Zobrazeno 1 - 10
of 2 297
pro vyhledávání: '"opa1"'
Autor:
Cansu de Muijnck, Lonneke Haer-Wigman, Judith A. M. van Everdingen, Tanya Lushchyk, Pam A. T. Heutinck, Marieke F. van Dooren, Anneke J. A. Kievit, Virginie J. M. Verhoeven, Marleen E. H. Simon, Rosemarie A. Wasmann, Irene C. Notting, Elfride De Baere, Sophie Walraedt, Julie De Zaeytijd, Filip Van den Broeck, Bart P. Leroy, Camiel J. F. Boon, Maria M. van Genderen
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-9 (2024)
Abstract This study aims to describe the ophthalmic characteristics of autosomal dominant (AD) WFS1-associated optic atrophy (AD WFS1-OA), and to explore phenotypic differences with dominant optic atrophy (DOA) caused by mutations in the OPA1-gene. W
Externí odkaz:
https://doaj.org/article/0c0b6eba7aa84c6fa61212f9ff5202a8
Autor:
Melakhessou Mohamed Akram, Eddine Marref Salah, Zahra Doumandji, Ramia Safar, Marref Cherine, Imene Becheker, Olivier Joubert
Publikováno v:
Current Issues in Pharmacy and Medical Sciences, Vol 37, Iss 3, Pp 138-142 (2024)
Atractylis flava Desf. (AF) is common plant that is widely used for its anti- inflammatory and antioxidant properties. The purpose of this study was, therefore, to evaluate the cytotoxic effect and the molecular basis of antioxidant and anti-inflamma
Externí odkaz:
https://doaj.org/article/94d8f310d369463a938cb66b20b15731
Autor:
Léna Meneux, Nadège Feret, Sarah Pernot, Mélissa Girard, Solange Sarkis, Alicia Caballero Megido, Melanie Quiles, Agnès Müller, Laura Fichter, Jerome Vialaret, Christophe Hirtz, Cecile Delettre, Frederic Michon
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-16 (2024)
Abstract Mitochondrial dysfunctions are detrimental to organ metabolism. The cornea, transparent outmost layer of the eye, is prone to environmental aggressions, such as UV light, and therefore dependent on adequate mitochondrial function. While seve
Externí odkaz:
https://doaj.org/article/57bc91c090104b20816d79cafe156427
Publikováno v:
Zhongguo aizheng zazhi, Vol 34, Iss 6, Pp 537-547 (2024)
Background and purpose: Silent information regulator proteins (sirtuins, SIRT) are a class Ⅲ histone deacetylases with nicotinamide adenine dinucleotide (NAD+) as coenzyme. YME1 like 1 ATPase (YME1L1) is essential for the maintenance of mitochondri
Externí odkaz:
https://doaj.org/article/1f3307745bd349eebb666dad2693413b
Autor:
Linlin Liu, Jiahong Wu, Cheng Lu, Yan Ma, Jiayi Wang, Jie Xu, Xiaoli Yang, Xuan Zhang, Hua Wang, Jieyu Xu, Jiehan Zhang
Publikováno v:
Journal of Translational Medicine, Vol 22, Iss 1, Pp 1-16 (2024)
Abstract Background Myocardial ischemia-reperfusion injury (MIRI) is caused by reperfusion after ischemic heart disease. LncRNA Snhg1 regulates the progression of various diseases. N6-methyladenosine (m6A) is the frequent RNA modification and plays a
Externí odkaz:
https://doaj.org/article/5ed7e23cc7254aaf9e0a3b4f83cc4f4a
Autor:
Michela Di Nottia, Teresa Rizza, Enrico Baruffini, Claudia Nesti, Alessandra Torraco, Daria Diodato, Diego Martinelli, Flavio Dal Canto, Alexandru Ionut Gilea, Martina Zoccola, Barbara Siri, Carlo Dionisi-Vici, Enrico Bertini, Filippo Maria Santorelli, Paola Goffrini, Rosalba Carrozzo
Publikováno v:
Frontiers in Genetics, Vol 15 (2024)
BackgroundMitochondria adjust their shape in response to the different energetic and metabolic requirements of the cell, through extremely dynamic fusion and fission events. Several highly conserved dynamin-like GTPases are involved in these processe
Externí odkaz:
https://doaj.org/article/d224f79529b348b7af84168ca8604f37
Autor:
Yohei Nitta, Jiro Osaka, Ryuto Maki, Satoko Hakeda-Suzuki, Emiko Suzuki, Satoshi Ueki, Takashi Suzuki, Atsushi Sugie
Publikováno v:
eLife, Vol 12 (2024)
Autosomal dominant optic atrophy (DOA) is a progressive form of blindness caused by degeneration of retinal ganglion cells and their axons, mainly caused by mutations in the OPA1 mitochondrial dynamin like GTPase (OPA1) gene. OPA1 encodes a dynamin-l
Externí odkaz:
https://doaj.org/article/317f38a29ccb41449afbb6ff8364ca5e
Autor:
Ethan Hung-Hsi Wang, Pei-Hsuan Lin, Pei-Liang Wu, Eugene Yu-Chuan Kang, Laura Liu, Lung-Kun Yeh, Kuan-Jen Chen, Meng-Chang Hsiao, Nan-Kai Wang
Publikováno v:
BMC Medical Genomics, Vol 17, Iss 1, Pp 1-7 (2024)
Abstract Background Copy number variations (CNVs) have emerged as significant contributors to the elusive genetic causality of inherited eye diseases. In this study, we describe a case with optic atrophy and a brain aneurysm, in which a de novo CNV 3
Externí odkaz:
https://doaj.org/article/b54e2527394f4f66959c6e7cd58b701a
Publikováno v:
Redox Report, Vol 29, Iss 1 (2024)
Objectives Diabetic nephropathy (DN) is one of the most serious microvascular complications of diabetes and is the most common cause of end-stage renal disease. Tripartite motif-containing (TRIM) proteins are a large family of E3 ubiquitin ligases th
Externí odkaz:
https://doaj.org/article/7a6cc146dd92474e8ca101cec1734ee9
Autor:
Andrea Castellaneta, Ilario Losito, Vito Porcelli, Serena Barile, Alessandra Maresca, Valentina Del Dotto, Valentina Losacco, Ludovica Sofia Guadalupi, Cosima Damiana Calvano, David C. Chan, Valerio Carelli, Luigi Palmieri, Tommaso R.I. Cataldi
Publikováno v:
Journal of Lipid Research, Vol 65, Iss 6, Pp 100563- (2024)
Depletion or mutations of key proteins for mitochondrial fusion, like optic atrophy 1 (OPA1) and mitofusins 1 and 2 (Mfn 1 and 2), are known to significantly impact the mitochondrial ultrastructure, suggesting alterations of their membranes’ lipid
Externí odkaz:
https://doaj.org/article/6589c03608d146cbb7ee3463e3fa33a0