Zobrazeno 1 - 10
of 207
pro vyhledávání: '"opioid-induced respiratory depression"'
Autor:
Albert Dahan, Thomas S. Franko, James W. Carroll, David S. Craig, Callie Crow, Jeffrey L. Galinkin, Justin C. Garrity, Joanne Peterson, David B. Rausch
Publikováno v:
Frontiers in Public Health, Vol 12 (2024)
Opioid-induced respiratory depression (OIRD) deaths are ~80,000 a year in the US and are a major public health issue. Approximately 90% of fatal opioid-related deaths are due to synthetic opioids such as fentanyl, most of which is illicitly manufactu
Externí odkaz:
https://doaj.org/article/d4ede227944f44e18d4528fedab8af85
Publikováno v:
Frontiers in Physiology, Vol 14 (2023)
Externí odkaz:
https://doaj.org/article/5e935cd9e657403393fc1f6455d7ddbf
Autor:
Barbara Palkovic, Sanda Mustapic, Ivana Saric, Eckehard A. E. Stuth, Astrid G. Stucke, Edward J. Zuperku
Publikováno v:
Frontiers in Physiology, Vol 14 (2023)
Introduction:In vivo studies using selective, localized opioid antagonist injections or localized opioid receptor deletion have identified that systemic opioids dose-dependently depress respiratory output through effects in multiple respiratory-relat
Externí odkaz:
https://doaj.org/article/1903465c30534bc9ade77857ab3602fa
Publikováno v:
Frontiers in Neuroscience, Vol 17 (2023)
Opioids provide analgesia, as well as modulate sleep and respiration, all by possibly acting on the μ-opioid receptors (MOR). MOR’s are ubiquitously present throughout the brain, posing a challenge for understanding the precise anatomical substrat
Externí odkaz:
https://doaj.org/article/c0d20f10c2b140f08c0355f2dd983836
Publikováno v:
Frontiers in Physiology, Vol 14 (2023)
Opioid medications are the mainstay of pain management but present substantial side-effects such as respiratory depression which can be lethal with overdose. Most opioid drugs, such as fentanyl, act on opioid receptors such as the G-protein-coupled
Externí odkaz:
https://doaj.org/article/5b81ee06ce51475396263d4d1ebb1da1
Autor:
Brian A. Baldo
Publikováno v:
Current Research in Toxicology, Vol 3, Iss , Pp 100078- (2022)
Respiratory depression (RD) is the primary cause of death due to opioids. Opioids bind to mu (µ)-opioid receptors (MORs) encoded by the MOR gene Oprm1, widely expressed in the central and peripheral nervous systems including centers that modulate br
Externí odkaz:
https://doaj.org/article/f081754c58cc48b8a4fc63339356e998
Publikováno v:
JA Clinical Reports, Vol 6, Iss 1, Pp 1-4 (2020)
Abstract Background Most children with trisomy 13 display central apnea, and are prone to opioid-induced respiratory depression. We conducted opioid-free anesthesia for a patient with trisomy 13 and obstructive sleep apnea, and safely extubated the p
Externí odkaz:
https://doaj.org/article/d02645b069aa45d3b182fd87a6649e4f
Akademický článek
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Autor:
Mariana L. Laporta, Michelle O. Kinney, Darrell R. Schroeder, Juraj Sprung, Toby N. Weingarten
Publikováno v:
Biomolecules & Biomedicine, Vol 21, Iss 3 (2021)
To investigate if sex-specific physiologic characteristics could impact postoperative respiratory depression risks in women, we studied incidence and risk factors associated with postoperative respiratory depression in a gynecologic surgical cohort.
Externí odkaz:
https://doaj.org/article/a0623f86bf364d629945214ff02038b3
Publikováno v:
eLife, Vol 10 (2021)
Opioids are perhaps the most effective analgesics in medicine. However, between 1999 and 2018, over 400,000 people in the United States died from opioid overdose. Excessive opioids make breathing lethally slow and shallow, a side-effect called opioid
Externí odkaz:
https://doaj.org/article/3d779d06f0444987a64d0cd42796b504