Allosteric modulation of α4β2* nicotinic acetylcholine receptors: Desformylflustrabromine potentiates antiallodynic response of nicotine in a mouse model of neuropathic pain

Autor: D. Ergun, Wisam Toma, Deniz Bagdas, M.I. Damaj, Marvin K. Schulte, Asti Jackson

Publikováno v: Eur J Pain

BackgroundNeuronal nicotinic acetylcholine receptors (nAChRs) are ligand-gated ion channels. The 42 subtype of nAChRs plays an important role in the mediation of pain and several nicotine-evoked responses. Agonists and partial agonists of 42 nAChRs s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6893fa75c309f10eb00917b9c22e563
https://doi.org/10.1002/ejp.1092

Effect of varenicline on behavioral deficits in a rat model of Parkinson's disease induced by unilateral 6-hydroxydopamine lesion of substantia nigra

Autor: Atsushi Yamauchi, Öznur Açikalin, Izzettin Hatip-Al-Khatib, Funda F. Bölükbaşı Hatip, Yasufumi Kataoka, Ruyal F Tan

Nicotinic acetylcholine receptors (nAChRs) are implicated in the pathogenesis of Parkinson's disease (PD). Varenicline tartrate is a partial agonist at ?4ß2 and full agonist at ?7 neuronal nAChR subunits. A unilateral lesion of the substantia nigra

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8732f5c1fc8d08e5e7cf9cb229d499d1
http://acikerisim.pau.edu.tr:8080/xmlui/handle/11499/10973

Transcriptional Regulation of the Novel Monoamine Oxidase Renalase: Crucial Roles of Transcription Factors Sp1, STAT3, and ZBP89

Autor: Ananthamohan Kalyani, Abrar A. Khan, Nitish R. Mahapatra, Binu K. Sasi, Bhargavi Natarajan, Bhavani S. Sahu, Parshuram J. Sonawane, Vinayak Gupta

Publikováno v: Biochemistry. 53:6878-6892

Renalase, a novel monoamine oxidase, is emerging as an important regulator of cardiovascular, metabolic, and renal diseases. However, the mechanism of transcriptional regulation of this enzyme remains largely unknown. We undertook a systematic analys

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74d0fc6d917c882537a36cb913a0e4b2
https://doi.org/10.1021/bi500798n

Effects of methoxsalen, a CYP2A5/6 inhibitor, on nicotine dependence behaviors in mice

Autor: Andy Z. X. Zhu, M. Imad Damaj, Deniz Bagdas, Pretal P. Muldoon, Rachel F. Tyndale

Publikováno v: Neuropharmacology. 85

Metabolism of nicotine to inactive cotinine by hepatic enzyme CYP2A6 is the principal pathway by which active nicotine is removed from circulation. We therefore hypothesized that inhibition of mouse CYP2A5, the ortolog of human CYP2A6, by methoxsalen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c02aafd9f1bd3c5eca53f34e1d9c020
https://pubmed.ncbi.nlm.nih.gov/24859605

α10: A determinant of nicotinic cholinergic receptor function in mammalian vestibular and cochlear mechanosensory hair cells

Autor: Elgoyhen, A.B., Vetter, D.E., Katz, E., Rothlin, C.V., Heinemann, S.F., Boulter, J.

Publikováno v: Proc. Natl. Acad. Sci. U. S. A. 2001;98(6):3501-3506
Biblioteca Digital (UBA-FCEN)
Universidad Nacional de Buenos Aires. Facultad de Ciencias Exactas y Naturales
instacron:UBA-FCEN

We report the cloning and characterization of rat α10, a previously unidentified member of the nicotinic acetylcholine receptor (nAChR) subunit gene family. The protein encoded by the α10 nAChR subunit gene is most similar to the rat α9 nAChR, and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______3056::4eff6d66342b09edba907ce837773ad9