Zobrazeno 1 - 10
of 4 089
pro vyhledávání: '"off-target"'
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-12 (2024)
Abstract The protein kinases DYRK1A and DYRK1B are pivotal regulators of cell cycle progression by promoting cell cycle exit into quiescence. DYRK1B appears to play a more important role in cancer cell quiescence than DYRK1A, as evidenced by its over
Externí odkaz:
https://doaj.org/article/935b43de979842cb9b78a406a220ef31
Autor:
Carole Shum, Sang Yeon Han, Bhooma Thiruvahindrapuram, Zhuozhi Wang, Jill de Rijke, Benjamin Zhang, Maria Sundberg, Cidi Chen, Elizabeth D. Buttermore, Nina Makhortova, Jennifer Howe, Mustafa Sahin, Stephen W. Scherer
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 23, Iss , Pp 638-647 (2024)
Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)-Cas nucleases and human induced pluripotent stem cell (iPSC) technology can reveal deep insight into the genetic and molecular bases of human biology and disease. Undesired editing ou
Externí odkaz:
https://doaj.org/article/fce05ccaaede435b84e6e74474bfe7f5
Autor:
Jin Liu, Yike Gui, Jingxin Rao, Jingjing Sun, Gang Wang, Qun Ren, Ning Qu, Buying Niu, Zhiyi Chen, Xia Sheng, Yitian Wang, Mingyue Zheng, Xutong Li
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 14, Iss 7, Pp 2927-2941 (2024)
Ensuring drug safety in the early stages of drug development is crucial to avoid costly failures in subsequent phases. However, the economic burden associated with detecting drug off-targets and potential side effects through in vitro safety screenin
Externí odkaz:
https://doaj.org/article/062c5287154b4c81a56d547d7f1470da
Autor:
Allemailem KS, Almatroudi A, Rahmani AH, Alrumaihi F, Alradhi AE, Alsubaiyel AM, Algahtani M, Almousa RM, Mahzari A, Sindi AAA, Dobie G, Khan AA
Publikováno v:
International Journal of Nanomedicine, Vol Volume 19, Pp 5335-5363 (2024)
Khaled S Allemailem,1 Ahmad Almatroudi,1 Arshad Husain Rahmani,1 Faris Alrumaihi,1 Arwa Essa Alradhi,2 Amal M Alsubaiyel,3 Mohammad Algahtani,4 Rand Mohammad Almousa,5 Ali Mahzari,6 Abdulmajeed AA Sindi,7 Gasim Dobie,8 Amjad Ali Khan9 1Department of
Externí odkaz:
https://doaj.org/article/ad2fc492c27f425ba5d76d3c723f2241
Autor:
Hye-Ran Eun, So-Hee Kim, Yoon-Hee Lee, Su-Min Kim, Ye-Jin Lee, Hee-Young Jung, Yi-Gi Min, Hyun Ho Noh, Yongho Shin
Publikováno v:
Ecotoxicology and Environmental Safety, Vol 285, Iss , Pp 117075- (2024)
Off-target pesticide drift in paddy fields following unmanned aerial vehicle (UAV) spraying was evaluated using cellulose deposition samplers (CDSs). An analytical method for quantifying ferimzone Z and E isomers deposited on CDSs was developed using
Externí odkaz:
https://doaj.org/article/dec58a25c32445cfabc5178fcf69cabf
Publikováno v:
HortScience, Vol 59, Iss 11 (2024)
California is the nation’s primary producer of almonds, pistachios, and walnuts, and an important producer of rice. Because of California’s diverse cropping systems, off-target herbicide drift can be a considerable problem, particularly from aeri
Externí odkaz:
https://doaj.org/article/fce8d3cfb0f24fb9a3a3e13e8667b599
Autor:
Wenjie Qin, Yinhua Deng, Huan Ren, Yanling Liu, Ling Liu, Wenhui Liu, Yuxi Zhao, Chen Li, Zhiling Yang
Publikováno v:
Cancer Medicine, Vol 13, Iss 18, Pp n/a-n/a (2024)
Abstract Background and Aims Cardiac glycosides (CGs), traditionally used for heart failure, have shown potential as anti‐cancer agents. This study aims to explore their multifaceted mechanisms in cancer cell biology using proteome integral solubil
Externí odkaz:
https://doaj.org/article/cc1b17f8297848e1a3b4a1e74fc42a3f
Autor:
Sung Ho Moon, Xinping Liu, Christopher M. Jenkins, Beverly Gibson Dilthey, Gary J. Patti, Richard W. Gross
Publikováno v:
Journal of Lipid Research, Vol 65, Iss 9, Pp 100611- (2024)
Mitochondrial fatty acid oxidation serves as an essential process for cellular survival, differentiation, proliferation, and energy metabolism. Numerous studies have utilized etomoxir (ETO) for the irreversible inhibition of carnitine palmitoylcarnit
Externí odkaz:
https://doaj.org/article/33723005d1f749979aecaf473c91d746
Publikováno v:
Heliyon, Vol 10, Iss 17, Pp e36944- (2024)
Daqu is usually produced in an open environment, which makes its quality unstable. The microbial community of Daqu largely determines its quality. Therefore, in order to improve the fermentation characteristics of Daqu, samples were collected from Ji
Externí odkaz:
https://doaj.org/article/8f72425878b540a2aef66f3a08d1d3a0
Autor:
Eric Deneault
Publikováno v:
Current Issues in Molecular Biology, Vol 46, Iss 5, Pp 4147-4185 (2024)
Recent years have witnessed unprecedented progress in therapeutic gene editing, revolutionizing the approach to treating genetic disorders. In this comprehensive review, we discuss the progression of milestones leading to the emergence of the cluster
Externí odkaz:
https://doaj.org/article/480ec0119b1c49458278a41dbf53d952