to the characteristics of white adipocytes that store energy. Increasing energy expenditure by activating brown adipocytes or inducing beige
Externí odkaz:
https://doaj.org/article/cfa97019a90f4d29bbdb7d9a23ad5192
Autor:
Vitor Ferreira, Cintia Folgueira, María García-Altares, Maria Guillén, Mónica Ruíz-Rosario, Giada DiNunzio, Irma Garcia-Martinez, Rosa Alen, Christoph Bookmeyer, John G. Jones, Juan C. Cigudosa, Pilar López-Larrubia, Xavier Correig-Blanchar, Roger J. Davis, Guadalupe Sabio, Patricia Rada, Ángela M. Valverde
Publikováno v:
Redox Biology, Vol 63, Iss , Pp 102741- (2023)
Olanzapine (OLA), a widely used second-generation antipsychotic (SGA), causes weight gain and metabolic alterations when administered orally to patients. Recently, we demonstrated that, contrarily to the oral treatment which induces weight gain, OLA
Externí odkaz:
https://doaj.org/article/df70da12cc2d45ac97775fe0e1db3edf
Autor:
Junlun Wei, Zhenghao Wang, Tingrui Han, Jiaoting Chen, Yiran Ou, Lan Wei, Xinyue Zhu, Ke Wang, Zhe Yan, Yuan-Ping Han, Xiaofeng Zheng
Publikováno v:
Frontiers in Endocrinology, Vol 14 (2023)
Diabetes mellitus (DM) is a systemic metabolic disease with high mortality and morbidity. Extracellular vesicles (EVs) have emerged as a novel class of signaling molecules, biomarkers and therapeutic agents. EVs-mediated intercellular and interorgan
Externí odkaz:
https://doaj.org/article/5604d543b30d45bfbf3b527b3dd09ff6
Publikováno v:
BMC Nephrology, Vol 23, Iss 1, Pp 1-9 (2022)
Abstract Background In critically ill patients, acute pain occurs frequently, causes sympathetic activation, release of inflammatory mediators, and potential organ dysfunction, with the kidneys potentially sensitive to inflammation-mediated injury. T
Externí odkaz:
https://doaj.org/article/7f70b777d5c54d25975ab5cc5298bf9a