Zobrazeno 1 - 10
of 75
pro vyhledávání: '"non-coding mutations"'
Autor:
Royce W. Zhou, Ramon E. Parsons
Publikováno v:
Epigenetics & Chromatin, Vol 16, Iss 1, Pp 1-14 (2023)
Abstract Super-enhancers are large, densely concentrated swaths of enhancers that regulate genes critical for cell identity. Tumorigenesis is accompanied by changes in the super-enhancer landscape. These aberrant super-enhancers commonly form to acti
Externí odkaz:
https://doaj.org/article/5945cbf249024215bd23331f041573f5
Autor:
Niantao Deng, Andre Minoche, Kate Harvey, Meng Li, Juliane Winkler, Andrei Goga, Alex Swarbrick
Publikováno v:
Breast Cancer Research, Vol 24, Iss 1, Pp 1-12 (2022)
Abstract Background Breast cancer cell lines (BCCLs) and patient-derived xenografts (PDXs) are the most frequently used models in breast cancer research. Despite their widespread usage, genome sequencing of these models is incomplete, with previous s
Externí odkaz:
https://doaj.org/article/10b7803de6574e2a900f1190e872c4f4
Autor:
Chia-Chi Flora Huang, Shreyas Lingadahalli, Tunc Morova, Dogancan Ozturan, Eugene Hu, Ivan Pak Lok Yu, Simon Linder, Marlous Hoogstraat, Suzan Stelloo, Funda Sar, Henk van der Poel, Umut Berkay Altintas, Mohammadali Saffarzadeh, Stephane Le Bihan, Brian McConeghy, Bengul Gokbayrak, Felix Y. Feng, Martin E. Gleave, Andries M. Bergman, Colin Collins, Faraz Hach, Wilbert Zwart, Eldon Emberly, Nathan A. Lack
Publikováno v:
Genome Biology, Vol 22, Iss 1, Pp 1-26 (2021)
Abstract Background Androgen receptor (AR) is critical to the initiation, growth, and progression of prostate cancer. Once activated, the AR binds to cis-regulatory enhancer elements on DNA that drive gene expression. Yet, there are 10–100× more b
Externí odkaz:
https://doaj.org/article/f44c462b807b4890bf2fd42d2752fc95
Autor:
Omar Soukarieh, Caroline Meguerditchian, Carole Proust, Dylan Aïssi, Mélanie Eyries, Aurélie Goyenvalle, David-Alexandre Trégouët
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 9 (2022)
High-throughput sequencing (HTS) technologies are revolutionizing the research and molecular diagnosis landscape by allowing the exploration of millions of nucleotide sequences at an unprecedented scale. These technologies are of particular interest
Externí odkaz:
https://doaj.org/article/855c4ba593564fb58cf7a3e3fbf52c62
Publikováno v:
Frontiers in Genetics, Vol 10 (2019)
Most of somatic mutations in cancer occur outside of gene coding regions. These mutations may disrupt the gene regulation by affecting protein-DNA interaction. A study of these disruptions is important in understanding tumorigenesis. However, current
Externí odkaz:
https://doaj.org/article/e436110b215e4be89699cae203aeade0
Akademický článek
Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.
K zobrazení výsledku je třeba se přihlásit.
Akademický článek
Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.
K zobrazení výsledku je třeba se přihlásit.
Autor:
Malene Juul, Johanna Bertl, Qianyun Guo, Morten Muhlig Nielsen, Michał Świtnicki, Henrik Hornshøj, Tobias Madsen, Asger Hobolth, Jakob Skou Pedersen
Publikováno v:
eLife, Vol 6 (2017)
Non-coding mutations may drive cancer development. Statistical detection of non-coding driver regions is challenged by a varying mutation rate and uncertainty of functional impact. Here, we develop a statistically founded non-coding driver-detection
Externí odkaz:
https://doaj.org/article/54aad4714b7543518be768b65cd9b8f8
Autor:
Irene Miguel-Escalada, Miguel Ángel Maestro, Diego Balboa, Anamaria Elek, Aina Bernal, Edgar Bernardo, Vanessa Grau, Javier García-Hurtado, Arnau Sebé-Pedrós, Jorge Ferrer
Publikováno v:
1936.e9
Sequence variants in cis-acting enhancers are important for polygenic disease, but their role in Mendelian disease is poorly understood. Redundancy between enhancers that regulate the same gene is thought to mitigate the pathogenic impact of enhancer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5f260ed7f7c570b494b454ba594bb83
http://hdl.handle.net/10044/1/99332
http://hdl.handle.net/10044/1/99332
Autor:
Ewelina Bukowska-Olech, Robert Schöpflin, Verena Heinrich, Magdalena Socha, Martin Franke, Varun K. A. Sreenivasan, Uirá Souto Melo, Inga Nagel, Cristina López, Aleksander Jamsheer, Martin Vingron, Anna Sowińska-Seidler, Stefan Mundlos, Nicolas Gruchy, Bjørt K Kragesteen, Malte Spielmann
Publikováno v:
American Journal of Human Genetics
American Journal of Human Genetics, Elsevier (Cell Press), 2021, 108 (9), pp.1725-1734. ⟨10.1016/j.ajhg.2021.08.001⟩
Am J Hum Genet
Digital.CSIC. Repositorio Institucional del CSIC
instname
The American Journal of Human Genetics
American Journal of Human Genetics, Elsevier (Cell Press), 2021, 108 (9), pp.1725-1734. ⟨10.1016/j.ajhg.2021.08.001⟩
Am J Hum Genet
Digital.CSIC. Repositorio Institucional del CSIC
instname
The American Journal of Human Genetics
Copy-number variations (CNVs) are a common cause of congenital limb malformations and are interpreted primarily on the basis of their effect on gene dosage. However, recent studies show that CNVs also influence the 3D genome chromatin organization. T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6c08a1a10d20ce527ff7c6de3d5fe37
https://hal-normandie-univ.archives-ouvertes.fr/hal-03351770
https://hal-normandie-univ.archives-ouvertes.fr/hal-03351770