Zobrazeno 1 - 10
of 5 416
pro vyhledávání: '"oligodeoxynucleotide"'
Autor:
Sadaf Bahadori, Zahra Farzaneh, Roya Solhi, Zahra Hajilou, Bahare Shokoohian, Moustapha Hassan, Mustapha Najimi, Massoud Vosough
Publikováno v:
Cell Journal, Vol 26, Iss 8, Pp 505-514 (2024)
Objective: The spliced form of X-box binding protein 1 (XBP1s) is a key transcription factor in the unfolded proteinresponse (UPR), an adaptive mechanism for cell survival. Many studies demonstrated the induced expression ofXBP1s in various cancers,
Externí odkaz:
https://doaj.org/article/e0f1c834cfa34e36956f3934297e4b38
Autor:
Brijesh Yadav, Narayan Prasad, Ravi Shanker Kushwaha, Ankita Singh, Deependra Yadav, Dharmendra Singh Bhadauria, Anupma Kaul
Publikováno v:
Indian Journal of Transplantation, Vol 18, Iss 2, Pp 132-137 (2024)
Background: Mitochondria are semiautonomous cell organelles having its own nucleic acid. Mitochondrial DNA (Mt-DNA) remain in hypomethylated (CpG) state and impose an immunogenic response by binding to the toll-like receptor (TLR-9) through the NF-kB
Externí odkaz:
https://doaj.org/article/31e397bf577d41eeb4d32f99b8223aa0
Autor:
Maria Gagliardi, Rhonda Kean, Bingbing Dai, Jithesh Jose Augustine, Michael Roberts, Jason Fleming, D. Craig Hooper, Ana Tari Ashizawa
Publikováno v:
Biomedicines, Vol 12, Iss 8, p 1901 (2024)
Overexpression and aberrant activation of signal transducer and activator of transcription 3 (STAT3) contribute to tumorigenesis, drug resistance, and tumor-immune evasion, making it a potential cancer therapeutic target. BP1003 is a neutral liposome
Externí odkaz:
https://doaj.org/article/f2009c519c1e47bbb1d16259b222484d
Publikováno v:
Biomolecules, Vol 14, Iss 6, p 709 (2024)
De-differentiation and subsequent increased proliferation and inflammation of vascular smooth muscle cells (VSMCs) is one of the mechanisms of atherogenesis. Maintaining VSMCs in a contractile differentiated state is therefore a promising therapeutic
Externí odkaz:
https://doaj.org/article/90acf1fa022947ad90d48255a8c8b9c3
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
IntroductionRespiratory syncytial virus (RSV) vaccines targeting the fusion glycoprotein (F protein) are highly effective clinically in preventing RSV challenges. The attachment glycoprotein (G protein) is a potentially effective vaccine antigen cand
Externí odkaz:
https://doaj.org/article/5393c2eafe5a423a9bf6fd3b5b7d1638
Autor:
Mi-Gyeong Gwon, Jaechan Leem, Hyun-Jin An, Hyemin Gu, Seongjae Bae, Jong Hyun Kim, Kwan-Kyu Park
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 34, Iss , Pp 102036- (2023)
Atopic dermatitis (AD) is a common inflammatory skin disease caused by an immune disorder. Mast cells are known to be activated and granulated to maintain an allergic reaction, including rhinitis, asthma, and AD. Although hypoxia-inducible factor-1 a
Externí odkaz:
https://doaj.org/article/8fa66ff47c004a729309793f16b22a9f
Renoprotection by Inhibiting Connexin 43 Expression in a Mouse Model of Obesity-Related Renal Injury
Publikováno v:
Diabetes, Metabolic Syndrome and Obesity, Vol Volume 16, Pp 1415-1424 (2023)
Xiaomin An,1,2,* Guohua Li,1,* Shu Wang,1 Tianrun Xie,1 Xiaoxiao Ren,1 Yongli Zhao1 1Department of Pediatrics, The Second Hospital of Dalian Medical University, Dalian, 116027, People’s Republic of China; 2Department of Nephrology, Xi’an
Externí odkaz:
https://doaj.org/article/0fe1b6d0f267478e8d113331ff5b2b76
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 31, Iss , Pp 553-565 (2023)
Homeostatic restoration of an inflammatory response requires quenching of the immune system after pathogen threats vanish. A continued assault orchestrated by host defense results in tissue destruction or autoimmunity. A151 is the epitome of syntheti
Externí odkaz:
https://doaj.org/article/b69edf08eb7d40f583c41e62c6e26e45
Autor:
Koji Umezawa, Rena Ikeda, Taiichi Sakamoto, Yuya Enomoto, Yuma Nihashi, Sayaka Shinji, Takeshi Shimosato, Hiroshi Kagami, Tomohide Takaya
Publikováno v:
BioTech, Vol 13, Iss 2, p 11 (2024)
A myogenetic oligodeoxynucleotide (myoDN), iSN04 (5′-AGA TTA GGG TGA GGG TGA-3′), is a single-stranded 18-base telomeric DNA that serves as an anti-nucleolin aptamer and induces myogenic differentiation, which is expected to be a nucleic acid dru
Externí odkaz:
https://doaj.org/article/17242a6b91614fc2a71b427d78c59071
Autor:
Ling Bai, Lei Zhou, Wei Han, Jingtao Chen, Xiaoyi Gu, Zheng Hu, Yongguang Yang, Wei Li, Xiaoying Zhang, Chao Niu, Yongchong Chen, Hui Li, Jiuwei Cui
Publikováno v:
Journal of Translational Medicine, Vol 21, Iss 1, Pp 1-18 (2023)
Key points TLR9 is not only a prognostic biomarker but also a potential target for B-ALL therapy. C-MYC-mediated BAX activation leads to CpG 685-induced apoptosis in B-ALL.
Externí odkaz:
https://doaj.org/article/d4f394fbb7a74986b8f38af747a7f72a