Zobrazeno 1 - 10
of 4 404
pro vyhledávání: '"nuclear import"'
Autor:
Aude Boulay, Emmanuel Quevarec, Isabelle Malet, Giuseppe Nicastro, Célia Chamontin, Suzon Perrin, Corinne Henriquet, Martine Pugnière, Valérie Courgnaud, Mickaël Blaise, Anne-Geneviève Marcelin, Ian A Taylor, Laurent Chaloin, Nathalie J Arhel
Publikováno v:
EMBO Molecular Medicine, Vol 16, Iss 11, Pp 2918-2945 (2024)
Abstract HIV-1 capsids cross nuclear pore complexes (NPCs) by engaging with the nuclear import machinery. To identify compounds that inhibit HIV-1 nuclear import, we screened drugs in silico on a three-dimensional model of a CA hexamer bound by Trans
Externí odkaz:
https://doaj.org/article/7cbc18f74cf040398f77493b6d8d2daf
Publikováno v:
Cancer Communications, Vol 44, Iss 3, Pp 361-383 (2024)
Abstract Background Lymphatic metastasis is one of the most common metastatic routes and indicates a poor prognosis in clear‐cell renal cell carcinoma (ccRCC). N‐acetyltransferase 10 (NAT10) is known to catalyze N4‐acetylcytidine (ac4C) modific
Externí odkaz:
https://doaj.org/article/e67f27c75b7149188ac9205b8488b3a6
Autor:
Xueyun Li, Tingting Jia, Kele Wang, Liangliang Wang, Lijuan Zhou, Mao Li, Wenfei Zhu, Yuelong Shu, Yongkun Chen
Publikováno v:
Emerging Microbes and Infections, Vol 13, Iss 1 (2024)
Avian influenza viruses (AIVs) are the origin of multiple mammal influenza viruses. The genetic determinants of AIVs adapted to humans have been widely elucidated, however, the molecular mechanism of cross-species transmission and adaptation of AIVs
Externí odkaz:
https://doaj.org/article/3e822c84b96c443e96bb8323290fe6f2
Autor:
James McGehee, Angelike Stathopoulos
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 12 (2024)
Formation of the Dorsal nuclear-cytoplasmic gradient is important for the proper establishment of gene expression patterns along the dorsal-ventral (DV) axis during embryogenesis in Drosophila melanogaster. Correct patterning of the DV axis leads to
Externí odkaz:
https://doaj.org/article/1c2a3446d947451baae07c70e252ed60
Autor:
Annett Petrich, Gyu Min Hwang, Laetitia La Rocca, Mariam Hassan, Maria Anders-Össwein, Vera Sonntag-Buck, Anke-Mareil Heuser, Vibor Laketa, Barbara Müller, Hans-Georg Kräusslich, Severina Klaus
Publikováno v:
Viruses, Vol 16, Iss 10, p 1610 (2024)
Expansion microscopy has recently emerged as an alternative technique for achieving high-resolution imaging of biological structures. Improvements in resolution are achieved by physically expanding samples through embedding in a swellable hydrogel be
Externí odkaz:
https://doaj.org/article/f02c8a13f8814d75a9e1d204989e6398
Autor:
Kun Zhao, Dongxu Hua, Chuanxi Yang, Xiaoguang Wu, Yukang Mao, Yanhui Sheng, Wei Sun, Yong Li, Xiangqing Kong, Peng Li
Publikováno v:
Cell Communication and Signaling, Vol 21, Iss 1, Pp 1-19 (2023)
Abstract Alamandine (Ala), a ligand of Mas-related G protein-coupled receptor, member D (MrgD), alleviates angiotensin II (AngII)-induced cardiac hypertrophy. However, the specific physiological and pathological role of MrgD is not yet elucidated. He
Externí odkaz:
https://doaj.org/article/58400c50dddd419c908632de8fde5a61
Autor:
Wenjun Shi, Zhibo Shan, Li Jiang, Guangwen Wang, Xuyuan Wang, Yu Chang, Yuzhen Hu, Bo Wang, Qibing Li, Yihan Wang, Guohua Deng, Jianzhong Shi, Yongping Jiang, Xianying Zeng, Guobin Tian, Hualan Chen, Chengjun Li
Publikováno v:
Emerging Microbes and Infections, Vol 12, Iss 2 (2023)
Influenza A viruses (IAVs) continue to cause tremendous economic losses to the global animal industry and respiratory diseases and deaths among humans. The nuclear import of the vRNP complex, composed of polymerase basic protein 1 (PB1), polymerase b
Externí odkaz:
https://doaj.org/article/89fdf13545734e07b4134428535565aa
Autor:
Katharina S. Keuenhof, Verena Kohler, Filomena Broeskamp, Dimitra Panagaki, Sean D. Speese, Sabrina Büttner, Johanna L. Höög
Publikováno v:
Nucleus, Vol 14, Iss 1 (2023)
ABSTRACTThe nuclear pore complex (NPC) has long been assumed to be the sole route across the nuclear envelope, and under normal homeostatic conditions it is indeed the main mechanism of nucleo-cytoplasmic transport. However, it has also been known th
Externí odkaz:
https://doaj.org/article/4b7bb68c77f04a0bb213452995631ac2
Autor:
Zhuogang Li, Yuanyuan Duan, Yang Yu, Yue Su, Mingxin Zhang, Yarou Gao, Lefang Jiang, Haonan Zhang, Xiaoqin Lian, Xingjian Zhu, Jiaxin Ke, Qun Peng, Xulin Chen
Publikováno v:
Microorganisms, Vol 12, Iss 5, p 1017 (2024)
Both pandemic and seasonal influenza are major health concerns, causing significant mortality and morbidity. Current influenza drugs primarily target viral neuraminidase and RNA polymerase, which are prone to drug resistance. Polyoxometalates (POMs)
Externí odkaz:
https://doaj.org/article/77467abc27694affb4cbc1f5bf158103
Autor:
Maria Körner, Susanne R Meyer, Gabriella Marincola, Maximilian J Kern, Clemens Grimm, Christina Schuelein-Voelk, Utz Fischer, Kay Hofmann, Alexander Buchberger
Publikováno v:
eLife, Vol 12 (2023)
The ATPase p97 (also known as VCP, Cdc48) has crucial functions in a variety of important cellular processes such as protein quality control, organellar homeostasis, and DNA damage repair, and its de-regulation is linked to neuromuscular diseases and
Externí odkaz:
https://doaj.org/article/088885aee7b845c49c72985154a87b7b