Zobrazeno 1 - 10
of 789
pro vyhledávání: '"non-obese diabetic"'
Autor:
Marie-Andrée Bessard, Anna Moser, Emmanuelle Waeckel-Énée, Vivian Lindo, Abdelaziz Gdoura, Sylvaine You, F. Susan Wong, Fiona Greer, Peter van Endert
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
Type 1 diabetes results from the destruction of pancreatic beta cells by autoreactive T cells. As an autoantigen with extremely high expression in beta cells, insulin triggers and sustains the autoimmune CD4+ and CD8+ T cell responses and islet infla
Externí odkaz:
https://doaj.org/article/4493069f3b8a4b9f9080e9bef49ca1c2
Publikováno v:
FEBS Open Bio, Vol 14, Iss 3, Pp 434-443 (2024)
Type 1 diabetes (T1D) is an autoimmune disease initiated by genetic predisposition and environmental influences, which result in the specific destruction of insulin‐producing pancreatic β‐cells. Currently, there are over 1.6 million cases of T1D
Externí odkaz:
https://doaj.org/article/1211d3c5ecbf4a9fac4cb6421c0b3831
Publikováno v:
Jichu yixue yu linchuang, Vol 43, Iss 1, Pp 59-67 (2023)
Objective To explore a newly discovered T cell antigen [the group-specific antigen(Gag)of endogenous retrovirus (ERV)] associated with type 1 diabetes (T1D) and the pathogenesis of T1D. Methods First, to analyze the amino acid sequence of an islet-ex
Externí odkaz:
https://doaj.org/article/629a1330c6574d02b15a8aa1489add4b
Autor:
Camilla Hartmann Friis Hansen, Martin Haupt‐Jorgensen, Karsten Buschard, Bente Pakkenberg, Lukasz Krych, Axel Kornerup Hansen
Publikováno v:
Clinical and Translational Discovery, Vol 3, Iss 2, Pp n/a-n/a (2023)
Abstract Background Early antibiotic treatment changes susceptibility to disease in rodent models for type 1 diabetes, but the impact that gestational antibiotics may have on pancreatic embryogenesis and β cell function later in life is still unknow
Externí odkaz:
https://doaj.org/article/863784c01dfa40cab2ace2c2a46937e8
Autor:
James A. Pearson, Jian Peng, Juan Huang, Xiaoqing Yu, Ningwen Tai, Youjia Hu, Sha Sha, Richard A. Flavell, Hongyu Zhao, F. Susan Wong, Li Wen
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
IntroductionGut microbiota have been linked to modulating susceptibility to Type 1 diabetes; however, there are many ways in which the microbiota interact with host cells, including through microbial ligand binding to intracellular inflammasomes (lar
Externí odkaz:
https://doaj.org/article/e81605a24c0f43b481c0a75c772edb75
Akademický článek
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Autor:
Lucienne Chatenoud, Cindy Marquet, Fabrice Valette, Lindsay Scott, Jiexia Quan, Chun Hui Bu, Sara Hildebrand, Eva Marie Y. Moresco, Jean-François Bach, Bruce Beutler
Publikováno v:
Disease Models & Mechanisms, Vol 15, Iss 6 (2022)
Genetic association studies of type 1 diabetes (T1D) in humans, and in congenic non-obese diabetic (NOD) mice harboring DNA segments from T1D-resistant mice, face the challenge of assigning causation to specific gene variants among many within loci t
Externí odkaz:
https://doaj.org/article/8f1693213fcf42edb01f31ae9b26c371
Autor:
Somayeh Alsadat Hosseini Khorami, Mohd Sokhini Abd Mutalib, Mohammad Feili Shiraz, Joseph Anthony Abdullah, Zulida Rejali, Razana Mohd Ali, Huzwah Khaza’ai
Publikováno v:
Nutrition & Metabolism, Vol 17, Iss 1, Pp 1-9 (2020)
Abstract Background Although obesity is considered as the main cause of Type II diabetes (T2DM), non-obese individuals may still develop T2DM and obese individuals may not. Method The mRNA expression of PI3K/AKT axis from 100 non-obese and obese part
Externí odkaz:
https://doaj.org/article/5924837bd33b4942a7dc861d102c4655
Publikováno v:
Nutrition & Metabolism, Vol 16, Iss 1, Pp 1-15 (2019)
Abstract Background This study was to investigate the effect and its possible mechanism of fucoidan on the development of spontaneous autoimmune diabetes in non-obese diabetic (NOD) mice. Methods 7-week-old NOD mice were randomly divided into three g
Externí odkaz:
https://doaj.org/article/e14fff56ad0a42ec9ba4be3bc9b9cc75
Akademický článek
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