Zobrazeno 1 - 10
of 3 628
pro vyhledávání: '"o-glcnac"'
Publikováno v:
Guoji Yanke Zazhi, Vol 24, Iss 12, Pp 1882-1887 (2024)
AIM:To analyze the expression changes of O-linked N-acetylglucosamine(O-GlcNAc)glycoprotein in the lens capsule of age-related cataract and diabetic cataract and investigate the role of O-GlcNAc glycoprotein in diabetic cataract.METHODS: The lens cap
Externí odkaz:
https://doaj.org/article/8682b9e3e70146758861efd1fda11db2
Publikováno v:
Molecular Medicine, Vol 30, Iss 1, Pp 1-24 (2024)
Abstract This study investigates the potential molecular mechanisms by which O-GlcNAc modification of YTHDF2 regulates the cell cycle and participates in intervertebral disc degeneration (IDD). We employed transcriptome sequencing to identify genes i
Externí odkaz:
https://doaj.org/article/298142973bb54ec1b72d612b051185cd
Publikováno v:
Acta Biochimica et Biophysica Sinica, Vol 56, Pp 1108-1117 (2024)
Protein glycosylation is a type of protein post-translational modification. One specific example is the modification of proteins with O-linked β-N-acetylglucosamine (O-GlcNAc) and O-linked α-N-acetylgalactosamine (O-GalNAc). Enhanced levels of both
Externí odkaz:
https://doaj.org/article/13db7865abf24c50a5235741e17972ce
Publikováno v:
Journal of Neuroinflammation, Vol 21, Iss 1, Pp 1-17 (2024)
Abstract This study investigated the role of O-GlcNAc cycling in Alzheimer’s disease-related changes in brain pathophysiology induced by chronic REM sleep deprivation (CSD) in mice. CSD increased amyloid beta (Aβ) and p-Tau accumulation and impair
Externí odkaz:
https://doaj.org/article/abc0ea6f7dde469697c1ff0ae81eb59e
Autor:
Samuel S. Boyd, Dakota R. Robarts, Khue Nguyen, Maite Villar, Ibtihal M. Alghusen, Manasi Kotulkar, Aspin Denson, Halyna Fedosyuk, Stephen A. Whelan, Norman C.Y. Lee, John Hanover, Wagner B. Dias, Ee Phie Tan, Steven R. McGreal, Antonio Artigues, Russell H. Swerdlow, Jeffrey A. Thompson, Udayan Apte, Chad Slawson
Publikováno v:
Molecular Metabolism, Vol 90, Iss , Pp 102060- (2024)
Objective: Pharmacologic or genetic manipulation of O-GlcNAcylation, an intracellular, single sugar post-translational modification, are difficult to interpret due to the pleotropic nature of O-GlcNAc and the vast signaling pathways it regulates. Met
Externí odkaz:
https://doaj.org/article/31c888e58b7d4df9804ebed3402bf348
Autor:
Murielle M. Morales, Matthew R. Pratt
Publikováno v:
Open Biology, Vol 14, Iss 10 (2024)
Cells must rapidly adapt to changes in nutrient conditions through responsive signalling cascades to maintain homeostasis. One of these adaptive pathways results in the post-translational modification of proteins by O-GlcNAc. O-GlcNAc modifies thousa
Externí odkaz:
https://doaj.org/article/5a19690646294482b0ed8f21f1ec861d
Publikováno v:
Clinical and Translational Medicine, Vol 14, Iss 10, Pp n/a-n/a (2024)
Abstract Background The transcription factor NRF2 plays a significant role in regulating genes that protect cells from oxidative damage. O‐GlcNAc modification, a type of posttranslational modification, is crucial for cellular response to stress. Al
Externí odkaz:
https://doaj.org/article/615d85d315874a748ee852ac453a2ac3
Autor:
Liyuan Zhang, Tingzhi Deng, Shuijing Pan, Minghui Zhang, Yusen Zhang, Chunhua Yang, Xiaoyong Yang, Geng Tian, Jia Mi
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 12 (2024)
IntroductionProtein O-GlcNAcylation is a dynamic post-translational modification involved in major cellular processes and associated with many human diseases. Bioinformatic prediction of O-GlcNAc sites before experimental validation is a challenge ta
Externí odkaz:
https://doaj.org/article/60ce7a9d09dc4642843111cd520f4f45
Autor:
Rong Chen, Jiantao Hu, Yang Zhang, Yang Liu, Liujian Cao, Fan He, Qin Wang, Ying Chen, Shengwei Zhang, Songjiang Tang, Baojun Min
Publikováno v:
Brain Research Bulletin, Vol 217, Iss , Pp 111077- (2024)
Neuropathic pain results from damage to nerves or the brain, and is characterized by symptoms such as allodynia, spontaneous pain, and hyperalgesia. The causes of this type of pain are intricate, which can make it difficult to treat. Sodium aescinate
Externí odkaz:
https://doaj.org/article/63b8d649e6034699b394590da4dd0c42
Autor:
Ziteng Wang, Yu Ding, Pei Wang, Jinyan Yu, Shulun Huang, Lingjia Yang, Hongjing Gong, Zhen Yu, Rongguo Lu, Tao Bian, Yan Wu
Publikováno v:
Ecotoxicology and Environmental Safety, Vol 284, Iss , Pp 116931- (2024)
Cigarette smoke (CS) is a prevalent chemical indoor air contaminant known to be the primary cause of EMT during airway remodeling in COPD. While some evidence indicates the involvement of SMAD4 in EMT across certain diseases, its specific role in CS-
Externí odkaz:
https://doaj.org/article/78d7eecbad5a45fca48c5f7e190b9091