Zobrazeno 1 - 10
of 522
pro vyhledávání: '"nudt15"'
Publikováno v:
Acta Pharmaceutica, Vol 74, Iss 3, Pp 355-381 (2024)
Despite great therapeutic advances in the field of biologics, small synthetic molecules such as thiopurines, including azathioprine, mercaptopurine, and thioguanine, remain an important therapeutic pillar in the treatment of inflammatory bowel diseas
Externí odkaz:
https://doaj.org/article/dc46147608ac49e483c3a232907cf544
Autor:
Priyanga Ranasinghe, Nirmala Sirisena, Thuwaragesh Vishnukanthan, J. N. Ariadurai, Sathsarani Thilakarathne, C. D. Nelanka Priyadarshani, D. P. Bhagya Hendalage, Vajira H. W. Dissanayake
Publikováno v:
BMC Medical Genomics, Vol 17, Iss 1, Pp 1-9 (2024)
Abstract Background Therapy with anti-cancer drugs remain the cornerstone of treating cancer. The effectiveness and safety of anti-cancer drugs vary significantly among individuals due to genetic factors influencing the drug response and metabolism.
Externí odkaz:
https://doaj.org/article/279e894234f64531bcf8cbe8cf81a772
Autor:
Duong Bich Tram, Ho Quoc Chuong, Huynh Anh Phuong, Nguyen The Nguyen Phung, Mai-Lan Nguyen, Hoang Anh Vu
Publikováno v:
Journal of Laboratory Physicians, Vol 15, Iss 04, Pp 567-572 (2023)
Objective The NUDT15 variants impact thiopurine dose selection in acute lymphoblastic leukemia patients. The ability to rapidly detect variants is important in clinical practice. This study aims to develop a simple polymerase chain reaction (PCR) pro
Externí odkaz:
https://doaj.org/article/a6578879660648f3b479227d51b244ed
Publikováno v:
Frontiers in Oncology, Vol 14 (2024)
IntroductionPolymorphisms in NUDT15 may result in differences in mercaptopurine-induced toxicity. This study aimed to identify the frequency of the NUDT15 (c.415C>T; rs116855232) polymorphism and investigate the effect of this polymorphism on mercapt
Externí odkaz:
https://doaj.org/article/5f79fb77ffb04e4aac846e4dfb5f426c
Autor:
Yoichi Kakuta, Motohiro Kato, Yusuke Shimoyama, Takeo Naito, Rintaro Moroi, Masatake Kuroha, Hisashi Shiga, Yoshitaka Kinouchi, Atsushi Masamune
Publikováno v:
Journal of Pharmacological Sciences, Vol 153, Iss 3, Pp 161-169 (2023)
The usefulness of NUDT15 genotyping as a pharmacogenomic test for thiopurine has been established. The first such test developed to date, NUDT15 genotyping was approved for reimbursement in Japan in February 2019 for all indicated patients. We retros
Externí odkaz:
https://doaj.org/article/f0a387ae9651457ab87e912b9f263c72
Autor:
Janakiraman V., Sudhan M., Khalaf F. Alsharif, Ibrahim F. Halawani, Shiek S. S. J. Ahmed, Shankargouda Patil
Publikováno v:
Journal of Genetic Engineering and Biotechnology, Vol 21, Iss 1, Pp 1-11 (2023)
Abstract Background Human nucleotide triphosphate diphosphatase (NUDT15) is one of the essential proteins involved in the hydrolysis of anti-cancer drugs against leukemia. Polymorphisms in NUDT15 significantly affect the hydrolysis activity that lead
Externí odkaz:
https://doaj.org/article/c6e76aaefce645a7807b1da000cd3b52
Autor:
Shizuka Suzuki, Kan Uchiyama, Yutaro Motoi, Yuuki Yoshii, Yukari Inoue, Takahiro Kubota, Shunichi Odahara, Yuichiro Ohtaki, Shinichiro Takami, Zensho Ito, Nobuhiro Sato, Toshifumi Ohkusa, Shigeo Koido, Masayuki Saruta
Publikováno v:
BMC Gastroenterology, Vol 23, Iss 1, Pp 1-11 (2023)
Abstract Background Thiopurines continue to play an important role in the treatment of inflammatory bowel disease (IBD). It is well known that thiopurines can cause several adverse reactions. Especially, hematopoietic toxicity may lead to severe agra
Externí odkaz:
https://doaj.org/article/5ef338f38413497daa6f52c09275bbff
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
This is the first report of the distribution of TPMT and NUDT15 single nucleotide polymorphisms and metabolic phenotypes associated with cytotoxicity of thiopurine drugs, in indigenous groups of Brazilian Amazon: Munduruku, Paiter-Suruí and Yanomami
Externí odkaz:
https://doaj.org/article/528fbf49a0a1465683347074b5cc13ef
Autor:
Xando Díaz-Villamarín, Emilio Fernández-Varón, Michelle Carolina Rojas Romero, José Luis Callejas-Rubio, José Cabeza-Barrera, Alba Rodríguez-Nogales, Julio Gálvez, Rocío Morón
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 168, Iss , Pp 115706- (2023)
Azathioprine is commonly used as an immunosuppressive antimetabolite in the treatment of acute lymphoblastic leukemia, autoimmune disorders (such as Crohn's disease and rheumatoid arthritis), and in patients receiving organ transplants. Thiopurine-S-
Externí odkaz:
https://doaj.org/article/129b5c0278254f8992f2b564483619e5
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