Zobrazeno 1 - 10
of 797
pro vyhledávání: '"non-ATP competitive inhibitor"'
Autor:
Gumireddy, Kiranmai, Baker, Stacey J., Cosenza, Stephen C., John, Premila, Kang, Anthony D., Robell, Kimberly A., Reddy, E. Premkumar, Vogt, Peter K.
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America, 2005 Feb 01. 102(6), 1992-1997.
Externí odkaz:
https://www.jstor.org/stable/3374550
Akademický článek
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Autor:
Gracia Porras, Claudia Gonzalo-Consuegra, Ángeles Martín-Requero, Eva de Lago, Loreto Martínez-González, Marta Gómez-Almería, Ana Martínez
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 8975, p 8975 (2021)
International Journal of Molecular Sciences
Volume 22
Issue 16
E-Prints Complutense. Archivo Institucional de la UCM
instname
Digital.CSIC. Repositorio Institucional del CSIC
International Journal of Molecular Sciences
Volume 22
Issue 16
E-Prints Complutense. Archivo Institucional de la UCM
instname
Digital.CSIC. Repositorio Institucional del CSIC
14 p.-6 fig.-2 tab.
Amyotrophic Lateral Sclerosis (ALS) is the most common degenerative motor neuron disease in adults. About 97% of ALS patients present TDP-43 aggregates with post-translational modifications, such as hyperphosphorylation, in t
Amyotrophic Lateral Sclerosis (ALS) is the most common degenerative motor neuron disease in adults. About 97% of ALS patients present TDP-43 aggregates with post-translational modifications, such as hyperphosphorylation, in t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::119cf6e8bee24d514c63ee7f7febc373
https://www.mdpi.com/1422-0067/22/16/8975
https://www.mdpi.com/1422-0067/22/16/8975
Publikováno v:
Pharmaceutical Fronts, Vol 06, Iss 03, Pp e195-e220 (2024)
Cyclin-dependent kinase 2 (CDK2) is a critical regulator of cell division and has emerged as a promising target for anticancer treatment. In this article, we summarize the structural features of CDK2 inhibitors and corresponding binding modes, in par
Externí odkaz:
https://doaj.org/article/e5b049d433b94916af50432267275997
Akademický článek
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Publikováno v:
Biochemistry; 2/6/2007, Vol. 46 Issue 5, p1358-1367, 10p, 4 Charts, 1 Graph
Publikováno v:
The Oncologist. 16:788-799
Expression of the receptor tyrosine kinase c-MET (MET, mesenchymal-epithelial transition factor) in many cancers, and its participation in multiple signal transduction pathways involved in malignant tumor growth, suggest a wide therapeutic potential
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b512a68e9ba98769342833f73d0275a
https://doi.org/10.1634/theoncologist.2010-0380
https://doi.org/10.1634/theoncologist.2010-0380
Autor:
Stacey J. Baker, E. Premkumar Reddy, Stephen C. Cosenza, Kiranmai Gumireddy, Anthony D. Kang, Premila John, Kimberly A. Robell, M. V. Ramana Reddy
Publikováno v:
Proceedings of the National Academy of Sciences. 102:1992-1997
Imatinib, which is an inhibitor of the BCR-ABL tyrosine kinase, has been a remarkable success for the treatment of Philadelphia chromosome-positive (Ph + ) chronic myelogenous leukemias (CMLs). However, a significant proportion of patients chronicall
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08d2b3cdcf2c9afbcbafa02eac2b6bfc
https://doi.org/10.1073/pnas.0408283102
https://doi.org/10.1073/pnas.0408283102
Autor:
Catherine K. Smith, William T. Windsor
Publikováno v:
Biochemistry. 46(5)
MEK1 is a member of the MAPK signal transduction pathway that responds to growth factors and cytokines. A wealth of information about the enzymatic activity of MEK1, its domain functions, and inhibitor action is available; however, the thermodynamic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9683e3ac027652313dab696e562090a
https://pubmed.ncbi.nlm.nih.gov/17260965
https://pubmed.ncbi.nlm.nih.gov/17260965