Pterostilbene alleviates hydrogen peroxide-induced oxidative stress via nuclear factor erythroid 2 like 2 pathway in mouse preimplantation embryos

Autor: Obaid ULLAH, Zhongshu LI, Ihsan ALI, Lijie XU, Haixing LIU, Syed Zahid Ali SHAH, Nanzhu FANG

Publikováno v: The Journal of Reproduction and Development, Vol 65, Iss 1, Pp 73-81 (2018)

Pterostilbene (PTS) in blueberries is a phytoalexin with antioxidant properties. PTS exerts strong cytoprotective effects on various cells via Nuclear Factor Erythroid 2 like 2 (NFE2L2) pathway. We evaluated the antioxidant PTS treatment in mouse pre

Externí odkaz: https://doaj.org/article/722d936efc154e30a3fc7f230f26fad7

Phosphorylation regulates cullin-based ubiquitination in tumorigenesis

Autor: Meidan Ying, Xuejing Shao, Hong Zhu, Ji Cao, Bo Yang, Yifan Chen, Qiaojun He

Publikováno v: Acta Pharmaceutica Sinica B, Vol 11, Iss 2, Pp 309-321 (2021)
Acta Pharmaceutica Sinica. B

Cullin-RING ligases (CRLs) recognize and interact with substrates for ubiquitination and degradation, and can be targeted for disease treatment when the abnormal expression of substrates involves pathologic processes. Phosphorylation, either of subst

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f27b7f488f3a53677836e1b8e5b2722d
https://doi.org/10.1016/j.apsb.2020.09.007

Prokineticin Receptor-1 Signaling Inhibits Dose- and Time-Dependent Anthracycline-Induced Cardiovascular Toxicity Via Myocardial and Vascular Protection

Autor: Brigitte Escoubet, Laurent Désaubry, Adeline Gasser, Marine Charavin, Michael W. Y. Chan, Anais Audebrand, Daniela Cardinale, Pavel Karpov, Canan G. Nebigil, Igor V. Tetko, Ayhan Daglayan, Yu-Wen Chen

Publikováno v: JACC. CardioOncology, Vol 1, Iss 1, Pp 84-102 (2019)
JACC: CardioOncology
JACC: CardioOncology, Elsevier, 2019, 1 (1), pp.84-102. ⟨10.1016/j.jaccao.2019.06.003⟩
JACC CardioOncology
JACC CardioOncology, 2019, 1 (1), pp.84-102. ⟨10.1016/j.jaccao.2019.06.003⟩

Objectives This study investigated how different concentrations of doxorubicin (DOX) can affect the function of cardiac cells. This study also examined whether activation of prokineticin receptor (PKR)-1 by a nonpeptide agonist, IS20, prevents DOX-in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::deb816b6ed59e9b54a853d3cf450c545
http://www.sciencedirect.com/science/article/pii/S2666087319300043

The NRF2, Thioredoxin, and Glutathione System in Tumorigenesis and Anticancer Therapies

Autor: Neven Zarkovic, Suzana Borović Šunjić, Lidija Milkovic, Morana Jaganjac

Publikováno v: Antioxidants
Antioxidants, Vol 9, Iss 1151, p 1151 (2020)

Cancer remains an elusive, highly complex disease and a global burden. Constant change by acquired mutations and metabolic reprogramming contribute to the high inter- and intratumor heterogeneity of malignant cells, their selective growth advantage,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59207baf69a35caa847a03ad9c9d3a6d
http://europepmc.org/articles/PMC7699519

Corilagin induces apoptosis and autophagy in NRF2‑addicted U251 glioma cell line

Autor: Shu Jia, Xianyun Qin, Xinlin Yang, Feng Jin, Wenyuan Ma, Jilan Liu, Xiaobei Zhang, Dongfeng Pan

Publikováno v: Molecular Medicine Reports

Corilagin, extracted from the Euphorbiaceae and Phyllanthus plants, inhibits the growth of a number of types of tumors. Compared with temozolomide, the traditional chemotherapy drug, corilagin has demonstrated stronger antitumor activity. However, th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f1cc5066124048bf23881e82b467d50e
https://pubmed.ncbi.nlm.nih.gov/33760110