Zobrazeno 1 - 10
of 234
pro vyhledávání: '"nsp12"'
Autor:
FERNANDO B. ZANCHI, GABRIEL EDUARDO M. FERREIRA, LUIS ANDRÉ M. MARIÚBA, JULIANE C. GLÓRIA, VALDINETE A. DO NASCIMENTO, VICTOR C. DE SOUZA, ANDRÉ DE LIMA G. CORADO, FERNANDA O. DO NASCIMENTO, ÁGATHA KÉLLY A. DA COSTA, DÉBORA CAMILA G. DUARTE, GEORGE ALLAN V. DA SILVA, MATILDE DEL CARMEN C. MEJÍA, KARINA P. PESSOA, LUCIANA MARA F. GONÇALVES, MARIA JÚLIA P. BRANDÃO, MICHELE S. DE JESUS, MARINEIDE S. DA SILVA, CRISTIANO F. DA COSTA, FELIPE G. NAVECA
Publikováno v:
Anais da Academia Brasileira de Ciências, Vol 96, Iss 2 (2024)
Abstract The disease coronavirus COVID-19 has been the cause of millions of deaths worldwide. Among the proteins of SARS-CoV-2, non-structural protein 12 (NSP12) plays a key role during COVID infection and is part of the RNA-dependent RNA polymerase
Externí odkaz:
https://doaj.org/article/498199b43dc84421842469a29f54501e
Publikováno v:
Microbiology Research, Vol 14, Iss 3, Pp 1020-1048 (2023)
The genus Laurencia, a category of marine red algae, is well recognized for producing a large variety of natural products (NPs) that are both chemically intriguing and structurally distinct. The aim of this research was to identify NPs with potential
Externí odkaz:
https://doaj.org/article/e86943227d504457a417149a74fad2d0
Publikováno v:
Emerging Microbes and Infections, Vol 12, Iss 1 (2023)
ABSTRACTDisruption of the cell cycle is a common strategy shared by many viruses to create a conducible cellular microenvironment for their efficient replication. We have previously shown that infection of cells with gammacoronavirus infectious bronc
Externí odkaz:
https://doaj.org/article/6db4f8469f744ebbbf38a37216c5f67a
Autor:
Hannah Goldswain, Xiaofeng Dong, Rebekah Penrice-Randal, Muhannad Alruwaili, Ghada T. Shawli, Tessa Prince, Maia Kavanagh Williamson, Jayna Raghwani, Nadine Randle, Benjamin Jones, I’ah Donovan-Banfield, Francisco J. Salguero, Julia A. Tree, Yper Hall, Catherine Hartley, Maximilian Erdmann, James Bazire, Tuksin Jearanaiwitayakul, Malcolm G. Semple, Peter J. M. Openshaw, J. Kenneth Baillie, ISARIC4C Investigators, Stevan R. Emmett, Paul Digard, David A. Matthews, Lance Turtle, Alistair C. Darby, Andrew D. Davidson, Miles W. Carroll, Julian A. Hiscox
Publikováno v:
Genome Biology, Vol 24, Iss 1, Pp 1-23 (2023)
Abstract Background The mutational landscape of SARS-CoV-2 varies at the dominant viral genome sequence and minor genomic variant population. During the COVID-19 pandemic, an early substitution in the genome was the D614G change in the spike protein,
Externí odkaz:
https://doaj.org/article/b3d75d58548e46f4b79481a60a9b08d2
Autor:
Mitsuhiro Machitani, Junko Takei, Mika K. Kaneko, Saori Ueki, Hirofumi Ohashi, Koichi Watashi, Yukinari Kato, Kenkichi Masutomi
Publikováno v:
Virology Journal, Vol 19, Iss 1, Pp 1-7 (2022)
Abstract A novel coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has caused a global pandemic of coronavirus disease 19. Coronaviruses, including SARS-CoV-2, use RNA-dependent RNA polymerase (RdRP) for viral replication and
Externí odkaz:
https://doaj.org/article/9b3511abc401438c8aa06c49d4bc76c8
Autor:
Yujiao Zhang, Ning Kong, Jinfeng Ti, Dongshen Cao, Zhaofeng Sui, Aimin Ge, Liuting Pan, Kuan Zhao, Yanjun Zhou, Guangzhi Tong, Liwei Li, Fei Gao
Publikováno v:
Virus Research, Vol 334, Iss , Pp 199181- (2023)
Porcine reproductive and respiratory syndrome virus (PRRSV) has seriously affected the viability of swine industries worldwide, and effective measures to control PRRSV are urgently required. Understanding the mechanisms of action of antiviral protein
Externí odkaz:
https://doaj.org/article/8d6156ae3cb6471693c75f57ba34f1f9
Autor:
Charlotte Hedskog, Christoph D. Spinner, Ulrike Protzer, Dieter Hoffmann, Chunkyu Ko, Robert L. Gottlieb, Medhat Askar, Meta Roestenberg, Jutte J. C. de Vries, Ellen C. Carbo, Ross Martin, Jiani Li, Dong Han, Lauren Rodriguez, Aiyappa Parvangada, Jason K. Perry, Ricard Ferrer, Andrés Antón, Cristina Andrés, Vanessa Casares, Huldrych F. Günthard, Michael Huber, Grace A. McComsey, Navid Sadri, Judith A. Aberg, Harm van Bakel, Danielle P. Porter
Publikováno v:
Viruses, Vol 16, Iss 4, p 546 (2024)
Remdesivir (RDV) is a broad-spectrum nucleotide analog prodrug approved for the treatment of COVID-19 in hospitalized and non-hospitalized patients with clinical benefit demonstrated in multiple Phase 3 trials. Here we present SARS-CoV-2 resistance a
Externí odkaz:
https://doaj.org/article/96f39a75be5a4ab7bceddaed4be70324
Akademický článek
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Akademický článek
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Autor:
Tim Westphal, Maria Mader, Hendrik Karsten, Leon Cords, Maximilian Knapp, Sophia Schulte, Lennart Hermanussen, Sven Peine, Vanessa Ditt, Alba Grifoni, Marylyn Martina Addo, Samuel Huber, Alessandro Sette, Marc Lütgehetmann, Sven Pischke, William W. Kwok, John Sidney, Julian Schulze zur Wiesch
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
IntroductionThe nonstructural protein 12 (NSP12) of the severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) has a high sequence identity with common cold coronaviruses (CCC).MethodsHere, we comprehensively assessed the breadth and speci
Externí odkaz:
https://doaj.org/article/152e556c36f64ae28b52cfd9330f429a