A Fine-Tuned Lipophilicity/Hydrophilicity Ratio Governs Antibacterial Potency and Selectivity of Bifurcated Halogen Bond-Forming NBTIs

Autor: Irena Zdovc, Matjaž Weiss, Marko Anderluh, Anja Kolarič, Simon Žakelj, Martina Hrast, Jurij Trontelj, Maja Kokot, Nikola Minovski

Publikováno v: Antibiotics
Volume 10
Issue 7
Antibiotics, 30 str. : Ilustr., tabele, Vol. 10, no. 7, art. 862, 2021
COBISS-ID: 522975769
Antibiotics, Vol 10, Iss 862, p 862 (2021)
Antibiotics, vol. 10, no. 7, 862, 2021.

Herein, we report the design of a focused library of novel bacterial topoisomerase inhibitors (NBTIs) based on innovative mainly monocyclic right-hand side fragments active against DNA gyrase and Topo IV. They exhibit a very potent and wide range of

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