Zobrazeno 1 - 10
of 1 970
pro vyhledávání: '"notch pathway"'
Autor:
Da Kang, Shanshan Huang, Yijun Liao, Siyuan Mi, Jingying Zhou, Yu Feng, Riming Huang, Zhen-hai Lu, Z. Z. Pan, Wenjuan Ma, Gong Chen, Jia-Xing Yue, Jingxiu Huang, R. X. Zhang
Publikováno v:
Journal of Translational Medicine, Vol 22, Iss 1, Pp 1-19 (2024)
Abstract Background LARC patients commonly receive adjuvant therapy, however, hidden micrometastases still limit the improvement of OS. This study aims to investigate the impact of VASN in rectal cancer with pulmonary metastasis and understand the un
Externí odkaz:
https://doaj.org/article/18764969a3ff4f9aa6c2d00074ff9741
Autor:
Nour Sfeir, Marilyn Kajdan, Stéphan Jalaguier, Sandrine Bonnet, Catherine Teyssier, Samuel Pyrdziak, Rong Yuan, Emilie Bousquet, Antonio Maraver, Florence Bernex, Nelly Pirot, Florence Boissière‐Michot, Audrey Castet‐Nicolas, Marion Lapierre, Vincent Cavaillès
Publikováno v:
Molecular Oncology, Vol 18, Iss 6, Pp 1510-1530 (2024)
The transcription factor receptor‐interacting protein 140 (RIP140) regulates intestinal homeostasis and tumorigenesis through Wnt signaling. In this study, we investigated its effect on the Notch/HES1 signaling pathway. In colorectal cancer (CRC) c
Externí odkaz:
https://doaj.org/article/ef62a18970854d809d547ebde1121c5e
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 57, Iss , Pp 101041- (2024)
The activation of the Notch pathway promotes the occurrence and progression of breast cancer. The Notch signal plays different roles in different molecular subtypes of breast cancer. In estrogen receptor-positive (ER+) breast cancer, the Notch pathwa
Externí odkaz:
https://doaj.org/article/8adbf8e4a83442dab4ae701daa40e8d1
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 19, Iss 1, Pp 101417- (2025)
Background & Aims: Notch and TAZ are implicated in cholangiocarcinogenesis, but whether and how these oncogenic molecules interact remain unknown. Methods: The development of cholangiocarcinoma (CCA) was induced by hydrodynamic tail vein injection of
Externí odkaz:
https://doaj.org/article/e54336ad24ef4e868c31a1ed294b7dab
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
ObjectiveVitamin D/Vitamin D receptor (VD/VDR) signaling and the Notch pathway are involved in intestinal barrier restoration in colitis; however, their relationship and underlying mechanism are largely unknown. Therefore, this study aimed to investi
Externí odkaz:
https://doaj.org/article/22b5d6abceb64c1aa6b51e1f443df503
Publikováno v:
Central European Journal of Immunology, Vol 48, Iss 4, Pp 274-289 (2024)
Externí odkaz:
https://doaj.org/article/138bbb685add45ddb33a7e077c075ea3
Publikováno v:
Poultry Science, Vol 103, Iss 1, Pp 103171- (2024)
ABSTRACT: Vaccination is still the main method of preventing most infectious diseases, but there are inefficiencies and inaccuracies in immunization. Studies have reported that Atractylodis macrocephalae Koidz. polysaccharides (RAMP) have immunomodul
Externí odkaz:
https://doaj.org/article/ef12201440e24fee95a097ea6fc92b3c
Publikováno v:
Heliyon, Vol 9, Iss 12, Pp e22087- (2023)
Objectives: Cholangiocarcinoma (CHOL) is a malignant tumor from extrahepatic bile duct with poor prognosis. The critical roles of long non-coding RNAs (lncRNAs) in cancers including CHOL have been unveiled in recent decades. The present study was aim
Externí odkaz:
https://doaj.org/article/a536186eb3f24220a58c204f59416c94
Autor:
Magda M. F. Ismail, Rehab R. El-Awady, Amal M. Farrag, Sara H. Mahmoud, Noura M. Abo Shama, Ahmed Mostafa, Mohamed A. Ali, Mohammed H. Rashed, Iman H. Ibrahim
Publikováno v:
Journal of Genetic Engineering and Biotechnology, Vol 21, Iss 1, Pp 1-10 (2023)
Abstract Background SARS-CoV-2 infection involves disturbing multiple molecular pathways related to immunity and cellular functions. PIM1 is a serine/threonine-protein kinase found to be involved in the pathogenesis of several viral infections. One P
Externí odkaz:
https://doaj.org/article/793fc42dc81f4b0a80aa4ec8ebb7d90e
Autor:
Hassan Yousefi, Afshin Bahramy, Narges Zafari, Mahsa Rostamian Delavar, Khoa Nguyen, Atousa Haghi, Tahmineh Kandelouei, Cecilia Vittori, Parham Jazireian, Sajad Maleki, Danyal Imani, Amin Moshksar, Amirreza Bitaraf, Sadegh Babashah
Publikováno v:
BMC Cancer, Vol 22, Iss 1, Pp 1-21 (2022)
Abstract Breast cancer is a complex disease exhibiting a great degree of heterogeneity due to different molecular subtypes. Notch signaling regulates the differentiation of breast epithelial cells during normal development and plays a crucial role in
Externí odkaz:
https://doaj.org/article/0ae73e25bf964666a4a44040a63225dd