MRE11 is essential for the long‐term viability of undifferentiated spermatogonia.

Autor: Tang, Zhenghui^1,2 (AUTHOR), Liang, Zhongyang^1,2 (AUTHOR), Zhang, Bin^1,2 (AUTHOR), Xu, Xiaohui³ (AUTHOR), Li, Peng^1,4 (AUTHOR), Li, Lejun^1,4,5 (AUTHOR), Lu, Lin‐Yu^1,2,6 (AUTHOR), Liu, Yidan^1,3 (AUTHOR) yidanliu@zju.edu.cn

Publikováno v: Cell Proliferation. Sep2024, Vol. 57 Issue 9, p1-15. 15p.

A gene dosage‐dependent effect unveils NBS1 as both a haploinsufficient tumour suppressor and an essential gene for SHH‐medulloblastoma.

Autor: Petroni, Marialaura^1,2 (AUTHOR), Fabretti, Francesca¹ (AUTHOR), Di Giulio, Stefano¹ (AUTHOR), Nicolis di Robilant, Vittoria¹ (AUTHOR), La Monica, Veronica¹ (AUTHOR), Moretti, Marta³ (AUTHOR), Belardinilli, Francesca¹ (AUTHOR), Bufalieri, Francesca¹ (AUTHOR), Coppa, Anna³ (AUTHOR), Paci, Paola^4,5 (AUTHOR), Corsi, Alessandro¹ (AUTHOR), De Smaele, Enrico³ (AUTHOR), Coni, Sonia¹ (AUTHOR), Canettieri, Gianluca^1,2 (AUTHOR), Di Marcotullio, Lucia¹ (AUTHOR), Wang, Zhao‐Qi⁶ (AUTHOR), Giannini, Giuseppe^1,2 (AUTHOR) giuseppe.giannini@uniroma1.it

Publikováno v: Neuropathology & Applied Neurobiology. Oct2022, Vol. 48 Issue 6, p1-13. 13p.

RAG1/2 induces double‐stranded DNA breaks at non‐Ig loci in the proximity of single sequence repeats in developing B cells.

Autor: Ochodnicka‐Mackovicova, Katarina, Mokry, Michal, Haagmans, Martin, Bradley, Ted E., van Noesel, Carel J.M., Guikema, Jeroen E.J.

Publikováno v: European Journal of Immunology; Oct2024, Vol. 54 Issue 10, p1-13, 13p

Germline and somatic alterations in NBN and their putative impact on the pathogenesis of malignant neoplasms

Autor: O. M. Krivtsova, D. D. Ozerova, N. L. Lazarevich

Publikováno v: Успехи молекулярной онкологии, Vol 11, Iss 3, Pp 8-23 (2024)

Disruption of mechanisms that maintain genome stability is an essential factor of tumor progression. Accordingly, predisposition to the development of neoplasms is often associated with germline mutations in genes involved in DNA damage detection and

Externí odkaz: https://doaj.org/article/5e40f409f8c042eaabb4eac49d3d4a98

NBS1 lactylation and damaged DNA repair.

Autor: Koeffler, H Phillip¹ (AUTHOR) koeffler3@gmail.com

Publikováno v: Cancer Letters. Nov2024, Vol. 604, pN.PAG-N.PAG. 1p.