Zobrazeno 1 - 10
of 563
pro vyhledávání: '"nucleocytoplasmic shuttling"'
Publikováno v:
Discover Oncology, Vol 15, Iss 1, Pp 1-17 (2024)
Abstract Protein shuttling between the cytoplasm and nucleus is a unique phenomenon in eukaryotic organisms, integral to various cellular functions. Membrane-bound transcription factors (MTFs), a specialized class of nucleocytoplasmic shuttling prote
Externí odkaz:
https://doaj.org/article/cbc7b9faeac84515870f0a6370aeacd6
Publikováno v:
Nucleus, Vol 15, Iss 1 (2024)
ABSTRACTThe view on nuclear filaments formed by non-skeletal β-actin has significantly changed over the decades. Initially, filamentous actin was observed in amphibian oocyte nuclei and only under specific cell stress conditions in mammalian cell nu
Externí odkaz:
https://doaj.org/article/8b427a43d7e342b48abca34eeb444742
Publikováno v:
Cells, Vol 13, Iss 15, p 1266 (2024)
Nucleophosmin (NPM1) is a key nucleolar protein released from the nucleolus in response to stress stimuli. NPM1 functions as a stress regulator with nucleic acid and protein chaperone activities, rapidly shuttling between the nucleus and cytoplasm. N
Externí odkaz:
https://doaj.org/article/ea20f386f090454b962713a5600c95b0
Publikováno v:
Virulence, Vol 14, Iss 1 (2023)
ABSTRACTHeterogeneous nuclear ribonucleoprotein A1 (hnRNPA1) plays an important role in regulating the replication of many viruses. However, it remains elusive whether and how hnRNPA1 regulates fish virus replication. In this study, the effects of tw
Externí odkaz:
https://doaj.org/article/72212d3bdb4b4a608ad34f93fa6da0e6
Autor:
Fedon-Giasin Kattan, Pelagia Koukouraki, Athanasios K. Anagnostopoulos, George T. Tsangaris, Epaminondas Doxakis
Publikováno v:
Open Biology, Vol 13, Iss 11 (2023)
Alpha-synuclein (SNCA) accumulation plays a central role in the pathogenesis of Parkinson's disease. Determining and interfering with the mechanisms that control SNCA expression is one approach to limiting disease progression. Currently, most of our
Externí odkaz:
https://doaj.org/article/2c0ff17f11e44f029773101018ac9f94
Autor:
Shuang Cui, Huijian Hu, An Chen, Ming Cui, Xiaojie Pan, Pengfei Zhang, Guangji Wang, Hong Wang, Haiping Hao
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 13, Iss 2, Pp 559-576 (2023)
Farnesoid X receptor (FXR) is widely accepted as a promising target for various liver diseases; however, panels of ligands in drug development show limited clinical benefits, without a clear mechanism. Here, we reveal that acetylation initiates and o
Externí odkaz:
https://doaj.org/article/3a438e06210740cc88df6677d576db3b
Autor:
Yaw-Dong Lang, Yuh-Shan Jou
Publikováno v:
Journal of Biomedical Science, Vol 28, Iss 1, Pp 1-12 (2021)
Abstract Dysregulation of nucleocytoplasmic shuttling is commonly observed in cancers and emerging as a cancer hallmark for the development of anticancer therapeutic strategies. Despite its severe adverse effects, selinexor, a selective first-in-clas
Externí odkaz:
https://doaj.org/article/d77aeb2461774c6e89adfd0fccfa2f53
Autor:
Zhanwu Zhu, Jingjing Liu, Huan Feng, Yanning Zhang, Ruiqi Huang, Qiaochu Pan, Jing Nan, Ruidong Miao, Bo Cheng
Publikováno v:
eLife, Vol 11 (2022)
Dynamic regulation of transcription is crucial for the cellular responses to various environmental or developmental cues. Gdown1 is a ubiquitously expressed, RNA polymerase II (Pol II) interacting protein, essential for the embryonic development of m
Externí odkaz:
https://doaj.org/article/ec764ce002d24088ba8e53790053d0a2
Autor:
Zahra Safaei, Gary L. Thompson
Publikováno v:
Frontiers in Bioengineering and Biotechnology, Vol 10 (2022)
Electroporation-based technologies using microsecond pulsed electric field (µsPEF) exposures are established as laboratory and clinical tools that permeabilize cell membranes. We demonstrate a µsPEF bioeffect on nucleocytoplasmic import and export
Externí odkaz:
https://doaj.org/article/e55c8c653a294dc8b9f36165f577d646
Autor:
Laura Lafon-Hughes
Publikováno v:
Pathogens, Vol 12, Iss 6, p 806 (2023)
Despite what its name suggests, the effects of the COVID-19 pandemic causative agent “Severe Acute Respiratory Syndrome Coronavirus-2” (SARS-CoV-2) were not always confined, neither temporarily (being long-term rather than acute, referred to as L
Externí odkaz:
https://doaj.org/article/a6681a72303944eca3d26753a8d574af