Zobrazeno 1 - 10
of 573
pro vyhledávání: '"nisoxetine"'
Autor:
Hyomin Ahn, Kichul Park, Dongyoung Kim, Sung-Gil Chi, Kee-Hyun Choi, Seo-Jung Han, Chiman Song
Publikováno v:
Biomedicines, Vol 11, Iss 10, p 2846 (2023)
Monoamine transporters, including dopamine, norepinephrine, and serotonin transporters (DAT, NET, and SERT, respectively), are important therapeutic targets due to their essential roles in the brain. To overcome the slow action of selective monoamine
Externí odkaz:
https://doaj.org/article/994692cf78634bf1a827887f379e9027
Akademický článek
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Publikováno v:
Journal of Basic and Applied Zoology, Vol 82, Iss 1, Pp 1-6 (2021)
Background In the central nervous system of mammals, transporters localized on the presynaptic nerve terminals regulate the reuptake of neurotransmitters. These transporters are selective for a specific neurotransmitter such as dopamine (DA) and nore
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::850d9be6ce93ce5247e0d58b3dd9e541
https://doaj.org/article/eb5cab2fe2564af19b9e6337da5045bf
https://doaj.org/article/eb5cab2fe2564af19b9e6337da5045bf
Autor:
Maria R. Yoder, Jonah C. Short-Miller, Eve Privman Champaloux, Danielle C Wolin, Madelaine E. Denno, Nathan C. Donelson, Jeffrey M. Copeland, Poojan Pyakurel, Subhabrata Sanyal, Chris Burke, B. Jill Venton, Ryan P. Borman, Leah Ostendorf
Publikováno v:
Neuroscience
Recent work indicates a role for RING finger protein 11 (RNF11) in Parkinson disease (PD) pathology, which involves the loss of dopaminergic neurons. However, the role of RNF11 in regulating dopamine neurotransmission has not been studied. In this wo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ebf59de54f67331a1507b6ce4a065406
https://doi.org/10.1016/j.neuroscience.2020.10.021
https://doi.org/10.1016/j.neuroscience.2020.10.021
Autor:
Jay P. McLaughlin, Steven Lin, Yizhi Ma, Michael T. Bardo, Bernadette O'Donovan, Jun Zhu, Matthew J. Strauss, Pavel I. Ortinski, Ziyu Xiao
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 374:241-251
Dysregulation of dopamine neurotransmission has been linked to the development of human immunodeficiency virus (HIV)-associated neurocognitive disorder (HAND). To investigate the mechanisms underlying this phenomenon, this study used an inducible HIV
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6c11992dd510542a503c37c677e08b01
https://doi.org/10.1124/jpet.120.266023
https://doi.org/10.1124/jpet.120.266023
Autor:
Rumi Naono-Nakayama, Yu Miyahara, Ayaka Haruta-Tsukamoto, Yasushi Ishida, Hideki Funahashi, Toshikazu Nishimori
Publikováno v:
European Journal of Pharmacology. 850:118-125
The contribution of serotonin and noradrenaline to the modulation of pruriceptive processing was evaluated by administrating antidepressants or noradrenaline reuptake inhibitors. The pretreatment with milnacipran, a serotonin and noradrenaline reupta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a079f6602a08c815915767d8ced03274
https://doi.org/10.1016/j.ejphar.2019.02.013
https://doi.org/10.1016/j.ejphar.2019.02.013
Autor:
G. Andres Contreras, Arun Anantharam, Adam J. Moeser, Robert Burnett, Nadia Ayala-Lopez, Janice M. Thompson, Maleeha Ahmad, Stephanie W. Watts, David J. Ferland, Emma S. Darios, Kyan Thelen, Alexander Ismail
Publikováno v:
Arteriosclerosis, Thrombosis, and Vascular Biology. 39:188-199
Objective— Perivascular adipose tissue (PVAT) contains an independent adrenergic system that can take up, metabolize, release, and potentially synthesize the vasoactive catecholamine norepinephrine. Norepinephrine has been detected in PVAT, but the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8cf746858fdec4455a6dca7506ab62b
https://doi.org/10.1161/atvbaha.118.311720
https://doi.org/10.1161/atvbaha.118.311720
Autor:
Andrea Rossignoli, Wieke M. van Oostveen, Laura Stucchi, Hubert J. Sijben, Lia Scarabottolo, Adriaan P. IJzerman, Giovanna Maresca, Laura H. Heitman, Peter B. R. Hartog
Publikováno v:
Scientific Reports
Scientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
Scientific Reports, 11. Springer Science and Business Media LLC
Scientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
Scientific Reports, 11. Springer Science and Business Media LLC
The human norepinephrine transporter (NET) is an established drug target for a wide range of psychiatric disorders. Conventional methods that are used to functionally characterize NET inhibitors are based on the use of radiolabeled or fluorescent sub
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a16662e2c607a773ad0de4e14975ea98
https://doi.org/10.1038/s41598-021-91700-7
https://doi.org/10.1038/s41598-021-91700-7
Autor:
Therese Ku, Harald H. Sitte, Gisela Andrea Camacho-Hernandez, Ermanno Valoti, Amy Hauck Newman, Dino Luethi, Daryl A. Guthrie, Gerhard J. Schütz, Deborah Rudin, Andrea Casiraghi, Valentina Straniero
Publikováno v:
RSC Med Chem
The utilization of fluorescent ligands to study the monoamine transporters (MATs) has increased our knowledge of their function and distribution in live cell systems. In this study, we extend SAR for nisoxetine and talopram as parent compounds, to id
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7310ed140f407f6da510164195f190a8
https://europepmc.org/articles/PMC8292982/
https://europepmc.org/articles/PMC8292982/
Autor:
Paola Devoto, Claudia Sagheddu, Michele Santoni, Giovanna Flore, Pierluigi Saba, Marco Pistis, Gian Luigi Gessa
Publikováno v:
Frontiers in Pharmacology, Vol 11 (2020)
Frontiers in Pharmacology
Frontiers in Pharmacology
Previous results indicate that dopamine (DA) release in the medial prefrontal cortex (mPFC) is modified by α2 adrenoceptor- but not D2 DA receptor- agonists and antagonists, suggesting that DA measured by microdialysis in the mPFC originates from no
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1a87c184ed8108c2babf43c26ae186e
https://www.frontiersin.org/article/10.3389/fphar.2020.588160/full
https://www.frontiersin.org/article/10.3389/fphar.2020.588160/full