Zobrazeno 1 - 10
of 1 290
pro vyhledávání: '"normal cell"'
Publikováno v:
Journal of Mazandaran University of Medical Sciences, Vol 33, Iss 220, Pp 187-193 (2023)
Background and purpose: In clinical treatment of cancer, improving the efficacy of drugs and targeted drug delivery have always been a fundamental problem requiring more focused solutions. The purpose of this study was to investigate the protective e
Externí odkaz:
https://doaj.org/article/6d1c34c571294ba8b81221c8fb4f830f
Autor:
James C. L. Chow, Harry E. Ruda
Publikováno v:
Cells, Vol 13, Iss 10, p 835 (2024)
The advent of FLASH radiotherapy (FLASH-RT) has brought forth a paradigm shift in cancer treatment, showcasing remarkable normal cell sparing effects with ultra-high dose rates (>40 Gy/s). This review delves into the multifaceted mechanisms underpinn
Externí odkaz:
https://doaj.org/article/6f766b3f336240639879f79d77eb9852
Autor:
Dale M. Walker, Tsvetelina I. Lazarova, Steven W. Riesinger, Miriam C. Poirier, Terri Messier, Brian Cunniff, Vernon E. Walker
Publikováno v:
Frontiers in Oncology, Vol 13 (2023)
The lack of anticancer agents that overcome innate/acquired drug resistance is the single biggest barrier to achieving a durable complete response to cancer therapy. To address this issue, a new drug family was developed for intracellular delivery of
Externí odkaz:
https://doaj.org/article/f4c45ff1604b44f9a8e00b84babc041b
Autor:
Ahmed El-Sayed Abdelhamid, Ahmed El-Sayed, Samira A. Swelam, Abdelmohsen M. Soliman, Ahmed M. Khalil
Publikováno v:
ADMET and DMPK (2023)
Background and purpose: Polycaprolactone nanocapsules incorporated with triazole derivatives in the presence and absence of selenium nanoparticles were prepared and evaluated as antiproliferative and anticancer agents. Polycaprolactone nanoparticle
Externí odkaz:
https://doaj.org/article/72c8856cc6254706bfabf8105e0fc90e
Autor:
Eslaminejad Touba, Pourshojaei Yaghoub, Naghizadeh Mahmood, Eslami Hoda, Daneshpajouh Mohammad, Hassanzadeh Abdolreza
Publikováno v:
Journal of the Serbian Chemical Society, Vol 87, Iss 10, Pp 1125-1142 (2022)
Iron homeostasis is altered in tumours in response to a perturbation in the expression of iron-dependent proteins. Therefore, iron chelators make cancerous cells more vulnerable to iron deficiency. Compounds having thiosemicarbazide scaffold with the
Externí odkaz:
https://doaj.org/article/26bb327c054248ee8a8fac8194e90736
Autor:
Purnama, Kindi Farabi, Dudi Runadi, Hadi Kuncoro, Desi Harneti, Nurlelasari, Tri Mayanti, Mohamad Nurul Azmi, Sofa Fajriah, Unang Supratman
Publikováno v:
Molecules, Vol 28, Iss 13, p 4946 (2023)
The Aglaia genus, a member of the Meliaceae family, is generally recognized to include a number of secondary metabolite compounds with diverse structures and biological activities, including triterpenoids. Among the members of this genus, Aglaia cucu
Externí odkaz:
https://doaj.org/article/7a215679f53c46bfadab65d139f0f79c
Publikováno v:
International Journal of Mathematical, Engineering and Management Sciences, Vol 5, Iss 6, Pp 1392-1408 (2020)
In this paper, we present a two-stage stochastic model of carcinogenesis in a two level random environment. The random environment switches between two levels, say, 1 and 2 alternately. When the environment is in level 1, a normal cell either divides
Externí odkaz:
https://doaj.org/article/edd3e20afabe4ce8bac4a651f4e80a3e
Publikováno v:
International Journal of Mathematical, Engineering and Management Sciences, Vol 5, Iss 6, Pp 1468-1487 (2020)
A two-mutation model of carcinogenesis which evolves under the influence of three level random environment on the production process is formulated and analyzed. A random environment occupies one of the levels 1, 2 and 3 at any time t according to a M
Externí odkaz:
https://doaj.org/article/63b9222abdfd4a66b89cf92ffcbb1f59
Publikováno v:
Molecules, Vol 28, Iss 7, p 2907 (2023)
Standard therapies for colorectal cancer cannot eliminate or sufficiently reduce the metastasis process. Photodynamic therapy (PDT) may be an alternative to minimizing this problem. Here, we examined the cellular localization of selected porphyrins a
Externí odkaz:
https://doaj.org/article/d37bc7a912f64fb79062accf981f9250
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