Zobrazeno 1 - 10
of 35
pro vyhledávání: '"norbaeocystin"'
Publikováno v:
PeerJ, Vol 12, p e17517 (2024)
Background Psilocybin and related tryptamines have come into the spotlight in recent years as potential therapeutics for depression. Research on the mechanisms of these effects has historically focused on the direct effects of these drugs on neural p
Externí odkaz:
https://doaj.org/article/9b88047683704a309825f11d02456fb9
Akademický článek
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Autor:
Alexandra M. Adams, Nicholas A. Anas, Abhishek K. Sen, Jordan D. Hinegardner-Hendricks, Philip J. O’Dell, William J. Gibbons, Jr., Jessica E. Flower, Matthew S. McMurray, J. Andrew Jones
Publikováno v:
Metabolic Engineering Communications, Vol 14, Iss , Pp e00196- (2022)
Interest in the potential therapeutic efficacy of psilocybin and other psychedelic compounds has escalated significantly in recent years. To date, little is known regarding the biological activity of the psilocybin pathway intermediate, norbaeocystin
Externí odkaz:
https://doaj.org/article/8618c3a378634ed5a5a5fbbbc8f123f5
Akademický článek
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Autor:
Sandoval, Oscar
Clinical trials on the use of psilocybin to treat depression are promising but are confounded by the presence of hallucinations which may not be necessary for effectiveness. Preliminary data suggests that when administered to rats, related tryptamine
Autor:
McKinney, Madeline Gray
Clinical evaluation of psilocybin, a hallucinogen found in “magic mushrooms,” as treatment for severe depression and addiction is ongoing. Our enzymatic pathway to production of psilocybin involves norbaeocystin methyltransferase (PsiM), responsi
Autor:
O'Dell, Philip John
Microbial platforms as a means of chemical production present a cost effective, environmentally friendly, and dynamic strategy for the synthesis of biofuels, pharmaceuticals, and food products. Most bacterial chemical production platforms utilize pla
Autor:
Anas, Nicholas Alexander
Psilocybin has come into the spotlight in recent years as a potential therapeutic for long-lasting anxiety and depression relief. Unfortunately, due to its current classification as a schedule I substance research on it has been limited. In order to
Autor:
Adam L. Halberstadt, Robert B. Kargbo, Alexander M. Sherwood, Poncho Meisenheimer, Kristi W. Kaylo, Adam K. Klein, John D. McCorvy
Publikováno v:
Journal of Natural Products. 83:461-467
A general synthetic method was developed to access known tryptamine natural products present in psilocybin-producing mushrooms. In vitro and in vivo experiments were then conducted to inform speculations on the psychoactive properties, or lack thereo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa9de7705e48582ab0e906cd5e38ec5c
https://doi.org/10.1021/acs.jnatprod.9b01061
https://doi.org/10.1021/acs.jnatprod.9b01061
Autor:
John D. Brinton, Chantal S. Monnier, Alexis L. Enacopol, Alexandra M. Adams, J. Andrew Jones, Nicholas A. Kaplan, Zhangyue Wei, Theresa Ramelot
Publikováno v:
Metabolic Engineering. 56:111-119
Psilocybin, the prodrug of the psychoactive molecule psilocin, has demonstrated promising results in clinical trials for the treatment of addiction, depression, and post-traumatic stress disorder. The development of a psilocybin production platform i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db9436389012def2794408337c636e25
https://doi.org/10.1016/j.ymben.2019.09.009
https://doi.org/10.1016/j.ymben.2019.09.009