Zobrazeno 1 - 10
of 1 680
pro vyhledávání: '"nrf1"'
Autor:
Yuhua Chen, Wei He, Junlin Qiu, Yangyang Luo, Chenlong Jiang, Feng Zhao, Hong Wei, Jiao Meng, Tianlin Long, Xin Zhang, Lingjian Yang, Quanhua Xu, Juning Wang, Chi Zhang
Publikováno v:
Cellular & Molecular Biology Letters, Vol 29, Iss 1, Pp 1-19 (2024)
Abstract Background Stroke is a type of acute brain damage that can lead to a series of serious public health challenges. Demonstrating the molecular mechanism of stroke-related neural cell degeneration could help identify a more efficient treatment
Externí odkaz:
https://doaj.org/article/34d667dcbe0543f0ac7a3b8bcfc430c7
Publikováno v:
Molecular Medicine, Vol 30, Iss 1, Pp 1-18 (2024)
Abstract Objective Catalpol (CAT) has various pharmacological activities and plays a protective role in cerebral ischemia. It has been reported that CAT played a protective role in cerebral ischemia by upregulaing NRF1 expression. Bioinformatics anal
Externí odkaz:
https://doaj.org/article/fd4791c6a8184b19a61585d0d0f4e670
Publikováno v:
BMC Gastroenterology, Vol 24, Iss 1, Pp 1-14 (2024)
Abstract Background Cellular response to oxidative stress plays significant roles in hepatocellular carcinoma (HCC) development, yet the exact mechanism by which HCC cells respond to oxidative stress remains poorly understood. This study aimed to inv
Externí odkaz:
https://doaj.org/article/71eb220e054c465dbeb776d46a40fab2
Akademický článek
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Publikováno v:
Poultry Science, Vol 103, Iss 5, Pp 103559- (2024)
ABSTRACT: Peroxisome proliferator-activated receptor gamma (PPARγ) is a master regulator of adipogenesis. Our previous study revealed that chicken PPARγ has 3 alternative promoters named as P1, P2, and P3, and the DNA methylation of promoter P3 was
Externí odkaz:
https://doaj.org/article/fc7b2adef2f04856ba6d3e652af3a30f
Autor:
Longqing Zhang, Xi Tan, Fanhe Song, Danyang Li, Jiayi Wu, Shaojie Gao, Jia Sun, Daiqiang Liu, Yaqun Zhou, Wei Mei
Publikováno v:
Neural Regeneration Research, Vol 19, Iss 3, Pp 687-696 (2024)
[INLINE:1] Activated G-protein-coupled receptor 39 (GPR39) has been shown to attenuate inflammation by interacting with sirtuin 1 (SIRT1) and peroxisome proliferator-activated receptor-γ coactivator 1α (PGC-1α). However, whether GPR39 attenuates n
Externí odkaz:
https://doaj.org/article/ca49ab450884405cab71986702925e8d
Autor:
Ibtisam Ibtisam, Alexei F Kisselev
Publikováno v:
eLife, Vol 12 (2024)
Rapid recovery of proteasome activity may contribute to intrinsic and acquired resistance to FDA-approved proteasome inhibitors. Previous studies have demonstrated that the expression of proteasome genes in cells treated with sub-lethal concentration
Externí odkaz:
https://doaj.org/article/ec3366ebac70432489762ebcacf7a7b2
Autor:
Kuei-Pin Chung, Jia-Ying Su, Yi-Fu Wang, Bugi Ratno Budiarto, Yu-Chang Yeh, Jui-Chen Cheng, Li-Ta Keng, Yi-Jung Chen, Ya-Ting Lu, Yi-Hsiu Juan, Kiichi Nakahira, Sheng-Yuan Ruan, Jung-Yien Chien, Hou-Tai Chang, Jih-Shuin Jerng, Yen-Tsung Huang, Shih-Yu Chen, Chong-Jen Yu
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
Immunosuppression increases the risk of nosocomial infection in patients with chronic critical illness. This exploratory study aimed to determine the immunometabolic signature associated with nosocomial infection during chronic critical illness. We p
Externí odkaz:
https://doaj.org/article/203f011c9cd94ad7a338b0806a57c947
Publikováno v:
Redox Biology, Vol 69, Iss , Pp 103003- (2024)
The failure of the proper protein turnover in the nervous system is mainly linked to a variety of neurodegenerative disorders. Therefore, a better understanding of key protein degradation through the ubiquitin-proteasome system is critical for effect
Externí odkaz:
https://doaj.org/article/a044a849571e4afeb0c01142f0e4fac6
Autor:
Ran Liu, Chuanzheng Yin, Peng Zhao, Bing Guo, Wenbo Ke, Xichuan Zheng, Dawei Xie, Yaofeng Wang, Gengqiao Wang, Yinzhao Jia, Yang Gao, Wenjun Hu, Gang Logan Liu, Zifang Song
Publikováno v:
Biology Direct, Vol 18, Iss 1, Pp 1-20 (2023)
Abstract Background Nuclear respiratory factor 1 (NRF1) is a transcription factor that participates in several kinds of tumor, but its role in hepatocellular carcinoma (HCC) remains elusive. This study aims to explore the role of NRF1 in HCC progress
Externí odkaz:
https://doaj.org/article/e635c01c6d284aeb851bb10e8042d600