Zobrazeno 1 - 10
of 655
pro vyhledávání: '"nuclear factor erythroid 2-related factor 2 (nrf2)"'
Autor:
Caterina Saija, Monica Currò, Salvatore Arena, Maria Paola Bertuccio, Fabiola Cassaro, Angela Simona Montalto, Michele Rosario Colonna, Daniela Caccamo, Carmelo Romeo, Pietro Impellizzeri
Publikováno v:
Current Issues in Molecular Biology, Vol 46, Iss 9, Pp 9401-9414 (2024)
Lichen sclerosus (LS) is a chronic inflammatory disease of the skin, and the gold standard for treatment is the use of the very potent topical steroids, but they can have side effects. Previously, we demonstrated that OZOILE (stable ozonides) were ef
Externí odkaz:
https://doaj.org/article/0e3a8de3081e4a96856a99e98d5da0e6
Autor:
Xiaohui Kong, Mingyan Wang, Zhiheng Guo, Xingda Yang, Hongxia Lian, Tengyun Gao, Liyang Zhang, Tong Fu
Publikováno v:
Frontiers in Veterinary Science, Vol 11 (2024)
Mastitis is one of the most common diseases in dairy farms. During the perinatal period, the bovine mammary epithelial cells (BMECs) of High-yielding dairy cows accelerate metabolism and produce large amounts of reactive oxygen species (ROS). It is o
Externí odkaz:
https://doaj.org/article/04990603fe6342689b022f091c343e93
Autor:
Adeyemi Fatai Odetayo, Roland Eghoghosoa Akhigbe, Moses Agbomhere Hamed, Morufu Eyitayo Balogun, David Tolulope Oluwole, Luqman Aribidesi Olayaki
Publikováno v:
Frontiers in Nutrition, Vol 11 (2024)
BackgroundTamoxifen (TAM) is a widely used drug in patients with gynecomastia and breast cancer. TAM exerts its anticancer effects via its antiestrogenic activities. Unfortunately, TAM has been reported to exert gonadotoxic effects on male testes. Th
Externí odkaz:
https://doaj.org/article/5e2fb2eec81a42fea9d8b0e500282f66
Autor:
Bo Zhang, Zechao Qu, Hua Hui, Baorong He, Dong Wang, Yong Zhang, Yiwei Zhao, Jingjun Zhang, Liang Yan
Publikováno v:
Molecular Medicine, Vol 30, Iss 1, Pp 1-18 (2024)
Abstract Background Isoorientin (ISO) is a glycosylated flavonoid with antitumor, anti-inflammatory, and antioxidant properties. However, its effects on bone metabolism remain largely unknown. Methods In this study, we aimed to investigate the effect
Externí odkaz:
https://doaj.org/article/23da70e59f1a410cb7637a01a09cfed5
Autor:
Weijun Huang, Depeng Wu, Chaoyang Cai, Hui Yao, Zhenming Tian, Yang Yang, Mao Pang, Limin Rong, Bin Liu
Publikováno v:
Redox Biology, Vol 71, Iss , Pp 103104- (2024)
Aims: Spinal cord injury (SCI) is a devastating neurological disease that often results in tremendous loss of motor function. Increasing evidence demonstrates that diabetes worsens outcomes for patients with SCI due to the higher levels of neuronal o
Externí odkaz:
https://doaj.org/article/2822e87121cf4db4b6d03e89b102e18a
Autor:
Hua Rong, Xiaoming Li, Chunlei Yu, Wenbao Wang, Libo Li, Tianjiao Xu, Yisong Ding, Yingshi Su, Xiaoli Wang
Publikováno v:
Folia Neuropathologica, Vol 62, Iss 1, Pp 83-95 (2023)
Oxidative stress is a pivotal stimulating factor in neurocyte apoptosis and has been involved in the pathogenesis of Parkinson’s disease (PD). In this study, we have demonstrated that the improvement in the motor disorder of 1-methyl-4-phenyl-1,2,3
Externí odkaz:
https://doaj.org/article/3d6ea398533644a3957d877a4692fde3
Publikováno v:
Antioxidants, Vol 13, Iss 11, p 1287 (2024)
The increasing incidence of colorectal cancer and inflammatory diseases poses a major health concern, with oxidative stress playing a significant role in the onset of these pathologies. Factors such as excessive consumption of sugar-rich and fatty fo
Externí odkaz:
https://doaj.org/article/828d7c7cb6414a3481142606b033c43e
Autor:
Giovanni Tossetta, Sonia Fantone, Lucrezia Togni, Andrea Santarelli, Fabiola Olivieri, Daniela Marzioni, Maria Rita Rippo
Publikováno v:
Antioxidants, Vol 13, Iss 10, p 1270 (2024)
Periodontitis affects up to 40% of adults over 60 years old and is a consequence of gingivitis. Periodontitis is characterized by a chronic inflammation, periodontal damage, and alveolar bone resorption. The nuclear factor erythroid 2-related factor
Externí odkaz:
https://doaj.org/article/62e39327edfd4b6f9e7c7f471b419d73
Publikováno v:
Biomolecules & Biomedicine (2024)
The enzyme glutamate-cysteine ligase modifier subunit (GCLM) serves as the initial rate-limiting factor in glutathione (GSH) synthesis. GSH is the preferred substrate for glutathione peroxidase 4 (GPX4), directly impacting its activity and stability.
Externí odkaz:
https://doaj.org/article/034685b021ed4397a7ac18a565c8564d
Autor:
Tharani Mohanasundaram, Vadivelan Ramachandran, Bhargav Bhongiri, Emdormi Rymbai, Rinu Mary Xavier, Gaddam Narasimha Rao, Chintha Narendar
Publikováno v:
Pharmaceutical Sciences, Vol 29, Iss 3, Pp 255-262 (2023)
Wound healing is a complicated, organised process that includes numerous phases that connect diverse cellular events and activate several intracellular molecular pathways in injured cells and tissues. Delay in wound healing owing to high levels of ox
Externí odkaz:
https://doaj.org/article/7c328d0fff244d9fbe273f163c5bcf3b