Intrinsic disorder in the open reading frame 2 of hepatitis E virus: a protein with multiple functions beyond viral capsid

Autor: Zoya Shafat, Anwar Ahmed, Mohammad K. Parvez, Shama Parveen

Publikováno v: Journal of Genetic Engineering and Biotechnology, Vol 21, Iss 1, Pp 1-35 (2023)

Abstract Background Hepatitis E virus (HEV) is the cause of a liver disease hepatitis E. The translation product of HEV ORF2 has recently been demonstrated as a protein involved in multiple functions besides performing its major role of a viral capsi

Externí odkaz: https://doaj.org/article/8978cf74be66478485e1c8eb91aa5371

A ribavirin-induced ORF2 single-nucleotide variant produces defective hepatitis E virus particles with immune decoy function

Autor: Toni Luise Meister, Yannick Brüggemann, Maximilian K. Nocke, Rainer G. Ulrich, Jonas Schuhenn, Kathrin Sutter, André Gömer, Verian Bader, Konstanze F. Winklhofer, Ruth Broering, Lieven Verhoye, Philip Meuleman, Florian W. R. Vondran, Charline Camuzet, Laurence Cocquerel, Daniel Todt, Eike Steinmann

Publikováno v: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America, 2022, ⟨10.1073/pnas.2202653119⟩

International audience; Hepatitis E virus (HEV) is the causative agent of hepatitis E in humans and is the leading cause of enterically transmitted viral hepatitis worldwide. Ribavirin (RBV) is currently the only treatment option for many patients; h

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4bd075dd8023b99f1b3d7c63845e7185
https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&origin=inward&scp=85135978610

Analysis of the codon usage of the ORF2 gene of feline calicivirus

Autor: Bohao Wu, Fanshu Du, Wanting He, Gongjian Wu, Minghui Zang, Zhenlei Zhou

Publikováno v: Infection, Genetics and Evolution

Feline calicivirus (FCV) is a highly prevalent pathogen of the domestic cat that causes acute infections of the oral and upper respiratory tract. The E region of the ORF2 protein is responsible for the induction of virus-neutralizing antibodies, thus

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4dc9a6df518a4f6d18176fd6a7b2842f
http://europepmc.org/articles/PMC7106028

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