Dose decision of HSK7653 oral immediate release tablets in specific populations clinical trials based on mechanistic physiologically-based pharmacokinetic model

Autor: Zhang, Miao, Zhang, Shudong, Yu, Zhiheng, Yao, Xueting, Lei, Zihan, Yan, Pangke, Wu, Nan, Wang, Xu, Hu, Qin, Liu, Dongyang

Publikováno v: In European Journal of Pharmaceutical Sciences 1 October 2023 189

The Influence of the Polymer Type on the Quality of Newly Developed Oral Immediate-Release Tablets Containing Amiodarone Solid Dispersions Obtained by Hot-Melt Extrusion

Autor: Ancuța Cătălina Fița, Ana Andreea Secăreanu, Adina Magdalena Musuc, Emma Adriana Ozon, Iulian Sarbu, Irina Atkinson, Adriana Rusu, Erand Mati, Valentina Anuta, Anca Lucia Pop

Publikováno v: Molecules, Vol 27, Iss 19, p 6600 (2022)

The present study aims to demonstrate the influence of the polymer-carrier type and proportion on the quality performance of newly developed oral immediate-release tablets containing amiodarone solid dispersions obtained by hot-melt extrusion. Twelve

Externí odkaz: https://doaj.org/article/e7af8bb6ac7f49c580caffc8ba0dcc96

Formulation, Characterisation and Evaluation of the Ethosuximide Oral Immediate Release Tablets

Autor: Kunal K Mehta, Amit B Patil, Anusha Vajhala, Naga Sujan M

Publikováno v: International Journal of Research in Pharmaceutical Sciences. 11:1807-1813

The present study is aimed to formulate, characterization, and evaluate oral immediate-release tablets of Ethosuximide. It is employed as an anti-epileptic agent used in the treatment of epilepsy, in all the age groups who were≥ 1 year. The dosage

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::516535c25d12aa81afa511de0c0d1783
https://doi.org/10.26452/ijrps.v11i2.2084

Key Factors for Improving Predictive Accuracy and Avoiding Overparameterization of the PBPK Absorption Model in Food Effect Studies of Weakly Basic Water-Insoluble Compounds in Immediate Release Formulations.

Autor: Zhang, Miao^1,2 (AUTHOR) mia.zhang@northeastern.edu, Zhang, Shudong³ (AUTHOR), Wang, Lin³ (AUTHOR), Zhang, Zhe³ (AUTHOR), Hu, Qin³ (AUTHOR) huqin@bidc.org.cn, Liu, Dongyang¹ (AUTHOR) huqin@bidc.org.cn

Publikováno v: Pharmaceutics. Oct2024, Vol. 16 Issue 10, p1324. 20p.

Distribution Characteristics and Impacting Factors of Drug CYP Enzymes and Transporters in the Gastrointestinal Tract of Chinese Healthy Subjects.

Autor: Zhang M; Drug Clinical Trial Center, Peking University Third Hospital, Beijing, China.; Department of Pharmaceutical Sciences, School of Pharmacy, Bouve College of Health Sciences, Northeastern University, Boston, Massachusetts, USA., Zhang L; Drug Clinical Trial Center, Peking University Third Hospital, Beijing, China., Suo B; Department of Gastroenterology, Peking University Third Hospital, Beijing, China., Wei Y; Drug Clinical Trial Center, Peking University Third Hospital, Beijing, China.; Department of Radiology, Peking University Third Hospital, Beijing, China., Xu Y; Drug Clinical Trial Center, Peking University Third Hospital, Beijing, China.; College of Pharmacy, The Ohio State University, Columbus, Ohio, USA., Jiang M; Drug Clinical Trial Center, Peking University Third Hospital, Beijing, China.; Department of Pharmaceutical Sciences, School of Pharmacy and Pharmaceutical Sciences, University at Buffalo, The State University of New York, Buffalo, New York, USA., Dong J; Shimadzu China Innovation Center, Beijing, China., Li X; Shimadzu China Innovation Center, Beijing, China., Song Z; Department of Gastroenterology, Peking University Third Hospital, Beijing, China., Liu D; Drug Clinical Trial Center, Peking University Third Hospital, Beijing, China.; Institute of Medical Innovation, Peking University Third Hospital, Beijing, China.

Publikováno v: Clinical pharmacology and therapeutics [Clin Pharmacol Ther] 2024 Nov 24. Date of Electronic Publication: 2024 Nov 24.