Metabolic syndrome and cancer risk: The role of xanthine oxidoreductase

Autor: Andrea Bolognesi, Letizia Polito, Maria Giulia Battelli, Massimo Bortolotti

Publikováno v: Redox Biology, Vol 21, Iss, Pp-(2019)
Redox Biology

Obesity and related pathologies such as diabetes and metabolic syndrome are associated with chronic inflammation and cancer. The serum level of xanthine oxidoreductase (XOR) is correlated to obesity-associated metabolic disorders. XOR can play a role

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d48776618e34ec8ca62edd75191c8d15
http://www.sciencedirect.com/science/article/pii/S2213231718310528

The role of heavy metals and polychlorinated biphenyls (PCBs) in the oncogenesis of head and neck tumors and thyroid diseases: a pilot study

Autor: V. Petrosino, Gian Carlo Tenore, Gaetano Motta, Domenico Testa, A. Guariglia, M. Coletta

Publikováno v: Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine. 31(2)

Previous literature has highlighted the mechanisms of molecular toxicity induced by substances such as arsenic, cadmium, chromium, nickel, lead, barium and PCBs. The research was carried out on 20 volunteers, all the patients gave their consent to th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d29548d08af5e7e9a84193625fb3987
https://pubmed.ncbi.nlm.nih.gov/29520558

Exploring the Relationship between Ageing and Cancer: from Translational to Clinical Research

Autor: Falco, Cristina

A better understanding of the physiological and functional changes that occur with aging will enable to improve strategies for treating elderly cancer patients. For istance, hemathological toxicity is a major obstacle to the administration of chemoth

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::95c83c5bfb3faeb18208a0127f19eb08
http://paduaresearch.cab.unipd.it/7671/

SUMO-activating SAE1 transcription is positively regulated by Myc

Autor: AMENTE, STEFANO, MAJELLO, BARBARA, Lavadera M.L., Di Palo G.

Myc protein plays a fundamental role in regulation of cell cycle, proliferation, differentiation and apoptosis by modulating the expression of a large number of targets. Here we report the transactivation ability of the human Myc protein to activate

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______3730::cc0d925993bfcec18bde78ac31d669da
http://hdl.handle.net/11588/459507

SOD3 Decreases Ischemic Injury Derived Apoptosis through Phosphorylation of Erk1/2, Akt, and FoxO3a

Autor: Massimo Santoro, Lilja E. Laatikainen, Maria Domenica Castellone, Juha P. Laurila, Mikko O. Laukkanen, Mariarosaria Incoronato

Publikováno v: PLoS ONE
PLoS ONE, Vol 6, Iss 8, p e24456 (2011)
PloS one 6 (2011). doi:10.1371/journal.pone.0024456
info:cnr-pdr/source/autori:Laatikainen, LE [ 1 ] ; Incoronato, M [ 2 ] ; Castellone, MD [ 3 ] ; Laurila, JP [ 1 ] ; Santoro, M [ 3 ] ; Laukkanen, MO [ 1,2]/titolo:SOD3 Decreases Ischemic Injury Derived Apoptosis through Phosphorylation of Erk1%2F2, Akt, and FoxO3a./doi:10.1371%2Fjournal.pone.0024456/rivista:PloS one/anno:2011/pagina_da:/pagina_a:/intervallo_pagine:/volume:6

BackgroundExtracellular superoxide dismutase (SOD3), which dismutates superoxide anion to hydrogen peroxide, has been shown to reduce the free radical stress derived apoptosis in tissue injuries. Since both superoxide anion and hydrogen peroxide have

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9151e73325adc1932244060875914a3d
http://europepmc.org/articles/PMC3164207