Zobrazeno 1 - 10
of 94
pro vyhledávání: '"novel therapeutic approaches"'
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
Rheumatoid arthritis is a widely prevalent autoimmune bone disease that imposes a significant burden on global healthcare systems due to its increasing incidence. In recent years, attention has focused on the interaction between gut homeostasis and t
Externí odkaz:
https://doaj.org/article/3aec71b24110436088408cf473aad9e3
Publikováno v:
Translational Medicine of Aging, Vol 7, Iss , Pp 52-65 (2023)
The underlying molecular mechanisms associated with sporadic Alzheimer's disease (AD), a progressive neurodegenerative disease, are not yet fully understood. Adult neurons are post-mitotic cells that may need to survive for as long as the lifespan of
Externí odkaz:
https://doaj.org/article/3984d61531fd43ffb6c5e91907835bae
Publikováno v:
Frontiers in Pharmacology, Vol 14 (2023)
Externí odkaz:
https://doaj.org/article/a9f01ab9482642d78afda3767cc8b5a1
Publikováno v:
Frontiers in Physiology, Vol 12 (2022)
Externí odkaz:
https://doaj.org/article/e231fe54ea4c4b3d9097e8c24f1576be
Autor:
Margherita Protasoni, Manuel Serrano
Publikováno v:
Pharmaceutics, Vol 15, Iss 2, p 352 (2023)
Ageing is accompanied by a progressive impairment of cellular function and a systemic deterioration of tissues and organs, resulting in increased vulnerability to multiple diseases. Here, we review the interplay between two hallmarks of ageing, namel
Externí odkaz:
https://doaj.org/article/d7ace0c289464746bf058e9eb069f807
Akademický článek
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Publikováno v:
Frontiers in Physiology, Vol 10 (2019)
Externí odkaz:
https://doaj.org/article/092d3368332e4d1d915bae38818b3f35
Autor:
Cristina Scavone, Gabriella di Mauro, Annamaria Mascolo, Liberato Berrino, Francesco Rossi, Annalisa Capuano
Publikováno v:
Frontiers in Pharmacology, Vol 10 (2019)
Despite several innovative medicines gaining worldwide approval in recent years, there are still therapeutic areas for which unsatisfied therapeutic needs persist. For example, high unmet clinical need was observed in patients diagnosed with type 2 d
Externí odkaz:
https://doaj.org/article/ec6c1e3fa9a04931972010f5a19ef2ab
Autor:
Ken Kudura, Nando Ritz, Arnoud J. Templeton, Tim Kutzker, Robert Foerster, Kwadwo Antwi, Michael C. Kreissl, Martin H. K. Hoffmann
Publikováno v:
Journal of Clinical Medicine; Volume 12; Issue 11; Pages: 3725
Objectives: We aimed to assess the predictive value of the total metabolic tumor burden prior to treatment in patients with advanced non-small-cell lung cancer (NSCLC) receiving immune checkpoint inhibitors (ICIs). Methods: Pre-treatment 2-deoxy-2-[1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de92ab71e1ba64175a0ba6af7b301582
Autor:
Rongbin Wei, Hui Dai, Jing Zhang, David J. H. Shih, Yulong Liang, Pengfeng Xiao, Daniel J. McGrail, Shiaw-Yih Lin
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 9, p 5008 (2021)
Nucleotide excision repair (NER) resolves DNA adducts, such as those caused by ultraviolet light. Deficient NER (dNER) results in a higher mutation rate that can predispose to cancer development and premature ageing phenotypes. Here, we used isogenic
Externí odkaz:
https://doaj.org/article/c57710a5fdfe4dc8ba9b8e0df341e6b1