Zobrazeno 1 - 10
of 963
pro vyhledávání: '"oncogenic signaling"'
Publikováno v:
Cell Division, Vol 19, Iss 1, Pp 1-28 (2024)
Abstract CIP/KIP and INK4 families of Cyclin-dependent kinase inhibitors (CKIs) are well-established cell cycle regulatory proteins whose canonical function is binding to Cyclin-CDK complexes and altering their function. Initial experiments showed th
Externí odkaz:
https://doaj.org/article/fc925f7e928d4793810e068ec2401fea
Autor:
Fang Wang, Kai Fu, Yujue Wang, Can Pan, Xueping Wang, Zeyu Liu, Chuan Yang, Ying Zheng, Xiaopeng Li, Yu Lu, Kenneth Kin Wah To, Chenglai Xia, Jianye Zhang, Zhi Shi, Zeping Hu, Min Huang, Liwu Fu
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 14, Iss 3, Pp 905-952 (2024)
Cancer immunotherapy, exemplified by the remarkable clinical benefits of the immune checkpoint blockade and chimeric antigen receptor T-cell therapy, is revolutionizing cancer therapy. They induce long-term tumor regression and overall survival benef
Externí odkaz:
https://doaj.org/article/06e7be5579fb4a6c9c58d69cff3d3f9c
Publikováno v:
Pharmacological Research, Vol 204, Iss , Pp 107195- (2024)
Eukaryotic elongation factor 1A (eEF1A) is among the most abundant proteins in eukaryotic cells. Evolutionarily conserved across species, eEF1A is in charge of translation elongation for protein biosynthesis as well as a plethora of non-translational
Externí odkaz:
https://doaj.org/article/abd1f28c19a448adb9a62aebd5cd8db1
Akademický článek
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Akademický článek
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Autor:
Sadaqat Ali, Usman Ali, Adeem Qamar, Imran Zafar, Muhammad Yaqoob, Qurat ul Ain, Summya Rashid, Rohit Sharma, Hiba-Allah Nafidi, Yousef A. Bin Jardan, Mohammed Bourhia
Publikováno v:
Frontiers in Chemistry, Vol 11 (2023)
The HRAS gene plays a crucial role in regulating essential cellular processes for life, and this gene's misregulation is linked to the development of various types of cancers. Nonsynonymous single nucleotide polymorphisms (nsSNPs) within the coding r
Externí odkaz:
https://doaj.org/article/2c6b7931710447709cdc8e615f9e93d1
Autor:
Valentina Audrito, Enrico Moiso, Filippo Ugolini, Vincenzo Gianluca Messana, Lorenzo Brandimarte, Ilaria Manfredonia, Simonetta Bianchi, Francesco De Logu, Romina Nassini, Anna Szumera-Ciećkiewicz, Daniela Taverna, Daniela Massi, Silvia Deaglio
Publikováno v:
Journal of Translational Medicine, Vol 20, Iss 1, Pp 1-13 (2022)
Abstract Background Nicotinamide phosphoribosyltransferase (NAMPT), the rate-limiting enzyme in nicotinamide adenine dinucleotide (NAD) biosynthesis, is up-regulated in several cancers, including metastatic melanoma (MM). The BRAF oncogene is mutated
Externí odkaz:
https://doaj.org/article/a7800ab7012943b3b4f65fc9c9073fd7
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
Malignant growth is defined by multiple aberrant cellular features, including metabolic rewiring, inactivation of tumor suppressors and the activation of oncogenes. Even though these features have been described as separate hallmarks, many studies ha
Externí odkaz:
https://doaj.org/article/34bcaf3d66e34ed29b4a2b7591601221
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
BackgroundThe clinical outcomes of breast cancer (BC) are unpredictable due to the high level of heterogeneity and complex immune status of the tumor microenvironment (TME). When set up, multiple long non-coding RNA (lncRNA) signatures tended to be e
Externí odkaz:
https://doaj.org/article/9de9f69f70084b7991d64c8905a227f9
Autor:
Myung-Hoon Han, Kyueng-Whan Min, Yung-Kyun Noh, Jae Min Kim, Jin Hwan Cheong, Je Il Ryu, Yu Deok Won, Seong-Ho Koh, Young Mi Park
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
Glioblastoma multiforme (GBM) is the most malignant brain tumor with an extremely poor prognosis. The Cancer Genome Atlas (TCGA) database has been used to confirm the roles played by 10 canonical oncogenic signaling pathways in various cancers. The p
Externí odkaz:
https://doaj.org/article/0755af6236cb4adab7054efeea8522cb