Zobrazeno 1 - 10
of 632
pro vyhledávání: '"o6-methylguanine"'
Autor:
Vahid Khalaj, Solmaz AghaAmiri, Sukhen C Ghosh, Servando Hernandez Vargas, Majid Momeny, Ali Azhdarinia
Publikováno v:
BioTechniques, Vol 76, Iss 7, Pp 343-351 (2024)
O6-Methylguanine-DNA methyltransferase (MGMT) is a DNA repair enzyme that is overexpressed in certain tumors and is associated with resistance to the DNA alkylating agent temozolomide. MGMT inhibitors show potential in combating temozolomide resistan
Externí odkaz:
https://doaj.org/article/837c587770404699beb6449c35f43eb0
Publikováno v:
Diagnostics, Vol 14, Iss 22, p 2569 (2024)
Isocitrate dehydrogenase (IDH) and O6-methylguanine-DNA methyltransferase (MGMT) genes are critical molecular markers in determining treatment options and predicting the prognosis of adult-type diffuse gliomas. Objectives: this study aimed to investi
Externí odkaz:
https://doaj.org/article/739128de1082411db740a6403b70b7fc
Autor:
Jodie D. Cropper, Dauren S. Alimbetov, Kevin T. G. Brown, Rostislav I. Likhotvorik, Andrew J. Robles, James T. Guerra, Boxue He, Yidong Chen, Youngho Kwon, Raushan T. Kurmasheva
Publikováno v:
Journal of Hematology & Oncology, Vol 15, Iss 1, Pp 1-6 (2022)
Abstract DNA lesions induced by alkylating agents are repaired by two canonical mechanisms, base excision repair dependent on poly(ADP) ribose polymerase 1 (PARP1) and the other mediated by O6-methylguanine (O6meG)-DNA methyltransferase (MGMT) in a s
Externí odkaz:
https://doaj.org/article/5b3757c443a5481e8a6488e272f662ca
Akademický článek
Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.
K zobrazení výsledku je třeba se přihlásit.
Akademický článek
Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.
K zobrazení výsledku je třeba se přihlásit.
Publikováno v:
Jichu yixue yu linchuang, Vol 41, Iss 4, Pp 514-520 (2021)
Objective To investigate whether FM19G11 affects the sensitivity of human-derived malignant glioma cell line T98G to temozolomide (TMZ) and underlying molecular mechanisms. Methods T98G cells were treated with 0, 0.5, 1 and 2 μmol/L of FM19G11 and T
Externí odkaz:
https://doaj.org/article/f27782354137445e95f82047a55f6baa
Publikováno v:
Drug Design, Development and Therapy, Vol Volume 15, Pp 963-971 (2021)
Yahdiana Harahap,1,2 Aurelia Maria Vianney,1 Herman Suryadi1 1Faculty of Pharmacy, Universitas Indonesia, Depok, West Java, 16424, Indonesia; 2Indonesia Defense University, Bogor, 16810, West Java, IndonesiaCorrespondence: Yahdiana Harahap Email yahd
Externí odkaz:
https://doaj.org/article/5026d9600baf4b3f9be51a867985aa03
Autor:
Atsushi Ishida, Hiroki Shichi, Hidenori Fukuoka, Hideki Shiramizu, Naoko Inoshita, Shozo Yamada
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
Aggressive somatotroph pituitary tumor that causes acromegaly is extremely rare and resists conventional treatments such as multiple surgeries, radiotherapies, and various types of somatostatin analogs. Here, we propose a novel treatment option for t
Externí odkaz:
https://doaj.org/article/f493834c855b4a5b91d4058dfb9c405a
Publikováno v:
Journal of Medical Sciences, Vol 40, Iss 6, Pp 257-264 (2020)
Background: Analysis of O6-methylguanine DNA methyltransferase (MGMT) methylation considers as a predictive marker for chemotherapy sensitivity. Mutation in BRAF and Kirsten RAt sarcoma viral oncogene homolog (KRAS) gene is also crucial in colorectal
Externí odkaz:
https://doaj.org/article/6e5e99061c2742969bd8f638a68b24fb
Autor:
Yahdiana Harahap, Athalia Theda Tanujaya, Farhan Nurahman, Aurelia Maria Vianney, Denni Joko Purwanto
Publikováno v:
Heliyon, Vol 7, Iss 7, Pp e07558- (2021)
Cyclophosphamide is a nitrogen mustard class of drugs that are often used in cancer chemotherapy. However, the use of Cyclophosphamide in high doses over a long period has been shown to increase the risk of developing secondary cancer. This can be in
Externí odkaz:
https://doaj.org/article/e636e6c574314b2199ad6b38de2f9517