Zobrazeno 1 - 10
of 694
pro vyhledávání: '"nr4a1"'
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-13 (2024)
Abstract As an ultra-early response gene, Nuclear receptor 4A1 (NR4A1) has been reported to be involved in the development of various diseases through various pathological pathways, but its specific mechanism in chronic kidney disease (CKD) is unknow
Externí odkaz:
https://doaj.org/article/c657b3a26bee424a8a4b84529a739f82
Autor:
Xiangyu Zhai, Hao Zhang, Zhijia Xia, Mingkun Liu, Gang Du, Zhengchen Jiang, Huaxin Zhou, Dan Luo, Dandan Dou, Jingxin Li, Wei Wang, Xiaosong Li, Bin Jin
Publikováno v:
JHEP Reports, Vol 6, Iss 6, Pp 101032- (2024)
Background & Aims: Previous studies demonstrated oxytocin treatment effectiveness in reducing mortality and reversing liver fibrosis in mice. However, the underlying mechanism remains obscure, given the absence of oxytocin receptor expression in hepa
Externí odkaz:
https://doaj.org/article/b4c192bc998b463fa37e93c29b149316
Autor:
Ryota TERASHIMA, Daiki NAGAO, Masato IKEO, Keisuke MORIOKA, Titaree LAOHARATCHATATHANIN, Shiro KURUSU, Mitsumori KAWAMINAMI
Publikováno v:
The Journal of Reproduction and Development, Vol 70, Iss 2, Pp 115-122 (2024)
The NR4A nuclear receptor family (NR4As), encompassing NR4A1, NR4A2, and NR4A3, exerts pivotal roles in cellular processes through intricate expression patterns and interactions. Despite the influence of some NR4As on anterior pituitary functions reg
Externí odkaz:
https://doaj.org/article/2586248e326f41b39f11280845db9610
Publikováno v:
Jichu yixue yu linchuang, Vol 43, Iss 10, Pp 1608-1611 (2023)
As a member of the nuclear receptor subfamily, NR4A1 works with glycerol kinase, a key glucose and lipid metabolism enzyme, to lower blood glucose and boost blood lipids and maintain glucose and lipid homeostasis, while NR4A1 deficiency leads to disr
Externí odkaz:
https://doaj.org/article/971860a93984445b848db50899d21a32
Autor:
Shasha Xu, Yu Zhang, Xingjie Liu, Huisheng Liu, Xinya Zou, Linlin Zhang, Jing Wang, Zhiwei Zhang, Xiang Xu, Mingxia Li, Kairui Li, Shuyue Shi, Ying Zhang, Zhichao Miao, Jie Zha, Yong Yu
Publikováno v:
BMC Biology, Vol 21, Iss 1, Pp 1-17 (2023)
Abstract Background Group 2 innate lymphoid cells (ILC2s) are critical sources of type 2 cytokines and represent one of the major tissue-resident lymphoid cells in the mouse lung. However, the molecular mechanisms underlying ILC2 activation under cha
Externí odkaz:
https://doaj.org/article/b482f366b34f4b44b2fbdc8a6e1c623b
Autor:
Jiani Xing, Jianying Zheng, Sheng Cui, Jinling Wang, Yong Wang, Yanyan Li, Jiangjiang Zhu, Yaqiu Lin
Publikováno v:
Animals, Vol 14, Iss 14, p 2051 (2024)
As a transcription factor, Nuclear Receptor Subfamily 4 Group A Member 1 (NR4A1) binds to downstream target genes to participate in cell proliferation and cell differentiation. We found that the NR4A1 reached the highest expression at 60 h after the
Externí odkaz:
https://doaj.org/article/49030a40bfb04698ac54b3ab3c802428
Autor:
Sara Wernig-Zorc, Uwe Schwartz, Paulina Martínez-Rodríguez, Josefa Inalef, Francisca Pavicic, Pamela Ehrenfeld, Gernot Längst, Rodrigo Maldonado
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 10, p 5515 (2024)
Long non-coding RNAs (lncRNAs) have been shown to modulate gene expression and are involved in the initiation and progression of various cancer types. Despite the wealth of studies describing transcriptome changes upon lncRNA knockdown, there is limi
Externí odkaz:
https://doaj.org/article/3248173163b74be5816c3c6c4b335965
Publikováno v:
Frontiers in Pharmacology, Vol 14 (2023)
Piperlongumine and derivatives are being developed as anticancer agents which act primarily as inducers of reactive oxygen species (ROS) in cancer cell lines. Many of the anticancer activities of piperlongumine resemble those observed for bis-indole
Externí odkaz:
https://doaj.org/article/ef078db5186846df887b22b853632a10
Publikováno v:
Acta Materia Medica, Vol 2, Iss 1, Pp 72-83 (2023)
Diabetic kidney disease (DKD) is one of the leading causes of end-stage renal disease. Verbascoside is a ubiquitous phenylethanoid glycoside with potent anti-inflammatory, antioxidant, and hypoglycemic properties. This study determined the renoprotec
Externí odkaz:
https://doaj.org/article/11304821ca7847f5ab91497f12aac2d7