Zobrazeno 1 - 10 of 77 pro vyhledávání: '"nuclear localisation signal"'
1
Akademický článek
Engineering of Chinese Hamster Ovary Cells With NDPK-A to Enhance DNA Nuclear Delivery Combined With EBNA1 Plasmid Maintenance Gives Improved Exogenous Transient Reporter, mAb and SARS-CoV-2 Spike Protein Expression
Autor: James D. Budge, Robert J. Young, Christopher Mark Smales
Publikováno v: Frontiers in Bioengineering and Biotechnology, Vol 9 (2021)
Transient gene expression (TGE) in mammalian cells is a method of rapidly generating recombinant protein material for initial characterisation studies that does not require time-consuming processes associated with stable cell line construction. High
Externí odkaz: https://doaj.org/article/598c0e396713447c9ad8bc844e3d0ca6
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2
Akademický článek
Modulation of Early Host Innate Immune Response by an Avipox Vaccine Virus’ Lateral Body Protein
Autor: Efstathios S. Giotis, Stephen M. Laidlaw, Susanna R. Bidgood, David Albrecht, Jemima J. Burden, Rebecca C. Robey, Jason Mercer, Michael A. Skinner
Publikováno v: Biomedicines, Vol 8, Iss 12, p 634 (2020)
The avian pathogen fowlpox virus (FWPV) has been successfully used as a vaccine vector in poultry and humans, but relatively little is known about its ability to modulate host antiviral immune responses in these hosts, which are replication-permissiv
Externí odkaz: https://doaj.org/article/bcd2342d2df34c9faf16cfb083aaf866
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3
Engineering of Chinese Hamster Ovary Cells With NDPK-A to Enhance DNA Nuclear Delivery Combined With EBNA1 Plasmid Maintenance Gives Improved Exogenous Transient Reporter, mAb and SARS-CoV-2 Spike Protein Expression
Autor: Christopher Mark Smales, Robert J. Young, James D. Budge
Publikováno v: Frontiers in Bioengineering and Biotechnology
Frontiers in Bioengineering and Biotechnology, Vol 9 (2021)
Transient gene expression (TGE) in mammalian cells is a method of rapidly generating recombinant protein material for initial characterisation studies that does not require time-consuming processes associated with stable cell line construction. High
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41b90bd8f506f49d5173a71df5421ea6
https://doi.org/10.3389/fbioe.2021.679448
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4
Modulation of Early Host Innate Immune Response by an Avipox Vaccine Virus’ Lateral Body Protein
Autor: Jemima J. Burden, David Albrecht, Michael A. Skinner, Efstathios S. Giotis, Rebecca C. Robey, Stephen M. Laidlaw, Jason Mercer, Susanna R. Bidgood
Publikováno v: Biomedicines, Vol 8, Iss 634, p 634 (2020)
Biomedicines
Volume 8
Issue 12
The avian pathogen fowlpox virus (FWPV) has been successfully used as a vaccine vector in poultry and humans, but relatively little is known about its ability to modulate host antiviral immune responses in these hosts, which are replication-permissiv
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09ea0953196337a55993d9a5b286cb86
https://www.mdpi.com/2227-9059/8/12/634
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6
Adenovirus Terminal Protein Contains a Bipartite Nuclear Localisation Signal Essential for Its Import into the Nucleus
Autor: David R. Thomas, Hareth Al-Wassiti, Kylie M. Wagstaff, Colin W. Pouton, Angus P. R. Johnston, David A. Jans, Stewart A. Fabb
Publikováno v: International Journal of Molecular Sciences
Volume 22
Issue 7
International Journal of Molecular Sciences, Vol 22, Iss 3310, p 3310 (2021)
Adenoviruses contain dsDNA covalently linked to a terminal protein (TP) at the 5′end. TP plays a pivotal role in replication and long-lasting infectivity. TP has been reported to contain a nuclear localisation signal (NLS) that facilitates its impo
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0e270667aa23e631bc2afc373796eca
https://doi.org/10.3390/ijms22073310
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7
Akademický článek
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8
Structural and calorimetric studies demonstrate that the hepatocyte nuclear factor 1β (HNF1β) transcription factor is imported into the nucleus via a monopartite NLS sequence
Autor: Mareike M. Wiedmann, Murray Stewart, Shintaro Aibara, James D. Brenton, David R. Spring
Publikováno v: Journal of Structural Biology
The transcription factor hepatocyte nuclear factor 1β (HNF1β) is ubiquitously overexpressed in ovarian clear cell carcinoma (CCC) and is a potential therapeutic target. To explore potential approaches that block HNF1β transcription we have identif
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07cdc136a8a8b67b570e14b2d6984d3f
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9
Akademický článek
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10
The physiological and pathological biophysics of phase separation and gelation of RNA binding proteins in amyotrophic lateral sclerosis and fronto-temporal lobar degeneration
Autor: Peter, St George-Hyslop, Julie Qiaojin, Lin, Akinori, Miyashita, Emma C, Phillips, Seema, Qamar, Suzanne J, Randle, GuoZhen, Wang
Publikováno v: Brain Research
Graphical abstract
Highlights • Some intrinsically disordered proteins undergo reversible phase separation/gelation. • Reversible phase separation/gelation underpins function of membraneless organelles. • fALS-FUS mutations increase propen
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::d7c33cdb5ca19f9cf1f4a371dcd4e851
https://pubmed.ncbi.nlm.nih.gov/29723523
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