Výsledky vyhledávání - "nuclear calcium"

Akademický článek

Store-Operated Calcium Entry Increases Nuclear Calcium in Adult Rat Atrial and Ventricular Cardiomyocytes

Autor: Julia Hermes, Vesela Borisova, Jens Kockskämper

Publikováno v: Cells, Vol 12, Iss 23, p 2690 (2023)

Store-operated calcium entry (SOCE) in cardiomyocytes may be involved in cardiac remodeling, but the underlying mechanisms remain elusive. We hypothesized that SOCE may increase nuclear calcium, which alters gene expression via calcium/calmodulin-dep

Externí odkaz: https://doaj.org/article/b5161b4f164c4e2da78d7230464ac229

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Akademický článek

Computational analysis of cortical neuronal excitotoxicity in a large animal model of neonatal brain injury

Autor: Panagiotis Kratimenos, Abhya Vij, Robinson Vidva, Ioannis Koutroulis, Maria Delivoria-Papadopoulos, Vittorio Gallo, Aaron Sathyanesan

Publikováno v: Journal of Neurodevelopmental Disorders, Vol 14, Iss 1, Pp 1-16 (2022)

Abstract Background Neonatal hypoxic brain injury is a major cause of intellectual and developmental disability. Hypoxia causes neuronal dysfunction and death in the developing cerebral cortex due to excitotoxic Ca2+-influx. In the translational pigl

Externí odkaz: https://doaj.org/article/bfbd70b4100442eca832757bd4e54d0b

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Akademický článek

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Akademický článek

Epigenetic regulation of osteopontin splicing isoform c defines its role as a microenvironmental factor to promote the survival of colon cancer cells from 5-FU treatment

Autor: Siyuan Chang, Jing Huang, Huan Niu, Jing Wang, Yang Si, Zhigang Bai, Shan Cheng, Wei Ding

Publikováno v: Cancer Cell International, Vol 20, Iss 1, Pp 1-16 (2020)

Abstract Background Drug resistance to 5-fluorouracil (5-FU) and recurrence after chemotherapy in colorectal cancer remain a challenge to be resolved for the improvement of patient outcomes. It is recognized that a variety of secretory proteins relea

Externí odkaz: https://doaj.org/article/867d922691d443f28d5938b0d0ae2567

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Akademický článek

LINC-complex mediated positioning of the vegetative nucleus is involved in calcium and ROS signaling in Arabidopsis pollen tubes

Autor: Morgan Moser, Andrew Kirkpatrick, Norman Reid Groves, Iris Meier

Publikováno v: Nucleus, Vol 11, Iss 1, Pp 149-163 (2020)

Nuclear movement and positioning play a role in developmental processes throughout life. Nuclear movement and positioning are mediated primarily by linker of nucleoskeleton and cytoskeleton (LINC) complexes. LINC complexes are comprised of the inner

Externí odkaz: https://doaj.org/article/bbd0d6d02eab4b86a2f059dc922f3073

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Akademický článek

Nuclear Calcium in Cardiac (Patho)Physiology: Small Compartment, Big Impact

Autor: Mara Kiessling, Nataša Djalinac, Julia Voglhuber, Senka Ljubojevic-Holzer

Publikováno v: Biomedicines, Vol 11, Iss 3, p 960 (2023)

The nucleus of a cardiomyocyte has been increasingly recognized as a morphologically distinct and partially independent calcium (Ca2+) signaling microdomain, with its own Ca2+-regulatory mechanisms and important effects on cardiac gene expression. In

Externí odkaz: https://doaj.org/article/c683cc35d6ca417296af98bea0fee550

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