Zobrazeno 1 - 10
of 177
pro vyhledávání: '"non-coding genome"'
Publikováno v:
Genome Biology, Vol 25, Iss 1, Pp 1-21 (2024)
Abstract Background Genome-wide association studies (GWAS) have revealed a multitude of candidate genetic variants affecting the risk of developing complex traits and diseases. However, the highlighted regions are typically in the non-coding genome,
Externí odkaz:
https://doaj.org/article/099398ad9e2c40298c05b0f4e4c6d0c5
Autor:
Gherman Luciana-Mădălina, Isachesku Ekaterina, Zanoaga Oana, Braicu Cornelia, Berindan-Neagoe Ioana
Publikováno v:
Acta Veterinaria, Vol 74, Iss 2, Pp 159-182 (2024)
Canine mammary tumors (CMTs) are one of the most common neoplasms in female dogs. Unfortunately, the current diagnosis often occurs in later stages, and there is a pressing need for more comprehensive data on treatment options to improve overall prog
Externí odkaz:
https://doaj.org/article/d596348b88024a2a9a77d7a85441e7bf
Publikováno v:
BMC Medical Genomics, Vol 16, Iss 1, Pp 1-3 (2023)
Abstract Histone deacetylase (HDAC) inhibitors have enormous therapeutic potential as effective epigenetic regulators, and now with the focus on the selective HDAC6 inhibitor in ongoing clinical trials, more advantages over other non-selective pan-HD
Externí odkaz:
https://doaj.org/article/7d4d7f0ce3454888a1db76ee22921bec
Akademický článek
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Autor:
Hanna K. Zieger, Leonie Weinhold, Axel Schmidt, Manuel Holtgrewe, Stefan A. Juranek, Anna Siewert, Annika B. Scheer, Frederic Thieme, Elisabeth Mangold, Nina Ishorst, Fabian U. Brand, Julia Welzenbach, Dieter Beule, Katrin Paeschke, Peter M. Krawitz, Kerstin U. Ludwig
Publikováno v:
HGG Advances, Vol 4, Iss 1, Pp 100166- (2023)
Summary: Non-syndromic cleft lip with/without cleft palate (nsCL/P) is a highly heritable facial disorder. To date, systematic investigations of the contribution of rare variants in non-coding regions to nsCL/P etiology are sparse. Here, we re-analyz
Externí odkaz:
https://doaj.org/article/b61b5dc4116e41ea98f08ed8d964fc18
Akademický článek
Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.
K zobrazení výsledku je třeba se přihlásit.
Autor:
Soheil Yousefi, Ruizhi Deng, Kristina Lanko, Eva Medico Salsench, Anita Nikoncuk, Herma C. van der Linde, Elena Perenthaler, Tjakko J. van Ham, Eskeatnaf Mulugeta, Tahsin Stefan Barakat
Publikováno v:
Genome Medicine, Vol 13, Iss 1, Pp 1-27 (2021)
Abstract Background Non-coding regulatory elements (NCREs), such as enhancers, play a crucial role in gene regulation, and genetic aberrations in NCREs can lead to human disease, including brain disorders. The human brain is a complex organ that is s
Externí odkaz:
https://doaj.org/article/8bd08f49ac6c42ddbc775328a55f61d6
Autor:
Santosh Kumar, Valid Gahramanov, Shivani Patel, Julia Yaglom, Lukasz Kaczmarczyk, Ivan A. Alexandrov, Gabi Gerlitz, Mali Salmon-Divon, Michael Y. Sherman
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 10, p 8717 (2023)
Resistance to chemotherapy is a leading cause of treatment failure. Drug resistance mechanisms involve mutations in specific proteins or changes in their expression levels. It is commonly understood that resistance mutations happen randomly prior to
Externí odkaz:
https://doaj.org/article/d91ea360a5f6405ea4e6111d3125d0ca
Autor:
Yasmeen Niazi, Nagarajan Paramasivam, Joanna Blocka, Abhishek Kumar, Stefanie Huhn, Matthias Schlesner, Niels Weinhold, Rolf Sijmons, Mirjam De Jong, Brian Durie, Hartmut Goldschmidt, Kari Hemminki, Asta Försti
Publikováno v:
Cells, Vol 12, Iss 1, p 96 (2022)
Multiple myeloma (MM) is a plasma cell malignancy whereby a single clone of plasma cells over-propagates in the bone marrow, resulting in the increased production of monoclonal immunoglobulin. While the complex genetic architecture of MM is well char
Externí odkaz:
https://doaj.org/article/8dfdcdca7e404162a990008cf2fcebd3
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
Although long non-coding RNAs (lncRNAs) is one of the most abundant classes of RNAs encoded within the mammalian genome and are highly expressed in the adult brain, they remain poorly characterized and their roles in the brain development are not wel
Externí odkaz:
https://doaj.org/article/5d48f80597be4c68bc8a75e68059c01e