Zobrazeno 1 - 10
of 4 403
pro vyhledávání: '"nuclear import"'
Autor:
James McGehee, Angelike Stathopoulos
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 12 (2024)
Formation of the Dorsal nuclear-cytoplasmic gradient is important for the proper establishment of gene expression patterns along the dorsal-ventral (DV) axis during embryogenesis in Drosophila melanogaster. Correct patterning of the DV axis leads to
Externí odkaz:
https://doaj.org/article/1c2a3446d947451baae07c70e252ed60
Publikováno v:
Cancer Communications, Vol 44, Iss 3, Pp 361-383 (2024)
Abstract Background Lymphatic metastasis is one of the most common metastatic routes and indicates a poor prognosis in clear‐cell renal cell carcinoma (ccRCC). N‐acetyltransferase 10 (NAT10) is known to catalyze N4‐acetylcytidine (ac4C) modific
Externí odkaz:
https://doaj.org/article/e67f27c75b7149188ac9205b8488b3a6
Autor:
Xueyun Li, Tingting Jia, Kele Wang, Liangliang Wang, Lijuan Zhou, Mao Li, Wenfei Zhu, Yuelong Shu, Yongkun Chen
Publikováno v:
Emerging Microbes and Infections, Vol 13, Iss 1 (2024)
Avian influenza viruses (AIVs) are the origin of multiple mammal influenza viruses. The genetic determinants of AIVs adapted to humans have been widely elucidated, however, the molecular mechanism of cross-species transmission and adaptation of AIVs
Externí odkaz:
https://doaj.org/article/3e822c84b96c443e96bb8323290fe6f2
Autor:
Zhuogang Li, Yuanyuan Duan, Yang Yu, Yue Su, Mingxin Zhang, Yarou Gao, Lefang Jiang, Haonan Zhang, Xiaoqin Lian, Xingjian Zhu, Jiaxin Ke, Qun Peng, Xulin Chen
Publikováno v:
Microorganisms, Vol 12, Iss 5, p 1017 (2024)
Both pandemic and seasonal influenza are major health concerns, causing significant mortality and morbidity. Current influenza drugs primarily target viral neuraminidase and RNA polymerase, which are prone to drug resistance. Polyoxometalates (POMs)
Externí odkaz:
https://doaj.org/article/77467abc27694affb4cbc1f5bf158103
Autor:
Kun Zhao, Dongxu Hua, Chuanxi Yang, Xiaoguang Wu, Yukang Mao, Yanhui Sheng, Wei Sun, Yong Li, Xiangqing Kong, Peng Li
Publikováno v:
Cell Communication and Signaling, Vol 21, Iss 1, Pp 1-19 (2023)
Abstract Alamandine (Ala), a ligand of Mas-related G protein-coupled receptor, member D (MrgD), alleviates angiotensin II (AngII)-induced cardiac hypertrophy. However, the specific physiological and pathological role of MrgD is not yet elucidated. He
Externí odkaz:
https://doaj.org/article/58400c50dddd419c908632de8fde5a61
Autor:
Wenjun Shi, Zhibo Shan, Li Jiang, Guangwen Wang, Xuyuan Wang, Yu Chang, Yuzhen Hu, Bo Wang, Qibing Li, Yihan Wang, Guohua Deng, Jianzhong Shi, Yongping Jiang, Xianying Zeng, Guobin Tian, Hualan Chen, Chengjun Li
Publikováno v:
Emerging Microbes and Infections, Vol 12, Iss 2 (2023)
Influenza A viruses (IAVs) continue to cause tremendous economic losses to the global animal industry and respiratory diseases and deaths among humans. The nuclear import of the vRNP complex, composed of polymerase basic protein 1 (PB1), polymerase b
Externí odkaz:
https://doaj.org/article/89fdf13545734e07b4134428535565aa
Autor:
Katharina S. Keuenhof, Verena Kohler, Filomena Broeskamp, Dimitra Panagaki, Sean D. Speese, Sabrina Büttner, Johanna L. Höög
Publikováno v:
Nucleus, Vol 14, Iss 1 (2023)
ABSTRACTThe nuclear pore complex (NPC) has long been assumed to be the sole route across the nuclear envelope, and under normal homeostatic conditions it is indeed the main mechanism of nucleo-cytoplasmic transport. However, it has also been known th
Externí odkaz:
https://doaj.org/article/4b7bb68c77f04a0bb213452995631ac2
Autor:
Maria Körner, Susanne R Meyer, Gabriella Marincola, Maximilian J Kern, Clemens Grimm, Christina Schuelein-Voelk, Utz Fischer, Kay Hofmann, Alexander Buchberger
Publikováno v:
eLife, Vol 12 (2023)
The ATPase p97 (also known as VCP, Cdc48) has crucial functions in a variety of important cellular processes such as protein quality control, organellar homeostasis, and DNA damage repair, and its de-regulation is linked to neuromuscular diseases and
Externí odkaz:
https://doaj.org/article/088885aee7b845c49c72985154a87b7b
Autor:
Mariangela Succoio, Sara Amiranda, Emanuele Sasso, Carmen Marciano, Arianna Finizio, Giuseppina De Simone, Corrado Garbi, Nicola Zambrano
Publikováno v:
Heliyon, Vol 9, Iss 8, Pp e18885- (2023)
The human carbonic anhydrase IX (CA IX) is a hypoxia-induced transmembrane protein belonging to the α-CA enzyme family. It has a crucial role in pH regulation in hypoxic cells and acts by buffering intracellular acidosis induced by hypoxia. Indeed,
Externí odkaz:
https://doaj.org/article/a17f2137ad6844cfbf172125c79239b4
Publikováno v:
Plants, Vol 13, Iss 2, p 279 (2024)
The mechanical damage of plant tissues leads to the activation of methanol production and its release into the atmosphere. The gaseous methanol or vapors emitted by the damaged plant induce resistance in neighboring intact plants to bacterial pathoge
Externí odkaz:
https://doaj.org/article/f3897347c76749b6a41278f70858e2a4