Zobrazeno 1 - 10
of 41
pro vyhledávání: '"nuclear receptor-related 1"'
The Role of TrkB and BDNF Signaling Pathways in Autism Spectrum Disorder: Insights from Mouse Models
Autor:
Abdollahi, Mona
This research delves into idiopathic autism spectrum disorder (ASD), investigating the role of TrkB signaling pathways and BDNF regulation in the cortex. Additionally, it explores offering insights into maternal influences on mouse models.
Autis
Autis
Externí odkaz:
http://hdl.handle.net/11375/29724
Autor:
Congcong Jia, Hongqian Qi, Cheng Cheng, Xuefei Wu, Zhaofei Yang, Huaibin Cai, Sheng Chen, Weidong Le
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 13 (2020)
The nuclear receptor-related 1 protein (Nurr1) is critical for the development and survival of midbrain dopamine neurons that are predominantly affected and progressively degenerated in Parkinson’s disease (PD). The expression level of Nurr1 has be
Externí odkaz:
https://doaj.org/article/d5cf9060c2aa470aa4d12d404a22ee7b
Publikováno v:
International Journal of Molecular Sciences, Vol 20, Iss 19, p 4858 (2019)
The transcription factor NURR1 is a constitutively active orphan receptor belonging to the steroid hormone receptor class NR4A. Although a genetic association between NURR1 and autoimmune inflammatory diseases has never emerged from genome-wide assoc
Externí odkaz:
https://doaj.org/article/630de27b650842b796758912117627ee
Publikováno v:
International Journal of Molecular Sciences; Volume 23; Issue 5; Pages: 2900
Neonatal hypoxic–ischemic encephalopathy (HIE) results in neurological impairments; cell-based therapy has been suggested as a therapeutic avenue. Previous research has demonstrated the synergistically potentiated therapeutic efficacy of human umbi
Publikováno v:
ChemMedChem. 17(8)
Several lines of evidence suggest the ligand-sensing transcription factor Nurr1 as a promising target to treat neurodegenerative diseases. Nurr1 modulators to validate and exploit this therapeutic potential are rare, however. To identify novel Nurr1
Autor:
Choong Hyun Lee, Young-Eun Park, Joon Ha Park, Jae-Chul Lee, Ji Hyeon Ahn, Moo Ho Won, Go Eun Yang, Tae‑Kyeong Lee, Cheolwoo Park, Dae Won Kim, Hyang Ah Lee
Publikováno v:
Molecular Medicine Reports
Nuclear receptor related 1 protein (Nurr1), a member of the nuclear receptor 4 family of orphan nuclear receptors, has been reported to display anti‑inflammatory properties. The present study investigated the alteration of Nurr1 immunoreactivity in
Autor:
Yu Zhang, Shouichi Ohga, Yasunari Sakai, Yuta Hirofuji, Takahiro A. Kato, Xiao Sun, Hiroki Kato, Satoshi Fukumoto, Michiko Torio, Xu Han, Hiroshi Sato, Keiji Masuda
Publikováno v:
Biochemistry and Biophysics Reports, Vol 26, Iss, Pp 100968-(2021)
Biochemistry and Biophysics Reports
Biochemistry and Biophysics Reports
Transient receptor potential vanilloid member 4 (TRPV4) is a Ca2+ permeable nonselective cation channel, and mutations in the TRPV4 gene cause congenital skeletal dysplasias and peripheral neuropathies. Although TRPV4 is widely expressed in the brain
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