Zobrazeno 1 - 10
of 3 687
pro vyhledávání: '"nucleoside analogs"'
Publikováno v:
Organics, Vol 5, Iss 2, Pp 71-110 (2024)
Nucleoside analogs (NAs) have been extensively examined as plausible antiviral agents in recent years, in particular since the outbreak of the global pandemic of COVID-19 in 2019. In this review, the structures and antiviral properties of over 450 NA
Externí odkaz:
https://doaj.org/article/c3e3249590654dbaa0b3eb548d56cb19
Autor:
Daniel Hormigo, Jon Del Arco, Javier Acosta, Maximilian J. L. J. Fürst, Jesús Fernández-Lucas
Publikováno v:
Biomolecules, Vol 14, Iss 9, p 1196 (2024)
Nucleoside phosphorylases (NPs) are pivotal enzymes in the salvage pathway, catalyzing the reversible phosphorolysis of nucleosides to produce nucleobases and α-D-ribose 1-phosphate. Due to their efficiency in catalyzing nucleoside synthesis from pu
Externí odkaz:
https://doaj.org/article/771d1b52199b4dc0b69074b229b70371
Publikováno v:
Small Structures, Vol 5, Iss 4, Pp n/a-n/a (2024)
Two convergent approaches for synthesizing a new class of nucleoside diphosphate prodrugs bearing different nucleoside analogs are reported herein. The DiPPro‐nucleotides comprise an acyloxybenzyl group in combination with a lipophilic alkyl residu
Externí odkaz:
https://doaj.org/article/cd4af696484a442d899ea412d318bbb6
Publikováno v:
BMC Infectious Diseases, Vol 23, Iss 1, Pp 1-15 (2023)
Abstract Objective To compare the effectiveness of seven major interventions [Bulevirtide (BLV), Interferon (IFN), Nucleoside analogs (NAs), BLV + IFN, BLV + NAs, IFN + NAs, and Placebo] to treat chronic hepatitis D. Methods We followed PRISMA-NMA gu
Externí odkaz:
https://doaj.org/article/d531aa1b4cef4809857f5760118ff7b5
Autor:
Elena Pérez, Javier Acosta, Victor Pisabarro, Marco Cordani, José C. S. dos Santos, Jon Sanz-Landaluze, Juan Gallo, Manuel Bañobre-López, Jesús Fernández-Lucas
Publikováno v:
Biomolecules, Vol 14, Iss 8, p 894 (2024)
Directed enzyme prodrug therapy (DEPT) strategies show promise in mitigating chemotherapy side effects during cancer treatment. Among these, the use of immobilized enzymes on solid matrices as prodrug activating agents (IDEPT) presents a compelling d
Externí odkaz:
https://doaj.org/article/f851e75f62374e88805f6d7d4bdf9688
Autor:
Elena Marchesi, Elisabetta Melloni, Fabio Casciano, Elena Pozza, Roberto Argazzi, Carmela De Risi, Lorenzo Preti, Daniela Perrone, Maria Luisa Navacchia
Publikováno v:
Molecules, Vol 29, Iss 14, p 3383 (2024)
Herein, we report the synthesis of a new hybrid compound based on a 2′-deoxyuridine nucleoside conjugated with a NO photo-donor moiety (dU-t-NO) via CuAAC click chemistry. Hybrid dU-t-NO, as well as two previously reported 2′-deoxyadenosine based
Externí odkaz:
https://doaj.org/article/304fe710d7984b7f8c515a743a68d86f
Publikováno v:
Biomolecules, Vol 14, Iss 6, p 701 (2024)
Chemo-enzymatic syntheses of strongly fluorescent nucleoside analogs, potentially applicable in analytical biochemistry and cell biology are reviewed. The syntheses and properties of fluorescent ribofuranosides of several purine, 8-azapurine, and eth
Externí odkaz:
https://doaj.org/article/a4dd4b9657384224976c9ca8b71ea443
Autor:
Zongqi Shi, Huizhi Zheng, Miaomiao Han, Jieli Hu, Yuan Hu, Xiaosong Li, Wenyan Zhu, Xinjun He, Haijun Deng, Quanxin Long, Ailong Huang
Publikováno v:
Genes and Diseases, Vol 10, Iss 3, Pp 1019-1028 (2023)
Little is known about the difference in durability of HBsAg seroclearance induced by nucleoside analogs (NAs) or by interferon (IFN). A real-world, retrospective cohort study was conducted. Patients were assigned into two groups: NAs monotherapy-indu
Externí odkaz:
https://doaj.org/article/5d3d6c25bf4e458688f9d95f84516ce6
Autor:
Oleg V. Maltsev, Kristina V. Kasyanenko, Konstantin V. Zhdanov, Nikolay A. Malyshev, Elena V. Kolomoets, Victor K. Konomou
Publikováno v:
Терапевтический архив, Vol 95, Iss 1, Pp 85-89 (2023)
Dengue fever is classified as one of the most common viral diseases with a transmission mechanism implemented through arthropod vectors. The expansion of of the Aedes aegypti mosquito is leading to a significant increase in the number of cases of den
Externí odkaz:
https://doaj.org/article/af4b6ea3f0dc4afaba1a66419555509c
Publikováno v:
Тонкие химические технологии, Vol 17, Iss 4, Pp 311-322 (2022)
Objectives. A key step in the synthesis of natural nucleoside analogs is the formation of a glycosidic bond between the carbohydrate fragment and the heterocyclic base. Glycosylation methods differ in terms of regio- and stereoselectivity. A promisin
Externí odkaz:
https://doaj.org/article/5955fd175ddb48e6a88e8459c8296d11