Zobrazeno 1 - 10
of 325
pro vyhledávání: '"notochordal cells"'
Autor:
RJ Williams, S Basatvat, TC Schmitz, R Janani, C Sammon, K Benz, K Ito, MA Tryfonidou, JW Snuggs, CL Le Maitre
Publikováno v:
European Cells & Materials, Vol 47, Pp 30-50 (2024)
Low back pain is the leading cause of disability worldwide and is strongly associated with degeneration of the intervertebral disc (IVD). During degeneration the nucleus pulposus (NP) in the core of the IVD, is affected by altered matrix synthesis, i
Externí odkaz:
https://doaj.org/article/ecbc35f4d0e5464bbf9c46ac76159d58
Autor:
LT Laagland, FC Bach, FM Riemers, G Erdmann, TS Braun, GGH van den Akker, TC Schmitz, LB Creemers, C Sachse, CL Le Maitre, TJM Welting, K Ito, MF Templin, MA Tryfonidou
Publikováno v:
European Cells & Materials, Vol 46, Pp 57-90 (2023)
Chronic low back pain is often caused by intervertebral disc (IVD) degeneration. Preceding this degenerative process, the main cellular phenotype in the nucleus pulposus shifts from notochordal cells (NCs) to nucleus pulposus cells (NPCs). In previou
Externí odkaz:
https://doaj.org/article/6c9eaeb63e37423c98fe5a62ccfa3925
Autor:
Martha E. Diaz-Hernandez, Kimihide Murakami, Shizumasa Murata, Nazir M. Khan, Sreekala P. V. Shenoy, Katrin Henke, Hiroshi Yamada, Hicham Drissi
Publikováno v:
Cells, Vol 13, Iss 17, p 1482 (2024)
Intervertebral disc disease (IDD) is a debilitating spine condition that can be caused by intervertebral disc (IVD) damage which progresses towards IVD degeneration and dysfunction. Recently, human pluripotent stem cells (hPSCs) were recognized as a
Externí odkaz:
https://doaj.org/article/963246b9f8c5434c82c6eabfec77d7aa
Autor:
Luca Ambrosio, Jordy Schol, Clara Ruiz-Fernández, Shota Tamagawa, Kieran Joyce, Akira Nomura, Elisabetta de Rinaldis, Daisuke Sakai, Rocco Papalia, Gianluca Vadalà, Vincenzo Denaro
Publikováno v:
Journal of Developmental Biology, Vol 12, Iss 3, p 18 (2024)
The intervertebral disc (IVD) is the largest avascular organ of the human body and plays a fundamental role in providing the spine with its unique structural and biomechanical functions. The inner part of the IVD contains the nucleus pulposus (NP), a
Externí odkaz:
https://doaj.org/article/fc459487d1d745b1afc705b5d2d945d1
Autor:
Büşra Günay, Elizabeth Matthews, Jack Morgan, Marianna A. Tryfonidou, Radka Saldova, Abhay Pandit
Publikováno v:
FASEB BioAdvances, Vol 5, Iss 8, Pp 321-335 (2023)
Abstract Degeneration of the intervertebral disc is an age‐related condition. It also accompanies the disappearance of the notochordal cells, which are remnants of the developmental stages of the nucleus pulposus (NP). Molecular changes such as ext
Externí odkaz:
https://doaj.org/article/a277ae4a05d344ca8e6de75ab1dc08ae
Autor:
Rebecca J. Williams, Lisanne T. Laagland, Frances C. Bach, Lizzy Ward, Wilson Chan, Vivian Tam, Adel Medzikovic, Shaghayegh Basatvat, Lily Paillat, Nicolas Vedrenne, Joseph W. Snuggs, Deepani W. Poramba‐Liyanage, Judith A. Hoyland, Danny Chan, Anne Camus, Stephen M. Richardson, Marianna A. Tryfonidou, Christine L. Le Maitre
Publikováno v:
JOR Spine, Vol 6, Iss 3, Pp n/a-n/a (2023)
Abstract Background Lineage‐tracing experiments have established that the central region of the mature intervertebral disc, the nucleus pulposus (NP), develops from the embryonic structure called “the notochord”. However, changes in the cells d
Externí odkaz:
https://doaj.org/article/dfa01fb81efe46eab3be07a579ca5024
Akademický článek
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Akademický článek
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Akademický článek
Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.
K zobrazení výsledku je třeba se přihlásit.
Autor:
Zhuochao Liu, Zhiyong Zheng, Jin Qi, Jun Wang, Qi Zhou, Fangqiong Hu, Jing Liang, Changwei Li, Weibin Zhang, Xingkai Zhang
Publikováno v:
Journal of Biological Engineering, Vol 12, Iss 1, Pp 1-15 (2018)
Abstract Background Cell-based therapy by transplantation of nucleus pulposus (NP) progenitor/notochordal cells has been proposed as a promising way to halt and reverse the progression of disc degeneration. Although some studies have provided a broad
Externí odkaz:
https://doaj.org/article/2ada085b6fb2498eb7ad327a52e48b87