Zobrazeno 1 - 10
of 545
pro vyhledávání: '"nutlin-3"'
Autor:
Elisabetta Esposito, Francesca Ferrara, Markus Drechsler, Olga Bortolini, Daniele Ragno, Sofia Toldo, Agnese Bondi, Alessandra Pecorelli, Rebecca Voltan, Paola Secchiero, Giorgio Zauli, Giuseppe Valacchi
Publikováno v:
Life, Vol 14, Iss 1, p 155 (2024)
The skin’s protective mechanisms, in some cases, are not able to counteract the destructive effects induced by UV radiations, resulting in dermatological diseases, as well as skin aging. Nutlin-3, a potent drug with antiproliferative activity in ke
Externí odkaz:
https://doaj.org/article/1aaf7ad3cfba4eb9942379bc314ea470
Publikováno v:
BMC Medicine, Vol 20, Iss 1, Pp 1-17 (2022)
Abstract Background Fragile X syndrome (FXS), the most prevalent inherited intellectual disability and one of the most common monogenic forms of autism, is caused by a loss of fragile X messenger ribonucleoprotein 1 (FMR1). We have previously shown t
Externí odkaz:
https://doaj.org/article/49cda3c0fde74245aada0c716efb5fbd
Autor:
Giada Lodi, Valentina Gentili, Fabio Casciano, Arianna Romani, Giorgio Zauli, Paola Secchiero, Enrico Zauli, Carolina Simioni, Silvia Beltrami, Mercedes Fernandez, Roberta Rizzo, Rebecca Voltan
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
SARS-CoV viruses have been shown to downregulate cellular events that control antiviral defenses. They adopt several strategies to silence p53, key molecule for cell homeostasis and immune control, indicating that p53 has a central role in controllin
Externí odkaz:
https://doaj.org/article/aff01f04f79843be99423fa4621a001d
Autor:
Arianna Romani, Enrico Zauli, Giorgio Zauli, Saleh AlMesfer, Samar Al-Swailem, Rebecca Voltan
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
MDM2 is the principal inhibitor of p53, and MDM2 inhibitors can disrupt the physical interaction between MDM2 and p53. The half-life of p53 is very short in normal cells and tissues, and an uncontrolled increase in p53 levels has potential harmful ef
Externí odkaz:
https://doaj.org/article/9b20b8d0d4a645828c7598835c00b628
Publikováno v:
Frontiers in Medicine, Vol 9 (2022)
Starting from the beginning of the severe acute respiratory syndrome Coronavirus-2 (SARS-CoV-2) global pandemic, most of the published data has concentrated on the respiratory signs and symptoms of Covid-19 infection, underestimating the presence and
Externí odkaz:
https://doaj.org/article/cb0754ba7b534b9cbac2bc6df0f4682b
Autor:
Ruidong Li, Pavlina Zatloukalova, Petr Muller, Maria Gil-Mir, Sachin Kote, Simon Wilkinson, Alain J. Kemp, Lenka Hernychova, Yaxin Wang, Kathryn L. Ball, Kaixiong Tao, Ted Hupp, Borivoj Vojtesek
Publikováno v:
Cellular & Molecular Biology Letters, Vol 25, Iss 1, Pp 1-21 (2020)
Abstract Background The links between the p53/MDM2 pathway and the expression of pro-oncogenic immune inhibitory receptors in tumor cells are undefined. In this report, we evaluate whether there is p53 and/or MDM2 dependence in the expression of two
Externí odkaz:
https://doaj.org/article/b8f9b11009b24fcab0d358372577dfdf
Publikováno v:
BMC Cancer, Vol 20, Iss 1, Pp 1-14 (2020)
Abstract Background Despite an improvement of prognosis in breast and colon cancer, the outcome of the metastatic disease is still severe. Microevolution of cancer cells often leads to drug resistance and tumor-recurrence. To target the driving force
Externí odkaz:
https://doaj.org/article/7c0845de71254b40b3c7ee4204ae78bb
Akademický článek
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Publikováno v:
Cancer Cell International, Vol 19, Iss 1, Pp 1-15 (2019)
Abstract Background Emergence of resistance to molecular targeted therapy constitutes a limitation to clinical benefits in cancer treatment. Cross-resistance commonly happens with chemotherapeutic agents but might not with targeted agents. Methods In
Externí odkaz:
https://doaj.org/article/d52f6c520f674aa0ad3934c0311b3100
Akademický článek
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K zobrazení výsledku je třeba se přihlásit.
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