Výsledky vyhledávání - "nitro-oleic acid"

Akademický článek

Nitro-oleic acid ameliorates erectile dysfunction in a streptozotocin-induced rat model of diabetes by inhibiting oxidative stress and apoptosis and activating the NO/cGMP pathway

Autor: Chang-Bo Zhao, Wei-Bo Chen, Wen-Zhen Wang, Fang-Xin Gong, Cui-Qin Fan, Ye Li, Tian Lan, Wen-Jing Wang, Ming-Zhen Yuan

Publikováno v: Asian Journal of Andrology, Vol 26, Iss 1, Pp 57-66 (2024)

The major vascular complications associated with diabetes make the management of diabetic mellitus erectile dysfunction (DMED) a challenging endeavor. Notable factors contributing to DMED include oxidative stress, nitric oxide (NO)/cyclic guanosine m

Externí odkaz: https://doaj.org/article/caf6561ffabe4d8fa7a9e51167527bca

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Electrophilic nitro-fatty acids suppress psoriasiform dermatitis: STAT3 inhibition as a contributory mechanism

Autor: Peng Wang, Meaghan E. Killeen, Tina L. Sumpter, Laura K. Ferris, Louis D. Falo, Jr., Bruce A. Freeman, Francisco J. Schopfer, Alicia R. Mathers

Publikováno v: Redox Biology, Vol 43, Iss , Pp 101987- (2021)

Psoriasis is a chronic inflammatory skin disease with no cure. Although the origin of psoriasis and its underlying pathophysiology remain incompletely understood, inflammation is a central mediator of disease progression. In this regard, electrophili

Externí odkaz: https://doaj.org/article/4b0d7cf207144e3e87124caa4fa7109b

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Akademický článek

TRP Channel Agonists Activate Different Afferent Neuromodulatory Mechanisms in Guinea Pig Urinary Bladder

Autor: Stephanie L. Daugherty, Jonathan M. Beckel, Kyoungeun A. Kim, Bruce A. Freeman, Jiaxin Liu, Shaoyong Wang, William C. de Groat, Xiulin Zhang

Publikováno v: Frontiers in Physiology, Vol 12 (2021)

Activation of TRP channels expressed in urinary bladder afferent nerves and urothelium releases neurotransmitters that influence bladder function. Experiments were undertaken to examine the mechanisms underlying effects of TRPA1 (allyl isothiocyanate

Externí odkaz: https://doaj.org/article/06b4a14dbd334bba8ae0608b28b63a92

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Akademický článek

Electrophilic fatty acid nitroalkenes are systemically transported and distributed upon esterification to complex lipids[S]

Autor: Marco Fazzari, Dario A. Vitturi, Steven R. Woodcock, Sonia R. Salvatore, Bruce A. Freeman, Francisco J. Schopfer

Publikováno v: Journal of Lipid Research, Vol 60, Iss 2, Pp 388-399 (2019)

Electrophilic nitro-fatty acids [NO2-FAs (fatty acid nitroalkenes)] showed beneficial signaling actions in preclinical studies and safety in phase 1 clinical trials. A detailed description of the pharmacokinetics (PK) of NO2-FAs is complicated by the

Externí odkaz: https://doaj.org/article/b7f8eccab07f43aab87326995af65349

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Akademický článek

Nitro-Oleic Acid-Mediated Nitroalkylation Modulates the Antioxidant Function of Cytosolic Peroxiredoxin Tsa1 during Heat Stress in Saccharomyces cerevisiae

Autor: Lorena Aranda-Caño, Raquel Valderrama, José Rafael Pedrajas, Juan C. Begara-Morales, Mounira Chaki, María N. Padilla, Manuel Melguizo, Francisco Javier López-Jaramillo, Juan B. Barroso

Publikováno v: Antioxidants, Vol 11, Iss 5, p 972 (2022)

Heat stress is one of the abiotic stresses that leads to oxidative stress. To protect themselves, yeast cells activate the antioxidant response, in which cytosolic peroxiredoxin Tsa1 plays an important role in hydrogen peroxide removal. Concomitantly

Externí odkaz: https://doaj.org/article/5541e693bdef4d46b9e2668900f0e470

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Nitro-oleic acid, a ligand of CD36, reduces cholesterol accumulation by modulating oxidized-LDL uptake and cholesterol efflux in RAW264.7 macrophages

Autor: Matias M. Vazquez, Maria V. Gutierrez, Sonia R. Salvatore, Marcelo Puiatti, Virginia Actis Dato, Gustavo A. Chiabrando, Bruce A. Freeman, Francisco J. Schopfer, Gustavo Bonacci

Publikováno v: Redox Biology, Vol 36, Iss , Pp 101591- (2020)

Macrophages play a pivotal role in the early stages of atherosclerosis development; they excessively accumulate cholesterol in the cytosol in response to modified Low Density Lipoprotein (mLDL). The mLDL are incorporated through scavenger receptors.

Externí odkaz: https://doaj.org/article/696abec26e4f46858c34f1e821492269

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Akademický článek

Exogenous Nitro-Oleic Acid Treatment Inhibits Primary Root Growth by Reducing the Mitosis in the Meristem in Arabidopsis thaliana

Autor: Luciano M. Di Fino, Ignacio Cerrudo, Sonia R. Salvatore, Francisco J. Schopfer, Carlos García-Mata, Ana M. Laxalt

Publikováno v: Frontiers in Plant Science, Vol 11 (2020)

Nitric oxide (NO) is a second messenger that regulates a broad range of physiological processes in plants. NO-derived molecules called reactive nitrogen species (RNS) can react with unsaturated fatty acids generating nitrated fatty acids (NO2-FA). NO

Externí odkaz: https://doaj.org/article/b8ecf7d927554b47889623b168ed34e9

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