Zobrazeno 1 - 10
of 179
pro vyhledávání: '"novel compound"'
Publikováno v:
Frontiers in Chemistry, Vol 12 (2024)
BackgroundPonatinib, a third-generation tyrosine kinase inhibitor, is employed in the management of adult chronic myeloid leukemia. Nevertheless, the presence of process impurities and degradation impurities linked to ponatinib may potentially influe
Externí odkaz:
https://doaj.org/article/fd2fc9fdd70e4169906222d2312a64ae
Publikováno v:
Molecules, Vol 29, Iss 4, p 812 (2024)
One new compound with an isoindolinone skeleton, along with erinacines A, C, and S, was isolated from the mycelia of Hericium erinaceus, an edible fungus with a long history of use in traditional Chinese medicine. Based on analysis of MS and NMR spec
Externí odkaz:
https://doaj.org/article/f200d92532c54d4cafa713a8836877e1
Autor:
Shu Zhang, Yuanyuan Geng, Bin Wei, Yangzhen Lu, Lihua He, Fei Zhao, Jianzhong Zhang, Zhaohai Qin, Jie Gong
Publikováno v:
Journal of Fungi, Vol 10, Iss 1, p 28 (2023)
The current increase in resistance to antifungal drugs indicates that there is an urgent need to explore novel antifungal drugs with different mechanisms of action. Phosundoxin is a biphenyl aliphatic amide using a TPP-targeting strategy which target
Externí odkaz:
https://doaj.org/article/78bd37ecebae427aa7fe390dbdce9a7b
Publikováno v:
Journal of Experimental Pharmacology, Vol Volume 14, Pp 73-85 (2022)
Heta Dinesh Bhatt,1 Steve A McClain,2 Hsi-Ming Lee,1 Thomas Zimmerman,3 Jie Deng,4 Francis Johnson,5 Ying Gu,6 Lorne M Golub1 1Department of Oral Biology and Pathology, School of Dental Medicine, Stony Brook University, Stony Brook, NY, 11794, USA; 2
Externí odkaz:
https://doaj.org/article/f0dfc270fe604b3bb2435a0adb95cc82
Akademický článek
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Publikováno v:
Frontiers in Genetics, Vol 13 (2022)
Hearing loss is among the most common congenital sensory impairments. Genetic causes account for more than 50% of the cases of congenital hearing loss. The PTPRQ gene, encoding protein tyrosine phosphatase receptor Q, plays an important role in maint
Externí odkaz:
https://doaj.org/article/f1e9f571a3de4d57b80283b1a6825942
Publikováno v:
Journal of Analytical Science and Technology, Vol 11, Iss 1, Pp 1-7 (2020)
Abstract Background Bromophenol-thiosemicarbazone hybrid was a novel synthetic brominated anticancer compound with two bromine atoms. Bromophenol-thiosemicarbazone hybrid showed considerable selective inhibitory activity against PARP1 (IC50 = 29.5 nm
Externí odkaz:
https://doaj.org/article/ddebb1a4d150478e8916216e110e8bb7
Publikováno v:
Plants, Vol 12, Iss 8, p 1663 (2023)
Plant parts and extracts that are rich in bioactive substances with allelopathic potential can be explored as a possible alternative to herbicides for natural weed control in sustainable agriculture. In the present study, we investigated the allelopa
Externí odkaz:
https://doaj.org/article/01699ccc25fc41d7b58b2630ca3553aa
Autor:
Niu Li, Yufei Xu, Yi Zhang, Guoqiang Li, Tingting Yu, Ruen Yao, YunFang Zhou, Yiping Shen, Lei Yin, Xiumin Wang, Jian Wang
Publikováno v:
Orphanet Journal of Rare Diseases, Vol 14, Iss 1, Pp 1-10 (2019)
Abstract Background Gain-of-function pathogenic variants of the Erb-B2 receptor tyrosine kinase 3 (ERBB3) gene contribute to the occurrence and development of a variety of human carcinomas through activation of phosphatidylinositol 3-kinase (PI3K)/AK
Externí odkaz:
https://doaj.org/article/217ae3c3e0024e21ab1432f2235d6964
Autor:
He Liu, Mengnan An, Hongyang Si, Yuhang Shan, Chuantao Xu, Gang Hu, Yunbo Xie, Dongyang Liu, Shujun Li, Rui Qiu, Chong Zhang, Yuanhua Wu
Publikováno v:
Molecules, Vol 27, Iss 17, p 5649 (2022)
As an important microbial resource, Actinomycetes, especially Streptomyces, have important application values in medicine and biotechnology. Streptomyces fungicidicus SYH3 was isolated from soil samples in tomato-growing areas and showed good inhibit
Externí odkaz:
https://doaj.org/article/af8186cae1f347af96389dfec02ba77f