Výsledky vyhledávání

Akademický článek

Cheminformatics approach to identify andrographolide derivatives as dual inhibitors of methyltransferases (nsp14 and nsp16) of SARS-CoV-2

Autor: Jobin Thomas, Anupam Ghosh, Shivendu Ranjan, Jitendra Satija

Publikováno v: Scientific Reports, Vol 14, Iss 1, Pp 1-18 (2024)

Abstract The Covid-19 pandemic outbreak has accelerated tremendous efforts to discover a therapeutic strategy that targets severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) to control viral infection. Various viral proteins have been ident

Externí odkaz: https://doaj.org/article/5061d0b82e854b41a6ea9d68df3faaa3

Zobrazit plný text záznamu

Plný text ve formátu HTML

Akademický článek

First report on the QSAR modelling and multistep virtual screening of the inhibitors of nonstructural protein Nsp14 of SARS-CoV-2: Reducing unnecessary chemical synthesis and experimental tests

Autor: Qianqian Wang, Tengjiao Fan, Runqing Jia, Na Zhang, Lijiao Zhao, Rugang Zhong, Guohui Sun

Publikováno v: Arabian Journal of Chemistry, Vol 17, Iss 3, Pp 105614- (2024)

Corona Virus Disease 2019 (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), poses a serious threat to human health and life safety. How to effectively prevent and treat COVID-19 is crucial. In this study, we used

Externí odkaz: https://doaj.org/article/251e5f1ad2e14ab3b23be90e3846796e

Zobrazit plný text záznamu

Akademický článek

Antiviral Potential of Antillogorgia americana and elisabethae Natural Products against nsp16–nsp10 Complex, nsp13, and nsp14 Proteins of SARS-CoV-2: An In Silico Investigation

Autor: Omkar Pokharkar, Hariharan Lakshmanan, Grigory V. Zyryanov, Mikhail V. Tsurkan

Publikováno v: Microbiology Research, Vol 14, Iss 3, Pp 993-1019 (2023)

Biomolecules of marine origin have many applications in the field of biotechnology and medicine, but still hold great potential as bioactive substances against different diseases. The purification or total synthesis of marine metabolites is expensive

Externí odkaz: https://doaj.org/article/08aef05803c644189e1562c885083514

Zobrazit plný text záznamu

Plný text ve formátu HTML

Akademický článek

A universal fluorescence polarization high throughput screening assay to target the SAM-binding sites of SARS-CoV-2 and other viral methyltransferases

Autor: Subodh Kumar Samrat, Qamar Bashir, Ran Zhang, Yiding Huang, Yuchen Liu, Xiangmeng Wu, Tyler Brown, Wei Wang, Y. George Zheng, Qing-Yu Zhang, Yin Chen, Zhong Li, Hongmin Li

Publikováno v: Emerging Microbes and Infections, Vol 12, Iss 1 (2023)

ABSTRACTSARS-CoV-2 has caused a global pandemic with significant humanity and economic loss since 2020. Currently, only limited options are available to treat SARS-CoV-2 infections for vulnerable populations. In this study, we report a universal fluo

Externí odkaz: https://doaj.org/article/60c51fd2806c487b8bf9c42761d4bf04

Zobrazit plný text záznamu

Akademický článek

Structure-Based Virtual Screening for Methyltransferase Inhibitors of SARS-CoV-2 nsp14 and nsp16

Autor: Kejue Wu, Yinfeng Guo, Tiefeng Xu, Weifeng Huang, Deyin Guo, Liu Cao, Jinping Lei

Publikováno v: Molecules, Vol 29, Iss 10, p 2312 (2024)

The ongoing COVID-19 pandemic still threatens human health around the world. The methyltransferases (MTases) of SARS-CoV-2, specifically nsp14 and nsp16, play crucial roles in the methylation of the N7 and 2′-O positions of viral RNA, making them p

Externí odkaz: https://doaj.org/article/f7e23fdccba145b7936c5e6464a34c43

Zobrazit plný text záznamu

Plný text ve formátu HTML

Akademický článek

Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.

Akademický článek

Expression and enzymatic activity analysis of non-structure protein 14 of SARS-CoV-2

Autor: CHEN Shuang, XU Jingwen, DING Kaiyun, LIU Jiansheng, PENG Xiaozhong, LIU Hongqi

Publikováno v: Jichu yixue yu linchuang, Vol 43, Iss 1, Pp 51-58 (2023)

Objective To obtain the non-structure protein 14 (Nsp14) of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2) with higher purity and enzymatic activity. Methods This study firstly analyzed the rare codons in the gene of nsp14 according to t

Externí odkaz: https://doaj.org/article/b039da4fb7144b748acdb4c70d9f707a

Zobrazit plný text záznamu