An Engineering Platform for Clinical Application of Optogenetic Therapy in Retinal Degenerative Diseases

Autor: Boyuan Yan, Sheila Nirenberg

Publikováno v: IEEE Journal of Translational Engineering in Health and Medicine, Vol 11, Pp 296-305 (2023)

Optogenetics is a new approach for controlling neural circuits with numerous applications in both basic and clinical science. In retinal degenerative diseases, the photoreceptors die, but inner retinal cells remain largely intact. By expressing light

Externí odkaz: https://doaj.org/article/2a65c1ef992646e98c8a61f03ee36416

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Functional Availability of ON-Bipolar Cells in the Degenerated Retina: Timing and Longevity of an Optogenetic Gene Therapy

Autor: Sonja Kleinlogel, Jakub Kralik

Publikováno v: International Journal of Molecular Sciences, Vol 22, Iss 11515, p 11515 (2021)
International Journal of Molecular Sciences
Volume 22
Issue 21
Kralik, Jakub; Kleinlogel, Sonja (2021). Functional Availability of ON-Bipolar Cells in the Degenerated Retina: Timing and Longevity of an Optogenetic Gene Therapy. International journal of molecular sciences, 22(21), p. 11515. MDPI 10.3390/ijms222111515

Degenerative diseases of the retina are responsible for the death of photoreceptors and subsequent loss of vision in patients. Nevertheless, the inner retinal layers remain intact over an extended period of time, enabling the restoration of light sen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79303c5aae8d4465876bc29d19bb5e59

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